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571-580 von 601 Publikationen
Zeitschriftenartikel
Yeast Prp2 liberates the 5′ splice site and the branch site adenosine for catalysis of pre-mRNA splicing
(2017)
The RNA helicase Prp2 facilitates the remodeling of the spliceosomal Bact complex to the catalytically activated B* complex just before step one of splicing. As a high-resolution cryo-EM structure of the B* complex is ...
Zeitschriftenartikel
Synthesis of benzannelated sultams by intramolecular Pd-catalyzed arylation of tertiary sulfonamides
(2017)
A new and efficient approach to five- and six-membered benzannelated sultams by intramolecular C-arylation of tertiary
1-(methoxycarbonyl)methanesulfonamides under palladium catalysis is described. In case of the ...
Zeitschriftenartikel
Expanding the Scope of Cu(I) Catalyzed “Click Chemistry” with Abnormal NHCs: Three-Fold Click to Tris-Triazoles
(2017)
Cationic copper(I) complexes [Cu(aIPrPh)(IPr)]I (3) and [Cu(aIPrPh)2]I (4) featuring
an abnormal N-heterocyclic carbene (aNHC) (aIPrPh = 1,3-bis(2,6-diisopropylphenyl)-2-phenylimidazol-
4-ylidene) and/or an NHC (IPr = ...
Zeitschriftenartikel
Non-merohedral twinning: from minerals to proteins
(2019)
In contrast to twinning by merohedry, the reciprocal lattices of the different domains of non-merohedral twins do not overlap exactly. This leads to three kinds of reflections: reflections with no overlap, reflections with ...
Zeitschriftenartikel
Visible‐Light‐Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides
(2019)
Dearomatisation of indole derivatives to the corresponding isatin derivatives has been achieved with the aid of visible light and oxygen. It should be noted that isatin derivatives are highly important for the synthesis ...
Zeitschriftenartikel
Ruthenium(II)‐Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C−H Deuteration and C−H Tritiation
(2019)
Well-defined ruthenium(II) biscarboxylate complexes enabled selective ortho-deuteration with weakly-coordinating, synthetically useful carboxylic acid with outstanding levels of isotopic labeling. The robust nature of the ...
Zeitschriftenartikel
Viscoelastic properties of vimentin originate from nonequilibrium conformational changes
(2018)
Structure and dynamics of living matter rely on design principles fundamentally different from concepts of traditional
material science. Specialized intracellular filaments in the cytoskeleton permit living systems to ...
Zeitschriftenartikel
Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain
(2017)
The mechanical properties of eukaryotic cells are to a great extent determined by the cytoskeleton, a composite network of different filamentous proteins. Among these, intermediate filaments (IFs) are exceptional in their ...
Zeitschriftenartikel
π‐Extended Polyaromatic Hydrocarbons by Sustainable Alkyne Annulations through Double C−H/N−H Activation
(2019)
The widespread applications of substituted diketopyrrolopyrroles (DPPs) call for the development of efficient methods for their modular assembly. Herein, we present a π-expansion strategy for polyaromatic hydrocarbons ...
Zeitschriftenartikel
Iron catalyzed hydrogenation and electrochemical reduction of CO 2 : The role of functional ligands
(2018)