Suche
1-10 von 45 Publikationen
Zeitschriftenartikel
EndophilinAs regulate endosomal sorting of BDNF-TrkB to mediate survival signaling in hippocampal neurons
(2017)
The sorting of activated receptors into distinct endosomal compartments is essential to activate specific signaling cascades and cellular events including growth and survival. However, the proteins involved in this sorting ...
Zeitschriftenartikel
Dlk1 promotes a fast motor neuron biophysical signature required for peak force execution.
(2014-03-14)
Motor neurons, which relay neural commands to drive skeletal muscle movements, encompass types ranging from "slow" to "fast," whose biophysical properties govern the timing, gradation, and amplitude of muscle force. Here ...
Zeitschriftenartikel
“Self” versus “Non-Self” Connectivity Dictates Properties of Synaptic Transmission and Plasticity
(2013-04-29)
Autapses are connections between a neuron and itself. These connections are morphologically similar to ‘‘normal’’ synapses
between two different neurons, and thus were long thought to have similar properties of synaptic ...
Zeitschriftenartikel
Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits
(2017)
Local endocytic events involving receptors for axon guidance cues play a central role in
controlling growth cone behaviour. Yet, little is known about the fate of internalized receptors,
and whether the sorting events ...
Zeitschriftenartikel
IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses.
(2016-02-03)
The insulin-like growth factor-1 receptor (IGF-1R) signaling is a key regulator of lifespan, growth, and development. While reduced IGF-1R signaling delays aging and Alzheimer's disease progression, whether and how it ...
Zeitschriftenartikel
Characterization of Eag1 Channel Lateral Mobility in Rat Hippocampal Cultures by Single-Particle-Tracking with Quantum Dots
(2010-01-25)
Voltage-gated ion channels are main players involved in fast synaptic events. However, only slow intracellular mechanisms
have so far been described for controlling their localization as real-time visualization of endogenous ...
Zeitschriftenartikel
TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan.
(2017)
Protein quality control mechanisms, required for normal cellular functioning, encompass multiple functions related to protein production and maintenance. However, the existence of communication between proteostasis and ...
Zeitschriftenartikel
Neurofeedback of Slow Cortical Potentials in Children with Attention-Deficit/Hyperactivity Disorder: A Multicenter Randomized Trial Controlling for Unspecific Effects.
(2017)
Background: Neurofeedback (NF) in children with attention-deficit/hyperactivity disorder (ADHD) has been investigated in a series of studies over the last years. Previous studies did not unanimously support NF as a treatment ...
Zeitschriftenartikel
Retinal Remodeling: Concerns, Emerging Remedies and Future Prospects.
(2016)
Deafferentation results not only in sensory loss, but also in a variety of alterations in the postsynaptic circuitry. These alterations may have detrimental impact on potential treatment strategies. Progressive loss of ...
Zeitschriftenartikel
Ocular Dominance Plasticity after Stroke Was Preserved in PSD-95 Knockout Mice.
(2016)
Neuronal plasticity is essential to enable rehabilitation when the brain suffers from injury, such as following a stroke. One of the most established models to study cortical plasticity is ocular dominance (OD) plasticity ...