11-20 von 237 Publikationen
A Novel Sequence-Based Feature for the Identification of DNA-Binding Sites in Proteins Using Jensen–Shannon Divergence
The knowledge of protein-DNA interactions is essential to fully understand the molecular activities of life. Many research groups have developed various tools which are either structure- or sequence-based approaches to ...
Modeling spike timing dependent plasticity with a retrograde transmitter
Behavioral inhibition during reversal learning in the limbic system: a computational model
Some remarks on residual-based stabilisation of inf-sup stable discretisations of the generalised oseen problem
We consider residual-based stabilised nite element methods for the generalised Oseen problem. The unique solvability based on a modi ed stability condition and an error estimate are proved for inf-sup stable discretisations ...
Scipio: using protein sequences to determine the precise exon/intron structures of genes and their orthologs in closely related species.
BACKGROUND: For many types of analyses, data about gene structure and locations of non-coding regions of genes are required. Although a vast amount of genomic sequence data is available, precise annotation of genes is ...
Gene prediction in eukaryotes with a generalized hidden Markov model that uses hints from external sources.
BACKGROUND: In order to improve gene prediction, extrinsic evidence on the gene structure can be collected from various sources of information such as genome-genome comparisons and EST and protein alignments. However, such ...
Distribution and evolution of stable single α-helices (SAH domains) in myosin motor proteins
Stable single-alpha helices (SAHs) are versatile structural elements in many prokaryotic and eukaryotic proteins acting as semi-flexible linkers and constant force springs. This way SAH-domains function as part of the lever ...
A 5.875-approximation for the Traveling Tournament Problem
In this paper we propose an approximation for the Traveling Tournament Problem which is the problem of designing a schedule for a sports league consisting of a set of teams T such that the total traveling costs of the ...
PC-TraFF: identification of potentially collaborating transcription factors using pointwise mutual information
Abstract Background Transcription factors (TFs) are important regulatory proteins that govern transcriptional regulation. Today, it is known that in higher organisms different TFs have to cooperate rather than acting ...
Computer Solution to the Game of Pure Strategy
We numerically solve the classical “Game of Pure Strategy” using linear programming. We notice an intricate even-odd behaviour in the results of our computations that seems to encourage odd or maximal bids.