Prof. Dr. rer. nat. Mladen Tzvetkov

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  • 2022 | Journal Article | 
    ​ ​Effects of HSD11B1 knockout and overexpression on local cortisol production and differentiation of mesenchymal stem cells​
    Kragl, A.; Schoon, J.; Tzvetkova, A.; Wenzel, C.; Blaschke, M.; Böcker, W. & Siggelkow, H.  et al.​ (2022) 
    Frontiers in Bioengineering and Biotechnology, 10 art. 953034​.​ DOI: https://doi.org/10.3389/fbioe.2022.953034 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Oral Yohimbine as a New Probe Drug to Predict CYP2D6 Activity: Results of a Fixed-Sequence Phase I Trial​
    Vay, M.; Meyer, M. J. ; Blank, A.; Skopp, G.; Rose, P.; Tzvetkov, M. V.   & Mikus, G.​ (2020) 
    Clinical Pharmacokinetics, 59(7) pp. 927​-939​.​ DOI: https://doi.org/10.1007/s40262-020-00862-6 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​TIM-3 Genetic Variants Are Associated with Altered Clinical Outcome and Susceptibility to Gram-Positive Infections in Patients with Sepsis​
    Mewes, C.; Alexander, T.; Büttner, B. ; Hinz, J. ; Alpert, A.; Popov, A.-F. & Ghadimi, M.  et al.​ (2020) 
    International Journal of Molecular Sciences, 21(21) pp. 8318​.​ DOI: https://doi.org/10.3390/ijms21218318 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​A double-Flp-in method for stable overexpression of two genes​
    Jensen, O. ; Ansari, S.; Gebauer, L.; Müller, S. F.; Lowjaga, K. A. A. T.; Geyer, J. & Tzvetkov, M. V.  et al.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-71051-5 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans​
    Matthaei, J. ; Bonat, W. H.; Kerb, R.; Tzvetkov, M. V. ; Strube, J.; Brunke, S. & Sachse-Seeboth, C. et al.​ (2020) 
    Frontiers in Genetics, 11.​ DOI: https://doi.org/10.3389/fgene.2020.00944 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper
    ​ ​Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters​
    Jensen, O. ; Rafehi, M. ; Tzvetkov, M. V.   & Brockmöller, J. ​ (2020) 
    Biochemical Pharmacology, 171 pp. 113731​.​ DOI: https://doi.org/10.1016/j.bcp.2019.113731 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1​
    Meyer, M. J. ; Neumann, V. E.; Friesacher, H. R.; Zdrazil, B.; Brockmöller, J.   & Tzvetkov, M. V. ​ (2019) 
    Journal of Medicinal Chemistry, 62(21) pp. 9890​-9905​.​ DOI: https://doi.org/10.1021/acs.jmedchem.9b01301 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families​
    CHEN, J.-Y.; Brockmöller, J. ; Tzvetkov, M. V. ; Wang, L.-J. & Chen, X.-J.​ (2019) 
    Chinese Journal of Natural Medicines, 17(7) pp. 490​-497​.​ DOI: https://doi.org/10.1016/S1875-5364(19)30070-6 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil​
    Matthaei, J. ; Seitz, T. ; Jensen, O. ; Tann, A.; Prukop, T. ; Tadjerpisheh, S. & Brockmöller, J.  et al.​ (2019) 
    Clinical Pharmacology and Therapeutics, 105(1) pp. 190​-200​.​ DOI: https://doi.org/10.1002/cpt.1128 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​Variability and heritability of thiamine pharmacokinetics with focus on OCT1 effects on membrane transport and pharmacokinetics in humans​
    Jensen, O. ; Matthaei, J. ; Blome, F.; Schwab, M.; Tzvetkov, M. V.   & Brockmöller, J. ​ (2019) 
    Clinical Pharmacology and Therapeutics, 107(3) pp. 628​-638​.​ DOI: https://doi.org/10.1002/cpt.1666 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients-A Monocentric Prospective Genetic Association Study​
    Runzheimer, J.; Mewes, C.; Büttner, B. ; Hinz, J. M. ; Popov, A.-F.; Ghadimi, M. B.   & Kristof, K. et al.​ (2019) 
    Journal of Clinical Medicine, 8(3) art. 301​.​ DOI: https://doi.org/10.3390/jcm8030301 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​CTLA-4 Genetic Variants Predict Survival in Patients with Sepsis​
    Mewes, C.; Büttner, B. ; Hinz, J. M. ; Alpert, A.; Popov, A.-F.; Ghadimi, M. B.   & Beißbarth, T.  et al.​ (2019) 
    Journal of Clinical Medicine, 8(1) art. 70​.​ DOI: https://doi.org/10.3390/jcm8010070 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A​
    Rafehi, M. ; Faltraco, F.; Matthaei, J. ; Prukop, T. ; Jensen, O. ; Grytzmann, A. & Berger, R. G. et al.​ (2019) 
    Frontiers in Pharmacology, 10 pp. 1297​.​ DOI: https://doi.org/10.3389/fphar.2019.01297 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake​
    Gorboulev, V.; Rehman, S.; Albert, C. M.; Roth, U.; Meyer, M. J. ; Tzvetkov, M. V.   & Mueller, T. D. et al.​ (2018) 
    Molecular Pharmacology, 93(4) pp. 402​-415​.​ DOI: https://doi.org/10.1124/mol.117.110767 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1)​
    Bokelmann, K.; Brockmöller, J.   & Tzvetkov, M. ​ (2018) 
    Journal of Personalized Medicine, 8(4) pp. 42​.​ DOI: https://doi.org/10.3390/jpm8040042 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​The CTLA-4 rs231775 GG genotype is associated with favorable 90-day survival in Caucasian patients with sepsis​
    Mewes, C.; Büttner, B. ; Hinz, J. M. ; Alpert, A.; Popov, A.-F.; Ghadimi, M. B.   & Beißbarth, T.  et al.​ (2018) 
    Scientific Reports, 8(1).​ DOI: https://doi.org/10.1038/s41598-018-33246-9 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | 
    ​ ​The FER rs4957796 TT genotype is associated with unfavorable 90-day survival in Caucasian patients with severe ARDS due to pneumonia.​
    Hinz, J. M. ; Büttner, B. ; Kriesel, F.; Steinau, M.; Popov, A.-F.; Ghadimi, M. B.   & Beißbarth, T.  et al.​ (2017) 
    Scientific reports, 7(1) art. 9887​.​ DOI: https://doi.org/10.1038/s41598-017-08540-7 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​OCT1 pharmacogenetics in pain management: is a clinical application within reach?​
    Tzvetkov, M. V ​ (2017) 
    Pharmacogenomics, 18(16) pp. 1515​-1523​.​ DOI: https://doi.org/10.2217/pgs-2017-0095 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency​
    Tzvetkov, M. V. ; Matthaei, J. ; Pojar, S.; Faltraco, F.; Vogler, S.; Prukop, T.   & Seitz, T.  et al.​ (2017) 
    Clinical Pharmacology & Therapeutics, 103(5) pp. 868​-878​.​ DOI: https://doi.org/10.1002/cpt.812 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine​
    Meyer, M. J. ; Seitz, T. ; Brockmöller, J.   & Tzvetkov, M. V. ​ (2017) 
    PLOS ONE, 12(12) art. e0189521​.​ DOI: https://doi.org/10.1371/journal.pone.0189521 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2​
    Matthaei, J.; Tzvetkov, M. V. ; Strube, J.; Sehrt, D.; Sachse-Seeboth, C.; Hjelmborg, J. B. & Möller, S. et al.​ (2016) 
    Clinical Pharmacology & Therapeutics, 100(6) pp. 606​-616​.​ DOI: https://doi.org/10.1002/cpt.444 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Genetic Polymorphisms in Endothelin-1 as Predictors for Long-Term Survival and the Cardiac Index in Patients Undergoing On-Pump Cardiac Surgery​
    Mansur, A. ; Steinau, M.; Popov, A.-F.; Milenovic, S.; Bireta, C. ; Weymann, A. & Schotola, H. et al.​ (2015) 
    PLoS ONE, 10(6) art. e0131155​.​ DOI: https://doi.org/10.1371/journal.pone.0131155 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma​
    Reichwagen, A.; Ziepert, M.; Kreuz, M.; Gödtel-Armbrust, U.; Rixecker, T.; Poeschel, V. & Toliat, M. R. et al.​ (2015) 
    Pharmacogenomics, 16(4) pp. 361​-372​.​ DOI: https://doi.org/10.2217/PGS.14.179 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​The CD14 rs2569190 TT Genotype Is Associated with an Improved 30-Day Survival in Patients with Sepsis: A Prospective Observational Cohort Study​
    Mansur, A. ; Liese, B.; Steinau, M.; Ghadimi, M. B. ; Bergmann, I. ; Tzvetkov, M. V.   & Popov, A.-F. et al.​ (2015) 
    PLoS ONE, 10(5) art. e0127761​.​ DOI: https://doi.org/10.1371/journal.pone.0127761 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​Heritability of Metoprolol and Torsemide Pharmacokinetics​
    Matthaei, J. ; Brockmöller, J. ; Tzvetkov, M. V. ; Sehrt, D.; Sachse-Seeboth, C.; Hjelmborg, J. B. & Möller, S. et al.​ (2015) 
    Clinical Pharmacology & Therapeutics, 98(6) pp. 611​-621​.​ DOI: https://doi.org/10.1002/cpt.258 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article
    ​ ​Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines​
    Kuehne, A.; Tzvetkov, M. V. ; Hagos, Y.; Lage, H.; Burckhardt, G. & Brockmoeller, J.​ (2009) 
    Biochemical Pharmacology, 78(1) pp. 45​-53​.​ DOI: https://doi.org/10.1016/j.bcp.2009.03.026 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity​
    Wojnowski, L.; Kulle, B.; Schirmer, M. ; Schlüter, G.; Schmidt, A.; Rosenberger, A.   & Vonhof, S. et al.​ (2005) 
    Circulation, 112(24) pp. 3754​-3762​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.576850 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​Application of genomewide SNP arrays for detection of simulated susceptibility loci​
    Kulle, B.; Schirmer, M. ; Toliat, M. R.; Suk, A.; Becker, C.; Tzvetkov, M.   & Brockmöller, J.  et al.​ (2005) 
    Human Mutation, 25(6) pp. 557​-565​.​ DOI: https://doi.org/10.1002/humu.20174 
    ​Details  DOI  PMID  PMC  WoS 

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