Prof. Dr. Tim Friede

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  • 2023 | Journal Article | Research Paper
    ​ ​Development of an interprofessional person-centred care concept for persons with care needs living in their own homes ( interprof HOME): study protocol for a mixed-methods study​
    Tetzlaff, B.; Scherer, M.; Balzer, K.; Steyer, L.; Köpke, S.; Friede, T.   & Maurer, I. et al.​ (2023) 
    BMJ Open, 13(7) art. e069597​.​ DOI: https://doi.org/10.1136/bmjopen-2022-069597 
    ​Details  DOI 
  • 2023 | Journal Article | Research Paper | 
    ​ ​Evaluating an app for digital medical history taking in urgent care practices: study protocol of the cluster-randomized interventional trial ‘DASI’​
    Noack, E. M. ; Zajontz, D.; Friede, T. ; Antweiler, K.; Hummers, E. ; Schmidt, T. & Roddewig, L. et al.​ (2023) 
    BMC Primary Care, 24(1) art. 108​.​ DOI: https://doi.org/10.1186/s12875-023-02065-x 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | 
    ​ ​Using the bayesmeta R package for Bayesian random-effects meta-regression​
    Röver, C.   & Friede, T. ​ (2023) 
    Computer Methods and Programs in Biomedicine, 229 art. 107303​.​ DOI: https://doi.org/10.1016/j.cmpb.2022.107303 
    ​Details  DOI  PMID  PMC  arXiv 
  • 2023 | Journal Article
    ​ ​Cost-Effectiveness of Inter-Professional Collaboration to Reduce Hospitalisations in Nursing Home Residents: Results from the German Interprof ACT Trial​
    Muntendorf, L.-K.; Balzer, K.; Friede, T. ; Hummers, E. ; König, H.-H.; Müller, C. A.   & Scherer, M. et al.​ (2023) 
    International Journal of Integrated Care, 23(2) pp. 8​.​ DOI: https://doi.org/10.5334/ijic.7001 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | Research Paper | 
    ​ ​Cluster randomised trial of a complex interprofessional intervention (interprofACT) to reduce hospital admission of nursing home residents​
    Mazur, A. ; Tetzlaff, B.; Mallon, T.; Hesjedal-Streller, B.; Weiß, V.; Scherer, M. & Köpke, S. et al.​ (2023) 
    Age and Ageing, 52(3).​ DOI: https://doi.org/10.1093/ageing/afad022 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​A straightforward meta-analysis approach for oncology phase I dose-finding studies​
    Röver, C. ; Ursino, M.; Zohar, S. & Friede, T. ​ (2022) 
    Statistics in Medicine, 41(20) art. sim.9484​.​ DOI: https://doi.org/10.1002/sim.9484 
    ​Details  DOI  PMID  PMC  arXiv 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Implementation, mechanisms of change and contextual factors of a complex intervention to improve interprofessional collaboration and the quality of medical care for nursing home residents: study protocol of the process evaluation of the interprof ACT intervention package​
    Steyer, L.; Kortkamp, C.; Müller, C. ; Tetzlaff, B.; Fleischmann, N. ; Weber, C. E. & Scherer, M. et al.​ (2022) 
    Trials, 23(1) art. 561​.​ DOI: https://doi.org/10.1186/s13063-022-06476-6 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Immunotherapy for people with clinically isolated syndrome or relapsing-remitting multiple sclerosis: treatment response by demographic, clinical, and biomarker subgroups (PROMISE)—a systematic review protocol​
    Lehnert, T.; Köpke, S.; Rio, J.; Chard, D.; Fittipaldo, A. V.; Heesen, C. & Rahn, A. C. et al.​ (2022) 
    Systematic Reviews, 11(1) art. 134​.​ DOI: https://doi.org/10.1186/s13643-022-01997-2 
    ​Details  DOI 
  • 2022 | Preprint
    ​ ​MetaStan: An R package for Bayesian (model-based) meta-analysis using Stan​
    Kürsad Günhan, B.; Röver, C.  & Friede, T. ​ (2022)
    ​Details 
  • 2022 | Journal Article
    ​ ​Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial​
    Butler, J.; Anker, S. D. ; Lund, L. H.; Coats, A. J. S.; Filippatos, G.; Siddiqi, T. J. & Friede, T.  et al.​ (2022) 
    European Heart Journal, art. ehac401​.​ DOI: https://doi.org/10.1093/eurheartj/ehac401 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Development and Validation of a Predictive Model for Toxicity of Neoadjuvant Chemoradiotherapy in Rectal Cancer in the CAO/ARO/AIO-04 Phase III Trial​
    Diefenhardt, M.; Martin, D.; Ludmir, E. B.; Fleischmann, M.; Hofheinz, R.-D.; Ghadimi, M.   & Kosmala, R. et al.​ (2022) 
    Cancers, 14(18) pp. 4425​.​ DOI: https://doi.org/10.3390/cancers14184425 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Improving the statistical power of economic experiments using adaptive designs​
    Jobjörnsson, S.; Schaak, H.; Musshoff, O.   & Friede, T. ​ (2022) 
    Experimental Economics,.​ DOI: https://doi.org/10.1007/s10683-022-09773-8 
    ​Details  DOI 
  • 2021 | Lecture
    ​ ​Statistik in der klinischen Forschung​
    Friede, T. ​ (2021)
    Künstliche Intelligenz, Data Science und Gesellschaft; 2021-12-21​, Göttingen.
    ​Details 
  • 2021 | Journal Article | Research Paper
    ​ ​Herbal treatment with uva ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: a randomized controlled trial​
    Gágyor, I. ; Hummers, E. ; Schmiemann, G.; Friede, T. ; Pfeiffer, S.; Afshar, K. & Bleidorn, J.​ (2021) 
    Clinical Microbiology and Infection, 27(10) pp. 1441​-1447​.​ DOI: https://doi.org/10.1016/j.cmi.2021.05.032 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​Exercise-Stress Real-time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The HFpEF Stress Trial​
    Backhaus, S. J; Lange, T.; George, E. F; Hellenkamp, K. ; Gertz, R. J; Billing, M. & Wachter, R.  et al.​ (2021) 
    Circulation,.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.120.051542 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article
    ​ ​A potential for seamless designs in diagnostic research could be identified​
    Vach, W.; Bibiza, E.; Gerke, O.; Bossuyt, P. M.; Friede, T.   & Zapf, A. ​ (2021) 
    Journal of Clinical Epidemiology, 129 pp. 51​-59​.​ DOI: https://doi.org/10.1016/j.jclinepi.2020.09.019 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Functional outcomes with Carillon device over 1 year in patients with functional mitral regurgitation of Grades 2+ to 4+: results from the REDUCE‐FMR trial​
    Khan, M. S.; Siddiqi, T. J.; Butler, J.; Friede, T. ; Levy, W. C.; Witte, K. K. & Lipiecki, J. et al.​ (2021) 
    ESC Heart Failure, 8(2) pp. 872​-878​.​ DOI: https://doi.org/10.1002/ehf2.13273 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Study protocol for a randomised controlled trial of a web-based behavioural lifestyle programme for emPOWERment in early Multiple Sclerosis (POWER@MS1)​
    Krause, N.; Riemann-Lorenz, K.; Steffen, T.; Rahn, A. C.; Pöttgen, J.; Stellmann, J.-P. & Köpke, S. et al.​ (2021) 
    BMJ Open, 11(2) pp. e041720​.​ DOI: https://doi.org/10.1136/bmjopen-2020-041720 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​A confidence interval robust to publication bias for random‐effects meta‐analysis of few studies​
    Henmi, M.; Hattori, S. & Friede, T. ​ (2021) 
    Research Synthesis Methods,.​ DOI: https://doi.org/10.1002/jrsm.1482 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Bounds for the weight of external data in shrinkage estimation​
    Röver, C.   & Friede, T. ​ (2021) 
    Biometrical Journal, 63(5) pp. 1131​-1143​.​ DOI: https://doi.org/10.1002/bimj.202000227 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Chances and challenges of a long-term data repository in multiple sclerosis: 20th birthday of the German MS registry​
    Ohle, L.-M.; Ellenberger, D. ; Flachenecker, P.; Friede, T. ; Haas, J.; Hellwig, K. & Parciak, T. et al.​ (2021) 
    Scientific Reports, 11(1) art. 13340​.​ DOI: https://doi.org/10.1038/s41598-021-92722-x 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​On weakly informative prior distributions for the heterogeneity parameter in Bayesian random‐effects meta‐analysis​
    Röver, C. ; Bender, R.; Dias, S.; Schmid, C. H.; Schmidli, H.; Sturtz, S. & Weber, S. et al.​ (2021) 
    Research Synthesis Methods,.​ DOI: https://doi.org/10.1002/jrsm.1475 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Acute respiratory infections in an adult refugee population: an observational study​
    Jablonka, A.; Dopfer, C.; Happle, C.; Shalabi, A.; Wetzke, M.; Hummers, E.   & Friede, T.  et al.​ (2021) 
    npj Primary Care Respiratory Medicine, 31(1).​ DOI: https://doi.org/10.1038/s41533-021-00261-9 
    ​Details  DOI 
  • 2020 | Lecture
    ​ ​Klinische Forschung in Zeiten von Corona​
    Friede, T. ​ (2020)
    Ein Virus verändert die Welt: Göttinger Wissenschaftler*innen zur Corona-Pandemie; 2020-05-05​, virtuell.
    ​Details 
  • 2020 | Journal Article
    ​ ​Shrinkage Estimation for Dose–Response Modeling in Phase II Trials With Multiple Schedules​
    Günhan, B. K. ; Meyvisch, P. & Friede, T. ​ (2020) 
    Statistics in Biopharmaceutical Research, pp. 1​-13​.​ DOI: https://doi.org/10.1080/19466315.2020.1850519 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Data monitoring committees for clinical trials evaluating treatments of COVID-19​
    Mütze, T.   & Friede, T. ​ (2020) 
    Contemporary Clinical Trials, 98 pp. 106154​.​ DOI: https://doi.org/10.1016/j.cct.2020.106154 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Self-diagnosed COVID-19 in people with multiple sclerosis: a community-based cohort of the UK MS Register​
    Evangelou, N.; Garjani, A.; dasNair, R.; Hunter, R.; Tuite-Dalton, K. A; Craig, E. M & Rodgers, W. J et al.​ (2020) 
    Journal of Neurology, Neurosurgery & Psychiatry, 92(1) pp. 107​-109​.​ DOI: https://doi.org/10.1136/jnnp-2020-324449 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Adaptive seamless clinical trials using early outcomes for treatment or subgroup selection: Methods, simulation model and their implementation in R​
    Friede, T. ; Stallard, N. & Parsons, N.​ (2020) 
    Biometrical Journal, 62(5) pp. 1264​-1283​.​ DOI: https://doi.org/10.1002/bimj.201900020 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Efficacy and safety of SGLT2 inhibitors in heart failure: systematic review and meta‐analysis​
    Butler, J.; Usman, M. S.; Khan, M. S.; Greene, S. J.; Friede, T. ; Vaduganathan, M. & Filippatos, G. et al.​ (2020) 
    ESC Heart Failure, 7(6) pp. 3298​-3309​.​ DOI: https://doi.org/10.1002/ehf2.13169 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Predicting menstrual bleeding patterns with levonorgestrel-releasing intrauterine systems​
    Frenz, A.-K.; Ahlers, C.; Beckert, V.; Gerlinger, C. & Friede, T. ​ (2020) 
    The European Journal of Contraception & Reproductive Health Care, 26(1) pp. 48​-57​.​ DOI: https://doi.org/10.1080/13625187.2020.1843015 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Simvastatin add-on to escitalopram in patients with comorbid obesity and major depression (SIMCODE): study protocol of a multicentre, randomised, double-blind, placebo-controlled trial​
    Otte, C.; Chae, W. R.; Nowacki, J.; Kaczmarczyk, M.; Piber, D.; Roepke, S. & Märschenz, S. et al.​ (2020) 
    BMJ Open, 10(12) pp. e040119​.​ DOI: https://doi.org/10.1136/bmjopen-2020-040119 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Application of the Reverse Fragility Index to Statistically Nonsignificant Randomized Clinical Trial Results​
    Khan, M. S.; Fonarow, G. C.; Friede, T. ; Lateef, N.; Khan, S. U.; Anker, S. D.   & Harrell, F. E. et al.​ (2020) 
    JAMA Network Open, 3(8) pp. e2012469​.​ DOI: https://doi.org/10.1001/jamanetworkopen.2020.12469 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Reporting and interpretation of subgroup analyses in heart failure randomized controlled trials​
    Khan, M. S.; Khan, M. A. A.; Irfan, S.; Siddiqi, T. J.; Greene, S. J.; Anker, S. D.   & Sreenivasan, J. et al.​ (2020) 
    ESC Heart Failure, 8(1) pp. 26​-36​.​ DOI: https://doi.org/10.1002/ehf2.13122 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Longitudinal Assessment of Multiple Sclerosis with the Brain‐Age Paradigm​
    Cole, J. H.; Raffel, J.; Friede, T. ; Eshaghi, A.; Brownlee, W. J.; Chard, D. & De Stefano, N. et al.​ (2020) 
    Annals of Neurology, 88(1) pp. 93​-105​.​ DOI: https://doi.org/10.1002/ana.25746 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Multiple Sklerose in Deutschland: aktualisierte Auswertungen des MS-Registers der DMSG 2014–2018​
    Flachenecker, P.; Eichstädt, K.; Berger, K.; Ellenberger, D. ; Friede, T. ; Haas, J. & Kleinschnitz, C. et al.​ (2020) 
    Fortschritte der Neurologie · Psychiatrie, 88(07) pp. 436​-450​.​ DOI: https://doi.org/10.1055/a-0985-4124 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Sporadic Creutzfeldt-Jakob Disease among Physicians, Germany, 1993–2018​
    Hermann, P. ; Treig, J.; Unkel, S. ; Goebel, S. ; Bunck, T. ; Jünemann, M. & Friede, T.  et al.​ (2020) 
    Emerging Infectious Diseases, 26(8).​ DOI: https://doi.org/10.3201/eid2608.191159 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Causal inference methods for small non-randomized studies: Methods and an application in COVID-19​
    Friedrich, S.   & Friede, T. ​ (2020) 
    Contemporary Clinical Trials, 99 pp. 106213​.​ DOI: https://doi.org/10.1016/j.cct.2020.106213 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Survival analysis for AdVerse events with VarYing follow‐up times (SAVVY): Rationale and statistical concept of a meta‐analytic study​
    Stegherr, R.; Beyersmann, J.; Jehl, V.; Rufibach, K.; Leverkus, F.; Schmoor, C. & Friede, T. ​ (2020) 
    Biometrical Journal, 63(3) pp. 650​-670​.​ DOI: https://doi.org/10.1002/bimj.201900347 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Clinical Trials Impacted by the COVID-19 Pandemic: Adaptive Designs to the Rescue?​
    Kunz, C. U.; Jörgens, S.; Bretz, F.; Stallard, N.; Van Lancker, K.; Xi, D. & Zohar, S. et al.​ (2020) 
    Statistics in Biopharmaceutical Research, 12(4) pp. 461​-477​.​ DOI: https://doi.org/10.1080/19466315.2020.1799857 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Efficient Adaptive Designs for Clinical Trials of Interventions for COVID-19​
    Stallard, N.; Hampson, L.; Benda, N.; Brannath, W.; Burnett, T.; Friede, T.   & Kimani, P. K. et al.​ (2020) 
    Statistics in Biopharmaceutical Research, 12(4) pp. 483​-497​.​ DOI: https://doi.org/10.1080/19466315.2020.1790415 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Exact change point detection with improved power in small‐sample binomial sequences​
    Ellenberger, D. ; Lausen, B. & Friede, T. ​ (2020) 
    Biometrical Journal, 63(3) pp. 558​-574​.​ DOI: https://doi.org/10.1002/bimj.201900273 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Role of the proportion of sudden cardiac death to mortality for clinical effectiveness of primary prevention ICDs​
    Zabel, M. ; Friede, T. ; Huikuri, H.; Malik, M. & Willems, R.​ (2020) 
    European Heart Journal, 41(47) pp. 4527​-4528​.​ DOI: https://doi.org/10.1093/eurheartj/ehaa630 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: an Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)​
    Anker, S. D ; Butler, J.; Khan, M. S.; Abraham, W. T; Bauersachs, J. ; Bocchi, E. & Bozkurt, B. et al.​ (2020) 
    European Heart Journal, 41(22) pp. 2109​-2117​.​ DOI: https://doi.org/10.1093/eurheartj/ehaa461 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Long-term effects of a standardized feedback-driven quality improvement program for timely reperfusion therapy in regional STEMI care networks​
    Scholz, K. H.; Lengenfelder, B.; Jacobshagen, C. ; Fleischmann, C.; Moehlis, H.; Olbrich, H. G & Jung, J. et al.​ (2020) 
    European Heart Journal. Acute Cardiovascular Care,.​ DOI: https://doi.org/10.1177/2048872620907323 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Blinded continuous information monitoring of recurrent event endpoints with time trends in clinical trials​
    Mütze, T. ; Salem, S.; Benda, N.; Schmidli, H. & Friede, T. ​ (2020) 
    Statistics in Medicine, 39(27) pp. 3968​-3985​.​ DOI: https://doi.org/10.1002/sim.8702 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​A systematic review and meta‐analysis of published cases reveals the natural disease history in multiple sulfatase deficiency​
    Schlotawa, L.; Preiskorn, J.; Ahrens‐Nicklas, R.; Schiller, S. ; Adang, L. A.; Gärtner, J.   & Friede, T. ​ (2020) 
    Journal of Inherited Metabolic Disease, 43(6) pp. 1288​-1297​.​ DOI: https://doi.org/10.1002/jimd.12282 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Sample size recalculation in multicenter randomized controlled clinical trials based on noncomparative data​
    Harden, M.   & Friede, T. ​ (2020) 
    Biometrical Journal, 62(5) pp. 1284​-1299​.​ DOI: https://doi.org/10.1002/bimj.201900138 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Strategies to reduce antibiotic use in women with uncomplicated urinary tract infection in primary care: protocol of a systematic review and meta-analysis including individual patient data​
    Heinz, J. ; Röver, C. ; Furaijat, G.; Kaußner, Y.; Hummers, E. ; Debray, T. & Hay, A. D et al.​ (2020) 
    BMJ Open, 10(10) pp. e035883​.​ DOI: https://doi.org/10.1136/bmjopen-2019-035883 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Blinded sample size reestimation for negative binomial regression with baseline adjustment​
    Zapf, A. ; Asendorf, T. ; Anten, C.; Mütze, T.   & Friede, T. ​ (2020) 
    Statistics in Medicine, 39(14) pp. 1980​-1998​.​ DOI: https://doi.org/10.1002/sim.8525 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Impact of COVID-19 outbreak on regional STEMI care in Germany​
    Scholz, K. H.; Lengenfelder, B.; Thilo, C.; Jeron, A.; Stefanow, S.; Janssens, U. & Bauersachs, J.  et al.​ (2020) 
    Clinical Research in Cardiology, 109(12) pp. 1511​-1521​.​ DOI: https://doi.org/10.1007/s00392-020-01703-z 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​A Bayesian time‐to‐event pharmacokinetic model for phase I dose‐escalation trials with multiple schedules​
    Günhan, B. K. ; Weber, S. & Friede, T. ​ (2020) 
    Statistics in Medicine, 39(27) pp. 3986​-4000​.​ DOI: https://doi.org/10.1002/sim.8703 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Factors Influencing the Frequency of Airway Infections in Underage Refugees: A Retrospective, Cross Sectional Study​
    Müller, F. ; Hummers, E. ; Hillermann, N.; Dopfer, C.; Jablonka, A.; Friede, T.   & Simmenroth, A.  et al.​ (2020) 
    International Journal of Environmental Research and Public Health, 17(18) pp. 6823​.​ DOI: https://doi.org/10.3390/ijerph17186823 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Precise variant interpretation, phenotype ascertainment, and genotype–phenotype correlation of children in the EARLY PRO‐TECT Alport trial​
    Boeckhaus, J.; Hoefele, J.; Riedhammer, K. M.; Tönshoff, B.; Ehren, R.; Pape, L. & Latta, K. et al.​ (2020) 
    Clinical Genetics, 99(1) pp. 143​-156​.​ DOI: https://doi.org/10.1111/cge.13861 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Over three decades study populations in progressive multiple sclerosis have become older and more disabled, but have lower on-trial progression rates: A systematic review and meta-analysis of 43 randomised placebo-controlled trials​
    Nicholas, R. S; Han, E.; Raffel, J.; Chataway, J. & Friede, T. ​ (2019) 
    Multiple Sclerosis Journal, 25(11) pp. 1462​-1471​.​ DOI: https://doi.org/10.1177/1352458518794063 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Group sequential designs for negative binomial outcomes​
    Mütze, T. ; Glimm, E.; Schmidli, H. & Friede, T. ​ (2019) 
    Statistical Methods in Medical Research, 28(8) pp. 2326​-2347​.​ DOI: https://doi.org/10.1177/0962280218773115 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Modelling and sample size reestimation for longitudinal count data with incomplete follow up​
    Asendorf, T. ; Henderson, R.; Schmidli, H. & Friede, T. ​ (2019) 
    Statistical Methods in Medical Research, 28(1) pp. 117​-133​.​ DOI: https://doi.org/10.1177/0962280217715664 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Appropriate Shocks and Mortality in Patients With Versus Without Diabetes With Prophylactic Implantable Cardioverter Defibrillators​
    Junttila, M. J.; Pelli, A.; Kenttä, T. V.; Friede, T. ; Willems, R.; Bergau, L.   & Malik, M. et al.​ (2019) 
    Diabetes Care, 43(1) pp. 196​-200​.​ DOI: https://doi.org/10.2337/dc19-1014 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Improved description of clinical features of multiple sulfatase deficiency: A meta-analysis of published cases​
    Schlotawa, L.; Preiskorn, J.; Ahrens-Nicklas, R.; Adang, L. A.; Gärtner, J.   & Friede, T. ​ (2019) 
    Molecular Genetics and Metabolism, 126(2) pp. S131​.​ DOI: https://doi.org/10.1016/j.ymgme.2018.12.337 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​OC-0501 Chemo-RT plus induction or consolidation chemotherapy for rectal cancer: a randomised phase 2 trial​
    Fokas, E.; Allgäuer, M.; Polat, B.; Klautke, G.; Grabenbauer, G.; Fietkau, R. & Kuhnt, T. et al.​ (2019) 
    Radiotherapy and Oncology, 133 pp. S257​-S258​.​ DOI: https://doi.org/10.1016/S0167-8140(19)30921-1 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Decline of COPD exacerbations in clinical trials over two decades – a systematic review and meta-regression​
    Andreas, S. ; Röver, C. ; Heinz, J. ; Straube, S. ; Watz, H. & Friede, T. ​ (2019) 
    Respiratory Research, 20(1).​ DOI: https://doi.org/10.1186/s12931-019-1163-2 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Present criteria for prophylactic ICD implantation: Insights from the EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope) project​
    Zabel, M. ; Schlögl, S.; Lubinski, A.; Svendsen, J. H.; Bauer, A.; Arbelo, E. & Brusich, S. et al.​ (2019) 
    Journal of Electrocardiology, 57 pp. S34​-S39​.​ DOI: https://doi.org/10.1016/j.jelectrocard.2019.09.001 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Random‐effects meta‐analysis of few studies involving rare events​
    Günhan, B. K. ; Röver, C.   & Friede, T. ​ (2019) 
    Research Synthesis Methods, 11(1) pp. 74​-90​.​ DOI: https://doi.org/10.1002/jrsm.1370 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Dynamically borrowing strength from another study through shrinkage estimation​
    Röver, C.   & Friede, T. ​ (2019) 
    Statistical Methods in Medical Research, 29(1) pp. 293​-308​.​ DOI: https://doi.org/10.1177/0962280219833079 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Exercise training in patients with a left ventricular assist device (Ex‐VAD): rationale and design of a multicentre, prospective, assessor‐blinded, randomized, controlled trial​
    Bobenko, A.; Schoenrath, F.; Knierim, J. H.; Friede, T. ; Verheyen, N.; Mehra, M. R. & Haykowsky, M. et al.​ (2019) 
    European Journal of Heart Failure, 21(9) pp. 1152​-1159​.​ DOI: https://doi.org/10.1002/ejhf.1431 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry “MYKKE”​
    Schubert, S.; Opgen‐Rhein, B.; Boehne, M.; Weigelt, A.; Wagner, R.; Müller, G. & Rentzsch, A. et al.​ (2019) 
    Pediatric Transplantation, 23(7) art. e13548​.​ DOI: https://doi.org/10.1111/petr.13548 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Blinded sample size reestimation in event‐driven clinical trials: Methods and an application in multiple sclerosis​
    Friede, T. ; Pohlmann, H. & Schmidli, H.​ (2019) 
    Pharmaceutical Statistics, 18(3) pp. 351​-365​.​ DOI: https://doi.org/10.1002/pst.1927 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​A conditional error function approach for adaptive enrichment designs with continuous endpoints​
    Placzek, M. & Friede, T. ​ (2019) 
    Statistics in Medicine, 38(17) pp. 3105​-3122​.​ DOI: https://doi.org/10.1002/sim.8154 
    ​Details  DOI 
  • 2018 | Report
    ​ ​KMU-innovativ-13: Validierung eines cfDNA – basierten diagnostischen Tests zur frühzeitigen Erkennung von Transplantatschädigungen bei Nierentransplantationen: ​Teilprojekt 2 : Schlussbericht (Teilprojekt 2) für das Projekt : Projektlaufzeit: 01.02.2015 bis 31.01.2018 (bis 31.03.2018 nach Verlängerung)​
    Oellerich, M.; Beißbarth, T. ; Friede, T. ; Kramer, F. ; Ellenberger, D.  & Asendorf, T. ​ (2018)
    ​Details 
  • 2018 | Journal Article
    ​ ​Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease​
    Gibbons, C.; Pagnini, F.; Friede, T.   & Young, C. A​ (2018) 
    Cochrane Database of Systematic Reviews,.​ DOI: https://doi.org/10.1002/14651858.CD011005.pub2 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Symptomatology and symptomatic treatment in multiple sclerosis: Results from a nationwide MS registry​
    Rommer, P. S.; Eichstädt, K.; Ellenberger, D. ; Flachenecker, P.; Friede, T. ; Haas, J. & Kleinschnitz, C. et al.​ (2018) 
    Multiple Sclerosis Journal, 25(12) pp. 1641​-1652​.​ DOI: https://doi.org/10.1177/1352458518799580 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Decreasing longitudinal use of glucocorticosteroids in multiple sclerosis​
    Ellenberger, D. ; Eichstädt, K.; Flachenecker, P.; Friede, T. ; Haas, J.; Kleinschnitz, C. & Pöhlau, D. et al.​ (2018) 
    Multiple Sclerosis and Related Disorders, 25 pp. 173​-174​.​ DOI: https://doi.org/10.1016/j.msard.2018.07.040 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Baseline predictors for progression 4 years after Parkinson's disease diagnosis in the De Novo Parkinson Cohort (DeNoPa)​
    Mollenhauer, B. ; Zimmermann, J.; Sixel‐Döring, F.; Focke, N. K. ; Wicke, T.; Ebentheuer, J. & Schaumburg, M. et al.​ (2018) 
    Movement Disorders, 34(1) pp. 67​-77​.​ DOI: https://doi.org/10.1002/mds.27492 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial)​
    Stürner, K. H.; Stellmann, J.-P.; Dörr, J.; Paul, F.; Friede, T. ; Schammler, S. & Reinhardt, S. et al.​ (2018) 
    Journal of Neurology, Neurosurgery & Psychiatry, 89(4) pp. 330​-338​.​ DOI: https://doi.org/10.1136/jnnp-2017-317101 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis​
    Pöttgen, J.; Moss-Morris, R.; Wendebourg, J.-M.; Feddersen, L.; Lau, S.; Köpke, S. & Meyer, B. et al.​ (2018) 
    Journal of Neurology, Neurosurgery & Psychiatry, 89(9) pp. 970​-976​.​ DOI: https://doi.org/10.1136/jnnp-2017-317463 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Reclassifying Acute Respiratory Distress Syndrome​
    Maiolo, G.; Collino, F.; Vasques, F.; Rapetti, F.; Tonetti, T. ; Romitti, F.   & Cressoni, M. et al.​ (2018) 
    American Journal of Respiratory and Critical Care Medicine, 197(12) pp. 1586​-1595​.​ DOI: https://doi.org/10.1164/rccm.201709-1804OC 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​dfpk: An R-package for Bayesian dose-finding designs using pharmacokinetics (PK) for phase I clinical trials​
    Toumazi, A.; Comets, E.; Alberti, C.; Friede, T. ; Lentz, F.; Stallard, N. & Zohar, S. et al.​ (2018) 
    Computer Methods and Programs in Biomedicine, 157 pp. 163​-177​.​ DOI: https://doi.org/10.1016/j.cmpb.2018.01.023 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Echocardiographic Estimation of Mean Pulmonary Artery Pressure: A Comparison of Different Approaches to Assign the Likelihood of Pulmonary Hypertension​
    Hellenkamp, K. ; Unsöld, B.; Mushemi-Blake, S.; Shah, A. M.; Friede, T. ; Hasenfuß, G.   & Seidler, T. ​ (2018) 
    Journal of the American Society of Echocardiography, 31(1) pp. 89​-98​.​ DOI: https://doi.org/10.1016/j.echo.2017.09.009 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Group sequential designs with robust semiparametric recurrent event models​
    Mütze, T. ; Glimm, E.; Schmidli, H. & Friede, T. ​ (2018) 
    Statistical Methods in Medical Research, 28(8) pp. 2385​-2403​.​ DOI: https://doi.org/10.1177/0962280218780538 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Methods for evidence synthesis in the case of very few studies​
    Bender, R.; Koch, A.; Kuss, O.; Schlattmann, P.; Schwarzer, G.; Skipka, G. & Friede, T. ​ (2018) 
    Research Synthesis Methods, 9(3) pp. 382​-392​.​ DOI: https://doi.org/10.1002/jrsm.1297 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Blinded continuous monitoring in clinical trials with recurrent event endpoints​
    Friede, T. ; Häring, D. A. & Schmidli, H.​ (2018) 
    Pharmaceutical Statistics, 18(1) pp. 54​-64​.​ DOI: https://doi.org/10.1002/pst.1907 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Sample size re‐estimation for clinical trials with longitudinal negative binomial counts including time trends​
    Asendorf, T. ; Henderson, R.; Schmidli, H. & Friede, T. ​ (2018) 
    Statistics in Medicine, 38(9) pp. 1503​-1528​.​ DOI: https://doi.org/10.1002/sim.8061 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Recent advances in methodology for clinical trials in small populations: the InSPiRe project.​
    Friede, T. ; Posch, M.; Zohar, S.; Alberti, C.; Benda, N.; Comets, E. & Day, S. et al.​ (2018) 
    Orphanet Journal of Rare Diseases, 13 art. 186​.​ DOI: https://doi.org/10.1186/s13023-018-0919-y 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Robustness of testing procedures for confirmatory subpopulation analyses based on a continuous biomarker​
    Graf, A. C.; Wassmer, G.; Friede, T. ; Gera, R. G.   & Posch, M.​ (2018) 
    Statistical Methods in Medical Research, 28(6) pp. 1879​-1892​.​ DOI: https://doi.org/10.1177/0962280218777538 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​Differences in the Reponses to Apheresis Therapy of Patients With 3 Histopathologically Classified Immunopathological Patterns of Multiple Sclerosis​
    Stork, L.; Ellenberger, D. ; Beißbarth, T. ; Friede, T. ; Lucchinetti, C. F.; Brück, W.   & Metz, I. ​ (2018) 
    JAMA Neurology, 75(4) pp. 428​-435​.​ DOI: https://doi.org/10.1001/jamaneurol.2017.4842 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​A design-by-treatment interaction model for network meta-analysis and meta-regression with integrated nested Laplace approximations​
    Günhan, B. K. ; Friede, T.   & Held, L.​ (2018) 
    Research Synthesis Methods, 9(2) pp. 179​-194​.​ DOI: https://doi.org/10.1002/jrsm.1285 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy​
    Bergau, L.; Willems, R.; Sprenkeler, D. J.; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    International Journal of Cardiology, 272 pp. 102​-107​.​ DOI: https://doi.org/10.1016/j.ijcard.2018.06.103 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework​
    Gold, S. M; Enck, P.; Hasselmann, H.; Friede, T. ; Hegerl, U.; Mohr, D. C & Otte, C.​ (2017) 
    The Lancet Psychiatry, 4(9) pp. 725​-732​.​ DOI: https://doi.org/10.1016/S2215-0366(17)30153-0 
    ​Details  DOI 
  • 2017 | Book Chapter
    ​ ​Information Flows in Patient-Oriented Online Media and Scientific Research​
    Makedonski, P. ; Friede, T. ; Grabowski, J. ; Koschack, J.  & Himmel, W. ​ (2017)
    In:​Fu, Xiaoming; Luo, J. D.; Boos, Margarete​ (Eds.), Social Network Analysis – Interdisciplinary Approaches and Case Studies pp. 341​-363. ​Boca Raton: ​CRC Press.
    ​Details 
  • 2017 | Journal Article
    ​ ​Blinded sample size re-estimation in three-arm trials with ‘gold standard’ design​
    Mütze, T.   & Friede, T. ​ (2017) 
    Statistics in Medicine, 36(23) pp. 3636​-3653​.​ DOI: https://doi.org/10.1002/sim.7356 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Immunotherapies in neuromyelitis optica spectrum disorder: efficacy and predictors of response​
    Stellmann, J.-P.; Krumbholz, M.; Friede, T. ; Gahlen, A.; Borisow, N.; Fischer, K. & Hellwig, K. et al.​ (2017) 
    Journal of Neurology, Neurosurgery & Psychiatry, 88(8) pp. 639​-647​.​ DOI: https://doi.org/10.1136/jnnp-2017-315603 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Dose-finding methods for Phase I clinical trials using pharmacokinetics in small populations​
    Ursino, M.; Zohar, S.; Lentz, F.; Alberti, C.; Friede, T. ; Stallard, N. & Comets, E.​ (2017) 
    Biometrical Journal, 59(4) pp. 804​-825​.​ DOI: https://doi.org/10.1002/bimj.201600084 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Clinical trials with nested subgroups: Analysis, sample size determination and internal pilot studies​
    Placzek, M. & Friede, T. ​ (2017) 
    Statistical Methods in Medical Research, 27(11) pp. 3286​-3303​.​ DOI: https://doi.org/10.1177/0962280217696116 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Sample size re-estimation incorporating prior information on a nuisance parameter​
    Mütze, T. ; Schmidli, H. & Friede, T. ​ (2017) 
    Pharmaceutical Statistics, 17(2) pp. 126​-143​.​ DOI: https://doi.org/10.1002/pst.1837 
    ​Details  DOI 
  • 2016 | Conference Abstract
    ​ ​Apheresis therapy in multiple sclerosis patients with histopathologically classified immunopathological patterns​
    Stork, L.; Ellenberger, D. ; Beißbarth, T. ; Friede, T. ; Lucchinetti, C.; Brück, W.   & Metz, I. ​ (2016)
    Multiple Sclerosis Journal, 22 , London, ENGLAND.
    London​: Sage Publications Ltd.
    ​Details  WoS 
  • 2016 | Journal Article
    ​ ​A studentized permutation test for three-arm trials in the ‘gold standard’ design​
    Mütze, T. ; Konietschke, F. ; Munk, A.   & Friede, T. ​ (2016) 
    Statistics in Medicine, 36(6) pp. 883​-898​.​ DOI: https://doi.org/10.1002/sim.7176 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Results of medial patellofemoral ligament reconstruction compared with trochleoplasty plus individual extensor apparatus balancing in patellar instability caused by severe trochlear dysplasia: a systematic review and meta-analysis​
    Balcarek, P. ; Rehn, S.; Howells, N. R.; Eldridge, J. D.; Kita, K.; Dejour, D. & Nelitz, M. et al.​ (2016) 
    Knee Surgery, Sports Traumatology, Arthroscopy, 25(12) pp. 3869​-3877​.​ DOI: https://doi.org/10.1007/s00167-016-4365-x 
    ​Details  DOI 
  • 2016 | Journal Article | Research Paper
    ​ ​Design and analysis of three-arm trials with negative binomially distributed endpoints​
    Muetze, T. ; Munk, A.   & Friede, T. ​ (2016) 
    Statistics in Medicine, 35(4) pp. 505​-521​.​ DOI: https://doi.org/10.1002/sim.6738 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Prediction of Appropriate Shocks Using 24-Hour Holter Variables and T-Wave Alternans After First Implantable Cardioverter-Defibrillator Implantation in Patients With Ischemic or Nonischemic Cardiomyopathy​
    Seegers, J.; Bergau, L. ; Exposito, P. M.; Bauer, A.; Fischer, T. H. ; Luethje, L.   & Hasenfuß, G.  et al.​ (2016) 
    The American Journal of Cardiology, 118(1) pp. 86​-94​.​ DOI: https://doi.org/10.1016/j.amjcard.2016.04.016 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​An Unconditional Test for Change Point Detection in Binary Sequences with Applications to Clinical Registries​
    Ellenberger, D.   & Friede, T. ​ (2016) 
    Methods of Information in Medicine, 55(4) pp. 367​-372​.​ DOI: https://doi.org/10.3414/ME15-02-0020 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Monitoring of 30 marker candidates in early Parkinson disease as progression markers​
    Mollenhauer, B. ; Zimmermann, J.; Sixel-Döring, F.; Focke, N. K. ; Wicke, T.; Ebentheuer, J. & Schaumburg, M. et al.​ (2016) 
    Neurology, 87(2) pp. 168​-177​.​ DOI: https://doi.org/10.1212/WNL.0000000000002651 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Evaluation of dysphagia by novel real-time MRI​
    Olthoff, A. ; Carstens, P.-O. ; Zhang, S.; von Fintel, E. ; Friede, T. ; Lotz, J.   & Frahm, J.  et al.​ (2016) 
    Neurology, 87(20) pp. 2132​-2138​.​ DOI: https://doi.org/10.1212/WNL.0000000000003337 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators​
    Seegers, J.; Conen, D.; Jung, K. ; Bergau, L. ; Dorenkamp, M.; Luethje, L.   & Sohns, C. et al.​ (2016) 
    EP Europace, 18(8) pp. 1194​-1202​.​ DOI: https://doi.org/10.1093/europace/euv361 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis​
    Metz, I. ; Beißbarth, T. ; Ellenberger, D. ; Pache, F.; Stork, L.; Ringelstein, M. & Aktas, O. et al.​ (2016) 
    Neurology: Neuroimmunology & Neuroinflammation, 3(2) art. e204​.​ DOI: https://doi.org/10.1212/NXI.0000000000000204 
    ​Details  DOI  PMID  PMC 
  • 2015 | Conference Paper
    ​ ​Automated characterization of cell tracks and classification by using their position coordinates and velocity components​
    Islam, S.; Nietert, M. M. ; Haberl, M.; Friede, T.   & Beißbarth, T. ​ (2015)
    ​Computational Models in Biology and Medicine​, Leipzig.
    ​Details 
  • 2015 | Conference Abstract
    ​ ​Risk stratification of ICD patients for appropriate shock and mortality in a multi-centre cohort. The EU-TrigTreat study​
    Bergau, L.; Willems, R.; Tuinenburg, A. E.; Vos, M. A.; Flevari, P.; Sohns, C. & Roever, C.  et al.​ (2015)
    European Heart Journal, 36 pp. 8​-9. , London, ENGLAND.
    Oxford​: Oxford Univ Press.
    ​Details  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Scientific Versus Experiential Evidence: Discourse Analysis of the Chronic Cerebrospinal Venous Insufficiency Debate in a Multiple Sclerosis Forum.​
    Koschack, J. ; Weibezahl, L.; Friede, T. ; Himmel, W. ; Makedonski, F. D.   & Grabowski, J. ​ (2015) 
    Journal of medical Internet research, 17(7) art. e159​.​ DOI: https://doi.org/10.2196/jmir.4103 
    ​Details  DOI  PMID  PMC 
  • 2014 | Conference Abstract
    ​ ​Sex related differences in T2 lesion load in pediatric multiple sclerosis patients​
    Hummel, H. M. ; Huppke, P.; Friede, T. ; Ellenberger, D.   & Gaertner, J. ​ (2014)
    Multiple Sclerosis Journal, 20 pp. 397​-398. , Boston, MA.
    London​: Sage Publications Ltd.
    ​Details  WoS 
  • 2014 | Conference Paper
    ​ ​Arbeitsplatz-basiertes Assessment im Medizinstudium: Ist eine Multilevel-Analyse sinnvoll?​
    Himmel, W. ; Gemperli, A. & Rogausch, A.​ (2014)
    In:Friede, Tim; Hilgers, Reinhard; Minkenberg, Ralf​ (Eds.), ​KSFE 2014: Proceedings pp. 115​-124. ​18. Konferenz der SAS-Anwender in Forschung und Entwicklung​, Göttingen.
    Aachen​: Shaker.
    ​Details 
  • 2014 | Journal Article | 
    ​ ​Sources of Information and Behavioral Patterns in Online Health Forums: Observational Study (vol 16, e10, 2014)​
    Sudau, F.; Friede, T. ; Grabowski, J. ; Koschack, J. ; Makedonski, F. D.   & Himmel, W. ​ (2014) 
    Journal of Medical Internet Research, 16(1) art. e39​.​ DOI: https://doi.org/10.2196/jmir.3280 
    ​Details  DOI  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Safety relevant knowledge of orally anticoagulated patients without self-monitoring: a baseline survey in primary care​
    Chenot, J.-F.; Thanh Duc Hua, T. D. H.; Abu Abed, M.; Schneider-Rudt, H.; Friede, T. ; Schneider, S. & Vormfelde, S. V.​ (2014) 
    BMC Family Practice, 15 art. 104​.​ DOI: https://doi.org/10.1186/1471-2296-15-104 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Clinical presentation of pediatric multiple sclerosis before puberty​
    Huppke, B. ; Ellenberger, D. ; Rosewich, H. ; Friede, T. ; Gärtner, J.   & Huppke, P. ​ (2014) 
    European Journal of Neurology, 21(3) pp. 441​-446​.​ DOI: https://doi.org/10.1111/ene.12327 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | 
    ​ ​Spline-based procedures for dose-finding studies with active control​
    Helms, H.-J.; Benda, N.; Zinserling, J.; Kneib, T.   & Friede, T. ​ (2014) 
    Statistics in Medicine, 34(2) pp. 232​-248​.​ DOI: https://doi.org/10.1002/sim.6320 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Sources of Information and Behavioral Patterns in Online Health Forums: Observational Study​
    Sudau, F.; Friede, T. ; Grabowski, J. ; Koschack, J. ; Makedonski, F. D.   & Himmel, W. ​ (2014) 
    Journal of Medical Internet Research, 16(1) art. e10​.​ DOI: https://doi.org/10.2196/jmir.2875 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Educating Orally Anticoagulated Patients in Drug Safety A Cluster-Randomized Study in General Practice​
    Vormfelde, S. V.; Abu Abed, M.; Hua, T. D.; Schneider, S.; Friede, T.   & Chenot, J.-F.​ (2014) 
    Deutsches Ärzteblatt international, 111(37) pp. 607​-614​.​ DOI: https://doi.org/10.3238/arztebl.2014.0607 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Therapeutic Apheresis in Pediatric Patients with Acute CNS Inflammatory Demyelinating Disease​
    Koziolek, M. J. ; Friede, T. ; Ellenberger, D. ; Sigler, M. ; Huppke, B. ; Gärtner, J.   & Mueller, G.-A.  et al.​ (2013) 
    Blood Purification, 36(2) pp. 92​-97​.​ DOI: https://doi.org/10.1159/000354077 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Design and semiparametric analysis of non-inferiority trials with active and placebo control for censored time-to-event data​
    Kombrink, K.; Munk, A.   & Friede, T. ​ (2013) 
    Statistics in Medicine, 32(18) pp. 3055​-3066​.​ DOI: https://doi.org/10.1002/sim.5769 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper | 
    ​ ​Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype​
    Seegers, J.; Vos, M. A.; Flevari, P.; Willems, R.; Sohns, C.; Vollmann, D. & Luethje, L.  et al.​ (2012) 
    EP Europace, 14(3) pp. 416​-422​.​ DOI: https://doi.org/10.1093/europace/eur352 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | 
    ​ ​Reporting FDR analogous confidence intervals for the log fold change of differentially expressed genes​
    Jung, K. ; Friede, T.   & Beißbarth, T. ​ (2011) 
    BMC Bioinformatics, 12 art. 288​.​ DOI: https://doi.org/10.1186/1471-2105-12-288 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Practice nursed-based, individual and video-assisted patient education in oral anticoagulation - Protocol of a cluster-randomized controlled trial​
    Hua, T. D.; Vormfelde, S. V.; Abu Abed, M.; Schneider-Rudt, H.; Sobotta, P.; Friede, T.   & Chenot, J.-F.​ (2011) 
    BMC Family Practice, 12 art. 17​.​ DOI: https://doi.org/10.1186/1471-2296-12-17 
    ​Details  DOI  PMID  PMC  WoS 

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