Dr. med. Juan Manuel Maler

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  • 2021 | Journal Article | 
    ​ ​The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes​
    Oberstein, T. J.; Utz, J.; Spitzer, P.; Klafki, H. W. ; Wiltfang, J. ; Lewczuk, P.   & Kornhuber, J.  et al.​ (2021) 
    Frontiers in Molecular Neuroscience, 13.​ DOI: https://doi.org/10.3389/fnmol.2020.615740 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Serum neurofilament light chain in behavioral variant frontotemporal dementia​
    Steinacker, P. ; Anderl-Straub, S.; Diehl-Schmid, J.; Semler, E.; Uttner, I.; von Arnim, C. A. & Barthel, H. et al.​ (2018) 
    Neurology, 91(15) pp. e1390​-e1401​.​ DOI: https://doi.org/10.1212/WNL.0000000000006318 
    ​Details  DOI 
  • 2014 | Journal Article | 
    ​ ​Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides​
    Oberstein, T. J.; Spitzer, P.; Klafki, H.-W. ; Linning, P.; Neff, F.; Knölker, H.-J. & Lewczuk, P.  et al.​ (2014) 
    Neurobiology of Disease, 73 pp. 24​-35​.​ DOI: https://doi.org/10.1016/j.nbd.2014.08.031 
    ​Details  DOI 
  • 2011 | Book Chapter
    ​ ​Neurotransmitterveränderungen bei der Alzheimer Demenz​
    Kornhuber, J. ; Gundacker, I.; Maler, M. ; Otto, M.  & Wiltfang, J. ​ (2011)
    In:​Förstl, Hans; Bickel, Horst; Kurz, Alexander​ (Eds.), Alzheimer Demenz - Grundlagen, Klinik und Therapie. ​Berlin, Heidelberg: ​Springer. DOI: https://doi.org/10.1007/978-3-642-60228-3_5 
    ​Details  DOI 
  • 2008 | Journal Article
    ​ ​Neuronale Kaliumkanalöffnung durch Flupirtin: ​Opening of Neuronal K+ Channels by Flupirtine​
    Kornhuber, J. ; Maler, M. ; Wiltfang, J. ; Bleich, S. ; Degner, D.   & Rüther, E. ​ (2008) 
    Fortschritte der Neurologie · Psychiatrie, 67(10) pp. 466​-475​.​ DOI: https://doi.org/10.1055/s-2007-994997 
    ​Details  DOI 
  • 2004 | Journal Article
    ​ ​Lithium Decreases Secretion of Aβ1–42 and C-Truncated Species Aβ1–37/38/39/40 in Chicken Telencephalic Cultures but Specifically Increases Intracellular Aβ1–38​
    Esselmann, H. ; Maler, J. M. ; Kunz, N. ; Otto, M. ; Paul, S. ; Lewczuk, P.   & Rüther, E.  et al.​ (2004) 
    Neurodegenerative Diseases, 1(4-5) pp. 236​-241​.​ DOI: https://doi.org/10.1159/000080992 
    ​Details  DOI 
  • 2004 | Journal Article
    ​ ​Electrophoretic separation of amyloid β peptides in plasma​
    Lewczuk, P. ; Esselmann, H. ; Bibl, M. ; Paul, S.; Svitek, J.; Miertschischk, J. & Meyrer, R. et al.​ (2004) 
    ELECTROPHORESIS, 25(20) pp. 3336​-3343​.​ DOI: https://doi.org/10.1002/elps.200406068 
    ​Details  DOI 
  • 2004 | Journal Article
    ​ ​Tau Protein Phosphorylated at Threonine 181 in CSF as a Neurochemical Biomarker in Alzheimer's Disease: ​Original Data and Review of the Literature​
    Lewczuk, P. ; Esselmann, H. ; Bibl, M. ; Beck, G.; Maler, J. M. ; Otto, M.   & Kornhuber, J.  et al.​ (2004) 
    Journal of Molecular Neuroscience, 23(1-2) pp. 115​-122​.​ DOI: https://doi.org/10.1385/jmn:23:1-2:115 
    ​Details  DOI  PMID  PMC 
  • 2004 | Journal Article
    ​ ​Amyloid β peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ionization time-of-flight mass spectrometry: evidence of novel biomarkers in Alzheimer's disease​
    Lewczuk, P. ; Esselmann, H. ; Groemer, T. W.; Bibl, M. ; Maler, J. M. ; Steinacker, P.   & Otto, M.  et al.​ (2004) 
    Biological Psychiatry, 55(5) pp. 524​-530​.​ DOI: https://doi.org/10.1016/j.biopsych.2003.10.014 
    ​Details  DOI  PMID  PMC 
  • 2003 | Journal Article
    ​ ​Highly conserved and disease-specific patterns of carboxyterminally truncated Aβ peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation​
    Wiltfang, J. ; Esselmann, H. ; Bibl, M. ; Smirnov, A. ; Otto, M. ; Paul, S.   & Schmidt, B.  et al.​ (2003) 
    Journal of Neurochemistry, 81(3) pp. 481​-496​.​ DOI: https://doi.org/10.1046/j.1471-4159.2002.00818.x 
    ​Details  DOI 
  • 2003 | Journal Article
    ​ ​Homocysteine induces cell death of rat astrocytes in vitro​
    Maler, J. M. ; Seifert, W.; Hüther, G. ; Wiltfang, J. ; Rüther, E. ; Kornhuber, J.   & Bleich, S. ​ (2003) 
    Neuroscience Letters, 347(2) pp. 85​-88​.​ DOI: https://doi.org/10.1016/s0304-3940(03)00655-4 
    ​Details  DOI  PMID  PMC 
  • 2002 | Journal Article
    ​ ​Glutamaterge Neurotransmission bei Schizophrenien​
    Bleich, S. ; Bleich, K.; Wiltfang, J. ; Maler, J. M.   & Kornhuber, J. ​ (2002) 
    Fortschritte der Neurologie · Psychiatrie, 69(SH2) pp. 56​-61​.​ DOI: https://doi.org/10.1055/s-2001-16531 
    ​Details  DOI 
  • 2001 | Journal Article
    ​ ​Molecular Biology of Alzheimer’s Dementia and Its Clinical Relevance to Early Diagnosis and New Therapeutic Strategies​
    Wiltfang, J. ; Esselmann, H. ; Maler, J. M. ; Bleich, S. ; Hüther, G.   & Kornhuber, J. ​ (2001) 
    Gerontology, 47(2) pp. 65​-71​.​ DOI: https://doi.org/10.1159/000052775 
    ​Details  DOI  PMID  PMC 
  • 2000 | Journal Article
    ​ ​Elevated Homocysteine Levels in Alcohol Withdrawal​
    Bleich, S. ; Degner, D. ; Wiltfang, J. ; Maler, J. M. ; Niedmann, P. ; Cohrs, S.   & Mangholz, A.  et al.​ (2000) 
    Alcohol and Alcoholism, 35(4) pp. 351​-354​.​ DOI: https://doi.org/10.1093/alcalc/35.4.351 
    ​Details  DOI  PMID  PMC 

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