Dr. rer. nat. Muhammad Rafehi

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  • 2021 | Journal Article | Research Paper | 
    ​ ​Cellular Uptake of Psychostimulants – Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?​
    Jensen, O. ; Rafehi, M. ; Gebauer, L. & Brockmöller, J. ​ (2021) 
    Frontiers in Pharmacology, 11.​ DOI: https://doi.org/10.3389/fphar.2020.609811 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients​
    Steimer, W.; Pischa, K.; Leucht, S.; Kullmann, M.; Ouethy, T.; Rafehi, M.   & Matthaei, J. et al.​ (2021) 
    Frontiers in Pharmacology, 12.​ DOI: https://doi.org/10.3389/fphar.2021.688950 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper
    ​ ​Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors​
    Voss, J. H.; Nagel, J.; Rafehi, M. ; Guixà-González, R.; Malfacini, D.; Patt, J. & Kehraus, S. et al.​ (2021) 
    Pharmacological Research, 173 pp. 105880​.​ DOI: https://doi.org/10.1016/j.phrs.2021.105880 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Ligand binding and activation of UTP-activated G protein-coupled P2Y2 and P2Y4 receptors elucidated by mutagenesis, pharmacological and computational studies​
    Attah, I. Y; Neumann, A.; Al-Hroub, H.; Rafehi, M. ; Baqi, Y.; Namasivayam, V. & Müller, C. E​ (2020) 
    Biochimica et Biophysica Acta. General Subjects, 1864(3) pp. 129501​.​ DOI: https://doi.org/10.1016/j.bbagen.2019.129501 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Cell‐permeable high‐affinity tracers for G q proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors​
    Kuschak, M.; Namasivayam, V.; Rafehi, M. ; Voss, J. H.; Garg, J.; Schlegel, J. G. & Abdelrahman, A. et al.​ (2020) 
    British Journal of Pharmacology, 177(8) pp. 1898​-1916​.​ DOI: https://doi.org/10.1111/bph.14960 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters​
    Jensen, O. ; Rafehi, M. ; Tzvetkov, M. V.   & Brockmöller, J. ​ (2020) 
    Biochemical Pharmacology, 171 pp. 113731​.​ DOI: https://doi.org/10.1016/j.bcp.2019.113731 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Adenine-(methoxy)-ethoxy-Pα,α-dithio-triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes​
    Nassir, M.; Mirza, S.; Arad, U.; Lee, S.; Rafehi, M. ; Yaw Attah, I. & Renn, C. et al.​ (2019) 
    Organic & Biomolecular Chemistry, 17(46) pp. 9913​-9923​.​ DOI: https://doi.org/10.1039/C9OB02199J 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A​
    Rafehi, M. ; Faltraco, F.; Matthaei, J. ; Prukop, T. ; Jensen, O. ; Grytzmann, A. & Berger, R. G. et al.​ (2019) 
    Frontiers in Pharmacology, 10 pp. 1297​.​ DOI: https://doi.org/10.3389/fphar.2019.01297 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors​
    Hinz, S.; Navarro, G.; Borroto-Escuela, D.; Seibt, B. F; Ammon, Y.-C.; de Filippo, E. & Danish, A. et al.​ (2018) 
    Oncotarget, 9(17) pp. 13593​-13611​.​ DOI: https://doi.org/10.18632/oncotarget.24423 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Tools and drugs for uracil nucleotide-activated P2Y receptors​
    Rafehi, M.   & Müller, C. E​ (2018) 
    Pharmacology & Therapeutics, 190 pp. 24​-80​.​ DOI: https://doi.org/10.1016/j.pharmthera.2018.04.002 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17​
    Baqi, Y.; Pillaiyar, T.; Abdelrahman, A.; Kaufmann, O.; Alshaibani, S.; Rafehi, M.   & Ghasimi, S. et al.​ (2018) 
    Journal of Medicinal Chemistry, 61(18) pp. 8136​-8154​.​ DOI: https://doi.org/10.1021/acs.jmedchem.7b01768 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Development of Potent and Selective Antagonists for the UTP-Activated P2Y4 Receptor​
    Rafehi, M. ; Malik, E. M; Neumann, A.; Abdelrahman, A.; Hanck, T.; Namasivayam, V. & Müller, C. E et al.​ (2017) 
    Journal of Medicinal Chemistry, 60(7) pp. 3020-3038​-3038​.​ DOI: https://doi.org/10.1021/acs.jmedchem.7b00030 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925​
    Rafehi, M. ; Burbiel, J. C; Attah, I. Y; Abdelrahman, A. & Müller, C. E​ (2017) 
    Purinergic Signalling, 13(1) pp. 89-103​-103​.​ DOI: https://doi.org/10.1007/s11302-016-9542-3 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y2 Receptor​
    Rafehi, M. ; Neumann, A.; Baqi, Y.; Malik, E. M; Wiese, M.; Namasivayam, V. & Müller, C. E​ (2017) 
    Journal of Medicinal Chemistry, 60(20) pp. 8425​-8440​.​ DOI: https://doi.org/10.1021/acs.jmedchem.7b00854 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper
    ​ ​8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors​
    Brunschweiger, A.; Koch, P.; Schlenk, M.; Rafehi, M. ; Radjainia, H.; Küppers, P. & Hinz, S. et al.​ (2016) 
    Bioorganic & Medicinal Chemistry, 24(21) pp. 5462-5480​-5480​.​ DOI: https://doi.org/10.1016/j.bmc.2016.09.003 
    ​Details  DOI  PMID  PMC 

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