Prof. Dr. Leif Saager

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  • 2022 | Journal Article | Research Paper | 
    ​ ​Target insertion depth of nasopharyngeal temperature probes in children: A prospective observational study analyzing magnetic resonance images​
    Miller, C.; Asendorf, T. ; Ernst, M.; von Gottberg, P.; Richter, J.; Bräuer, A.   & Saager, L.  et al.​ (2022) 
    Pediatric Anesthesia, 32(9) pp. 1054​-1061​.​ DOI: https://doi.org/10.1111/pan.14504 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article
    ​ ​The role of the TMS parameters for activation of the corticospinal pathway to the diaphragm​
    Chakalov, I.; Antal, A.; Eckardt, S. S.; Paulus, W.; Saager, L. ; Meissner, K.   & Bähr, M. et al.​ (2022) 
    Clinical Neurophysiology, 138 pp. 173​-185​.​ DOI: https://doi.org/10.1016/j.clinph.2022.03.019 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Incidence of Sedation-Related Adverse Events during ERCP with Anesthesia Assistance: A Multicenter Observational Study​
    Cummings, L. C.; Liang, C.; Mascha, E. J.; Saager, L. ; Smith, Z. L.; Bhavani, S. & Vargo, J. J. et al.​ (2022) 
    Gastrointestinal Endoscopy,.​ DOI: https://doi.org/10.1016/j.gie.2022.03.023 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper
    ​ ​Epidural Needle Guidance Using Viscoelastic Tissue Response​
    Simpson, B. S.; Burns, M.; Dick, R. P. & Saager, L. ​ (2022) 
    IEEE Journal of Translational Engineering in Health and Medicine, 10 pp. 1​-11​.​ DOI: https://doi.org/10.1109/JTEHM.2022.3152391 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Association of Anesthesiologist Staffing Ratio With Surgical Patient Morbidity and Mortality​
    Burns, M. L.; Saager, L. ; Cassidy, R. B.; Mentz, G.; Mashour, G. A. & Kheterpal, S.​ (2022) 
    JAMA Surgery,.​ DOI: https://doi.org/10.1001/jamasurg.2022.2804 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Mechanical power ratio and respiratory treatment escalation in COVID-19 pneumonia: a secondary analysis of a prospectively enrolled cohort​
    Gattarello, S.; Coppola, S.; Chiodaroli, E.; Pozzi, T.; Camporota, L.; Saager, L.   & Chiumello, D. et al.​ (2022) 
    Anesthesiology, 138 pp. 289​-298​.​ DOI: https://doi.org/10.1097/ALN.0000000000004465 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Outlying End-Tidal Carbon Dioxide During General Anesthesia Is Associated With Postoperative Pulmonary Complications: A Multicenter Retrospective Observational Study From US Hospitals Between 2010 and 2017​
    Akkermans, A.; van Waes, J. A.; Kheterpal, S.; Pasma, W.; Saager, L. ; Thompson, A. & van Klei, W. A.​ (2022) 
    Anesthesia & Analgesia, 135(2) pp. 341​-353​.​ DOI: https://doi.org/10.1213/ANE.0000000000006062 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​End-tidal to arterial PCO2 ratio: a bedside meter of the overall gas exchanger performance​
    Bonifazi, M.; Romitti, F. ; Busana, M.; Palumbo, M. M.; Steinberg, I.; Gattarello, S. & Palermo, P. et al.​ (2021) 
    Intensive Care Medicine Experimental, 9 art. 21​.​ DOI: https://doi.org/10.1186/s40635-021-00377-9 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | 
    ​ ​Opioid-induced respiratory depression increases hospital costs and length of stay in patients recovering on the general care floor​
    Khanna, A. K.; Saager, L. ; Bergese, S. D.; Jungquist, C. R.; Morimatsu, H.; Uezono, S. & Ti, L. K. et al.​ (2021) 
    BMC Anesthesiology, 21(1).​ DOI: https://doi.org/10.1186/s12871-021-01307-8 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Multicenter Perioperative Outcomes Group Enhanced Observation Study Postoperative Pain Profiles, Analgesic Use, and Transition to Chronic Pain and Excessive and Prolonged Opioid Use Patterns Methodology​
    Stuart, A. R.; Kuck, K.; Naik, B. I.; Saager, L. ; Pace, N. L.; Domino, K. B. & Posner, K. L. et al.​ (2020) 
    Anesthesia & Analgesia, 130(6) pp. 1702​-1708​.​ DOI: https://doi.org/10.1213/ANE.0000000000004568 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Classification of Current Procedural Terminology Codes from Electronic Health Record Data Using Machine Learning​
    Burns, M. L.; Mathis, M. R.; Vandervest, J.; Tan, X.; Lu, B.; Colquhoun, D. A. & Shah, N. et al.​ (2020) 
    Anesthesiology, 132(4) pp. 738​-749​.​ DOI: https://doi.org/10.1097/ALN.0000000000003150 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Utilization Patterns of Perioperative Neuromuscular Blockade Reversal in the United States: A Retrospective Observational Study From the Multicenter Perioperative Outcomes Group​
    Dubovoy, T. Z.; Saager, L. ; Shah, N. J.; Colquhoun, D. A.; Mathis, M. R.; Kapeles, S. & Mentz, G. et al.​ (2020) 
    Anesthesia & Analgesia, 131(5) pp. 1510​-1519​.​ DOI: https://doi.org/10.1213/ANE.0000000000005080 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Prediction of Opioid-Induced Respiratory Depression on Inpatient Wards Using Continuous Capnography and Oximetry: An International Prospective, Observational Trial​
    Khanna, A. K.; Bergese, S. D.; Jungquist, C. R.; Morimatsu, H.; Uezono, S.; Lee, S. & Ti, L. K. et al.​ (2020) 
    Anesthesia & Analgesia, 131(4) pp. 1012​-1024​.​ DOI: https://doi.org/10.1213/ANE.0000000000004788 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Considerations for Integration of Perioperative Electronic Health Records Across Institutions for Research and Quality Improvement​
    Colquhoun, D. A.; Shanks, A. M.; Kapeles, S. R.; Shah, N.; Saager, L. ; Vaughn, M. T. & Buehler, K. et al.​ (2020) 
    Anesthesia & Analgesia, 130(5) pp. 1133​-1146​.​ DOI: https://doi.org/10.1213/ANE.0000000000004489 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Elektrokonvulsionstherapie in der Schwangerschaft: Fallbericht und interdisziplinäre Behandlungsvorschläge​
    Zilles-Wegner, D.; Trost, S. ; Walliser, K. ; Saager, L. ; Horn, S.   & Ernst, M.​ (2020) 
    Der Nervenarzt, 92(1) pp. 50​-56​.​ DOI: https://doi.org/10.1007/s00115-020-00960-7 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper
    ​ ​Incidence of insufficient intraoperative neuromuscular paralysis. A retrospective registry analysis​
    Hesler, B. D.; Turan, A.; Egan, C. R.; Yang, D.; Mascha, E. J.; Devine, S. & Kurz, A. et al.​ (2019) 
    Journal of Clinical Anesthesia, 56 pp. 77​-84​.​ DOI: https://doi.org/10.1016/j.jclinane.2019.01.023 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Incidence, risk factors, and consequences of residual neuromuscular block in the United States: The prospective, observational, multicenter RECITE-US study​
    Saager, L. ; Maiese, E. M.; Bash, L. D.; Meyer, T. A.; Minkowitz, H.; Groudine, S. & Philip, B. K. et al.​ (2019) 
    Journal of Clinical Anesthesia, 55 pp. 33​-41​.​ DOI: https://doi.org/10.1016/j.jclinane.2018.12.042 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Incidence of complications in the post-anesthesia care unit and associated healthcare utilization in patients undergoing non-cardiac surgery requiring neuromuscular blockade 2005-2013: A single center study​
    Belcher, A. W.; Leung, S.; Cohen, B.; Yang, D.; Mascha, E. J.; Turan, A. & Saager, L.  et al.​ (2017) 
    Journal of Clinical Anesthesia, 43 pp. 33​-38​.​ DOI: https://doi.org/10.1016/j.jclinane.2017.09.005 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Research Paper | 
    ​ ​The accuracy of a disposable noninvasive core thermometer​
    Kimberger, O.; Saager, L. ; Egan, C.; Sanchez, I. P.; Dizili, S.; Koch, J. & Kurz, A.​ (2013) 
    Canadian Journal of Anesthesia, 60(12) pp. 1190​-1196​.​ DOI: https://doi.org/10.1007/s12630-013-0047-z 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Research Paper
    ​ ​The association between preoperative anemia and 30-day mortality and morbidity in noncardiac surgical patients​
    Saager, L. ; Turan, A.; Reynolds, L. F.; Dalton, J. E.; Mascha, E. J. & Kurz, A.​ (2013) 
    Anesthesia & Analgesia, 117(4) pp. 909​-915​.​ DOI: https://doi.org/10.1213/ANE.0b013e31828b347d 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Research Paper
    ​ ​Statistical grand rounds: understanding the mechanism: mediation analysis in randomized and nonrandomized studies​
    Mascha, E. J.; Dalton, J. E.; Kurz, A. & Saager, L. ​ (2013) 
    Anesthesia & Analgesia, 117(4) pp. 980​-994​.​ DOI: https://doi.org/10.1213/ANE.0b013e3182a44cb9 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Morbidity and mortality after massive transfusion in patients undergoing non-cardiac surgery​
    Turan, A.; Yang, D.; Bonilla, A.; Shiba, A.; Sessler, D. I.; Saager, L.   & Kurz, A.​ (2013) 
    Canadian Journal of Anesthesia, 60(8) pp. 761​-770​.​ DOI: https://doi.org/10.1007/s12630-013-9937-3 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Research Paper
    ​ ​The clinical quandary of counseling the moribund critical care patient-a registry analysis of postsurgical outcomes​
    Saager, L. ; Hesler, B. D.; Reynolds, L. F.; Deogaonkar, A.; Dalton, J. E.; Kurz, A. & Turan, A.​ (2013) 
    Journal of Critical Care, 28(4) pp. 421​-426​.​ DOI: https://doi.org/10.1016/j.jcrc.2012.10.068 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Research Paper
    ​ ​The association between nitrous oxide and postoperative mortality and morbidity after noncardiac surgery​
    Turan, A.; Mascha, E. J.; You, J.; Kurz, A.; Shiba, A.; Saager, L.   & Sessler, D. I.​ (2013) 
    Anesthesia & Analgesia, 116(5) pp. 1026​-1033​.​ DOI: https://doi.org/10.1213/ANE.0b013e31824590a5 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Research Paper
    ​ ​Erythrocyte storage duration is not associated with increased mortality in noncardiac surgical patients: a retrospective analysis of 6,994 patients​
    Saager, L. ; Turan, A.; Dalton, J. E.; Figueroa, P. I.; Sessler, D. I. & Kurz, A.​ (2013) 
    Anesthesiology, 118(1) pp. 51​-58​.​ DOI: https://doi.org/10.1097/ALN.0b013e3182746ba4 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Research Paper
    ​ ​Low vitamin D concentration is not associated with increased mortality and morbidity after cardiac surgery​
    Turan, A.; Grady, M.; You, J.; Mascha, E. J.; Keeyapaj, W.; Komatsu, R. & Bashour, C. A. et al.​ (2013) 
    PLoS One, 8(5) art. e63831​.​ DOI: https://doi.org/10.1371/journal.pone.0063831 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article | Research Paper
    ​ ​Lack of value of scheduling processes to move cases from a heavily used main campus to other facilities within a health care system​
    Sulecki, L.; Dexter, F.; Zura, A.; Saager, L.   & Epstein, R. H.​ (2012) 
    Anesthesia & Analgesia, 115(2) pp. 395​-401​.​ DOI: https://doi.org/10.1213/ANE.0b013e3182575e05 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article | Research Paper | 
    ​ ​Chemotherapy within 30 days before surgery does not augment postoperative mortality and morbidity​
    Turan, A.; Shao, D.; Salmasi, V.; Honar, H.; Atim, A.; Dalton, J. E. & Saager, L.  et al.​ (2012) 
    Canadian Journal of Anesthesia, 59(8) pp. 758​-765​.​ DOI: https://doi.org/10.1007/s12630-012-9735-3 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article | Research Paper
    ​ ​Hospital stay and mortality are increased in patients having a "triple low" of low blood pressure, low bispectral index, and low minimum alveolar concentration of volatile anesthesia​
    Sessler, D. I.; Sigl, J. C.; Kelley, S. D.; Chamoun, N. G.; Manberg, P. J.; Saager, L.   & Kurz, A. et al.​ (2012) 
    Anesthesiology, 116(6) pp. 1195​-1203​.​ DOI: https://doi.org/10.1097/ALN.0b013e31825683dc 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article | Research Paper
    ​ ​Targeted prophylaxis of postoperative delirium​
    Saager, L.   & Sessler, D. I.​ (2012) 
    Anesthesiology, 116(5) pp. 975​-976​.​ DOI: https://doi.org/10.1097/ALN.0b013e318251531f 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article | Research Paper
    ​ ​Angiotensin converting enzyme inhibitors are not associated with respiratory complications or mortality after noncardiac surgery​
    Turan, A.; You, J.; Shiba, A.; Kurz, A.; Saager, L.   & Sessler, D. I.​ (2012) 
    Anesthesia & Analgesia, 114(3) pp. 552​-560​.​ DOI: https://doi.org/10.1213/ANE.0b013e318241f6af 
    ​Details  DOI  PMID  PMC 
  • 2011 | Journal Article | Research Paper
    ​ ​Operation timing and 30-day mortality after elective general surgery​
    Sessler, D. I.; Kurz, A.; Saager, L.   & Dalton, J. E.​ (2011) 
    Anesthesia & Analgesia, 113(6) pp. 1423​-1428​.​ DOI: https://doi.org/10.1213/ANE.0b013e3182315a6d 
    ​Details  DOI  PMID  PMC 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Mitigating preventable chronic disease: Progress report of the Cleveland Clinic's Lifestyle 180 program​
    Ricanati, E. H. W.; Golubić, M.; Yang, D.; Saager, L. ; Mascha, E. J. & Roizen, M. F.​ (2011) 
    Nutrition & Metabolism, 8(1) pp. 83​.​ DOI: https://doi.org/10.1186/1743-7075-8-83 
    ​Details  DOI  PMID  PMC 
  • 2011 | Journal Article | Research Paper
    ​ ​Consequences of succinylcholine administration to patients using statins​
    Turan, A.; Mendoza, M. L.; Gupta, S.; You, J.; Gottlieb, A.; Chu, W. & Saager, L.  et al.​ (2011) 
    Anesthesiology, 115(1) pp. 28​-35​.​ DOI: https://doi.org/10.1097/ALN.0b013e31822079fa 
    ​Details  DOI  PMID  PMC 
  • 2011 | Journal Article | Research Paper
    ​ ​Development and validation of a risk quantification index for 30-day postoperative mortality and morbidity in noncardiac surgical patients​
    Dalton, J. E.; Kurz, A.; Turan, A.; Mascha, E. J.; Sessler, D. I. & Saager, L. ​ (2011) 
    Anesthesiology, 114(6) pp. 1336​-1344​.​ DOI: https://doi.org/10.1097/ALN.0b013e318219d5f9 
    ​Details  DOI  PMID  PMC 
  • 2011 | Journal Article | Research Paper
    ​ ​Pre-existing do-not-resuscitate orders are not associated with increased postoperative morbidity at 30 days in surgical patients​
    Saager, L. ; Kurz, A.; Deogaonkar, A.; You, J.; Mascha, E. J.; Jahan, A. & Turner, P. L. et al.​ (2011) 
    Critical Care Medicine, 39(5) pp. 1036​-1041​.​ DOI: https://doi.org/10.1097/CCM.0b013e31820eb4fc 
    ​Details  DOI  PMID  PMC 
  • 2011 | Journal Article | Research Paper
    ​ ​A nomogram for predicting surgical complications in bariatric surgery patients​
    Turner, P. L.; Saager, L. ; Dalton, J.; Abd-Elsayed, A.; Roberman, D.; Melara, P. & Kurz, A. et al.​ (2011) 
    Obesity surgery : including laparoscopy and allied care, 21(5) pp. 655​-662​.​ DOI: https://doi.org/10.1007/s11695-010-0325-6 
    ​Details  DOI  PMID  PMC 
  • 2011 | Journal Article | Research Paper
    ​ ​Smoking and perioperative outcomes​
    Turan, A.; Mascha, E. J.; Roberman, D.; Turner, P. L.; You, J.; Kurz, A. & Sessler, D. I. et al.​ (2011) 
    Anesthesiology, 114(4) pp. 837​-846​.​ DOI: https://doi.org/10.1097/ALN.0b013e318210f560 
    ​Details  DOI  PMID  PMC 
  • 2011 | Journal Article | Research Paper
    ​ ​Successful extubation in the operating room after infratentorial craniotomy: the Cleveland Clinic experience​
    Cata, J. P.; Saager, L. ; Kurz, A. & Avitsian, R.​ (2011) 
    Journal of Neurosurgical Anesthesiology, 23(1) pp. 25​-29​.​ DOI: https://doi.org/10.1097/ANA.0b013e3181eee548 
    ​Details  DOI  PMID  PMC 
  • 2010 | Journal Article | Research Paper
    ​ ​Preoperative prolonged steroid use is not associated with intraoperative blood transfusion in noncardiac surgical patients​
    Turan, A.; Dalton, J. E.; Turner, P. L.; Sessler, D. I.; Kurz, A. & Saager, L. ​ (2010) 
    Anesthesiology, 113(2) pp. 285​-291​.​ DOI: https://doi.org/10.1097/ALN.0b013e3181e6a195 
    ​Details  DOI  PMID  PMC 
  • 2010 | Journal Article | Research Paper
    ​ ​Q: Should we routinely screen for hypercapnia in sleep apnea patients before elective noncardiac surgery?​
    Mokhlesi, B.; Saager, L.   & Kaw, R.​ (2010) 
    Cleveland clinic journal of medicine : CCJM, 77(1) pp. 60​-61​.​ DOI: https://doi.org/10.3949/ccjm.77a.09105 
    ​Details  DOI  PMID  PMC 
  • 2009 | Journal Article | Research Paper
    ​ ​Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness​
    Avidan, M. S.; Searleman, A. C.; Storandt, M.; Barnett, K.; Vannucci, A.; Saager, L.   & Xiong, C. et al.​ (2009) 
    Anesthesiology, 111(5) pp. 964​-970​.​ DOI: https://doi.org/10.1097/ALN.0b013e3181bc9719 
    ​Details  DOI  PMID  PMC 
  • 2009 | Journal Article | Research Paper
    ​ ​Prevalence of undiagnosed obstructive sleep apnea among adult surgical patients in an academic medical center​
    Finkel, K. J.; Searleman, A. C.; Tymkew, H.; Tanaka, C. Y.; Saager, L. ; Safer-Zadeh, E. & Bottros, M. et al.​ (2009) 
    Sleep Medicine, 10(7) pp. 753​-758​.​ DOI: https://doi.org/10.1016/j.sleep.2008.08.007 
    ​Details  DOI  PMID  PMC 
  • 2008 | Journal Article | Research Paper
    ​ ​A randomized study in diabetic patients undergoing cardiac surgery comparing computer-guided glucose management with a standard sliding scale protocol​
    Saager, L. ; Collins, G. L.; Burnside, B.; Tymkew, H.; Zhang, L.; Jacobsohn, E. & Avidan, M.​ (2008) 
    Journal of Cardiothoracic and Vascular Anesthesia, 22(3) pp. 377​-382​.​ DOI: https://doi.org/10.1053/j.jvca.2007.09.013 
    ​Details  DOI  PMID  PMC 
  • 2008 | Journal Article | Research Paper
    ​ ​Anesthesia awareness and the bispectral index​
    Avidan, M. S.; Zhang, L.; Burnside, B. A.; Finkel, K. J.; Searleman, A. C.; Selvidge, J. A. & Saager, L.  et al.​ (2008) 
    The New England Journal of Medicine, 358(11) pp. 1097​-1108​.​ DOI: https://doi.org/10.1056/NEJMoa0707361 
    ​Details  DOI  PMID  PMC 
  • 2007 | Journal Article | Research Paper
    ​ ​Atrial electrocardiogram for verification of correct central venous catheter placement​
    Saager, L. ; Wiesner, E.; Rothhammer, A. & Pestel, G.​ (2007) 
    Anesthesia & Analgesia, 105(5).​ DOI: https://doi.org/10.1213/01.ane.0000287013.96196.5b 
    ​Details  DOI  PMID  PMC 
  • 2007 | Journal Article | Discussion
    ​ ​Der zentrale Venenkatheter: ​Zugang über die Vena subclavia​
    Saager, L.   & Pestel, G.​ (2007) 
    Deutsche medizinische Wochenschrift, 132(21) pp. 1180​-1180​.​ DOI: https://doi.org/10.1055/s-2007-979397 
    ​Details  DOI  PMID  PMC 
  • 2005 | Journal Article | Research Paper
    ​ ​Remifentanil–propofol versus sufentanil–propofol anaesthesia for supratentorial craniotomy: a randomized trial​
    Gerlach, K.; Uhlig, T.; Hüppe, M.; Nowak, G.; Schmitz, A.; Saager, L.   & Grasteit, A. et al.​ (2005) 
    European Journal of Anaesthesiology, 20(10) pp. 813​-820​.​ DOI: https://doi.org/10.1017/S0265021503001315 
    ​Details  DOI 
  • 2002 | Journal Article | Research Paper
    ​ ​Remifentanil-clonidine-propofol versus sufentanil-propofol anesthesia for coronary artery bypass surgery​
    Gerlach, K.; Uhlig, T.; Hüppe, M.; Kraatz, E.; Saager, L. ; Schmitz, A. & Dörges, V. et al.​ (2002) 
    Journal of Cardiothoracic and Vascular Anesthesia, 16(6) pp. 703​-708​.​ DOI: https://doi.org/10.1053/jcan.2002.128415 
    ​Details  DOI  PMID  PMC 

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