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201-208 von 208 Publikationen
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Dose-dependent effect of cannabinoid WIN-55,212-2 on myelin repair following a demyelinating insult
(2020)
Dysfunctions in the endocannabinoid system have been associated with experimental animal models and multiple sclerosis patients. Interestingly, the endocannabinoid system has been reported to confer neuroprotection against ...
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Increased alpha-synuclein tear fluid levels in patients with Parkinson’s disease
(2020)
The objective of the study was to estimate if altered levels of alpha-synuclein can be detected in tear fluid of patients with Parkinson’s disease (PD). Therefore, tear fluid samples of 75 PD patients, 75 control subjects ...
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The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration
(2018)
Mutations in the gene encoding DJ-1 are associated with autosomal recessive forms of Parkinson’s disease (PD). DJ-1 plays a role in protection from oxidative stress, but how it functions as an “upstream” oxidative stress ...
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Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models
(2017)
Among the familial forms of amyotrophic lateral sclerosis (fALS), 20% are associated with the Cu,Zn-superoxide dismutase (Sod1). fALS is characterized by the accumulation of aggregated proteins and the increase in oxidative ...
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The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus
(2017)
Background:
Type II diabetes is an important health problem with a complex connection to obesity, leading to a broad range of cardiovascular complications. Insulin therapy often results in weight gain and does not always ...
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Divergent axial morphogenesis and early shh expression in vertebrate prospective floor plate
(BioMed Central, 2018-01-31)
Abstract
Background
The notochord has organizer properties and is required for floor plate induction and dorsoventral patterning of the neural tube. This activity has been ...
Zeitschriftenartikel
Membrane binding, internalization, and sorting of alpha-synuclein in the cell
(BioMed Central, 2018)
Alpha-synuclein (aSyn) plays a crucial role in Parkinson’s disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions. While the function of aSyn is thought to be related ...