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Journal Article
Genetic ablation of VIAAT in glycinergic neurons causes a severe respiratory phenotype and perinatal death
(2014)
Both glycinergic and GABAergic neurons require the vesicular inhibitory amino acid
transporter (VIAAT) for synaptic vesicle filling. Presynaptic GABA concentrations are
determined by the GABA synthesizing enzymes glutamate ...
Journal Article
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies
(2019)
Alpha-synuclein (aSyn) accumulates in intracellular inclusions in synucleinopathies, but the molecular mechanisms leading to disease are unclear. We identify the 10 kDa heat shock protein (HSP10) as a mediator of aSyn-induced ...