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A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells.
(Public Library of Science, 2009)
Extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) are members of the MAPK family and participate in the transduction of stimuli in cellular responses. Their long-term actions are accomplished by promoting the ...
Cellular prion protein mediates early apoptotic proteome alternation and phospho-modification in human neuroblastoma cells
Anti-apoptotic properties of physiological and elevated levels of the cellular prion protein (PrPc) under stress conditions are well documented. Yet, detrimental effects of elevated PrPc levels under stress conditions, ...
NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation.
Acinar transdifferentiation toward a duct-like phenotype constitutes the defining response of acinar cells to external stress signals and is considered to be the initial step in pancreatic carcinogenesis. Despite the ...
Proteome profiling in murine models of multiple sclerosis: identification of stage specific markers and culprits for tissue damage.
The identification of new biomarkers is of high interest for the prediction of the disease course and also for the identification of pathomechanisms in multiple sclerosis (MS). To specify markers of the chronic disease ...
Oral Health and nutritional status in nursing home residents—results of an explorative cross-sectional pilot study
(BioMed Central, 2017)
Abstract Background This study was performed to assess oral and nutritional status of nursing home residents in a region of Lower Saxony, Germany. The aim was to show potential associations between oral status (dentate or ...
Revisiting a historic human brain with magnetic resonance imaging - the first description of a divided central sulcus.
In 1860 and 1862, the German physiologist Wagner published two studies, in which he compared the cortical surfaces of brain specimens. This provided the first account of a rare anatomical variation - bridges across the ...
Variants of PLCXD3 are not associated with variant or sporadic Creutzfeldt-Jakob disease in a large international study
Abstract Background Human prion diseases are relentlessly progressive neurodegenerative disorders which include sporadic Creutzfeldt-Jakob disease (sCJD) and variant CJD (vCJD). Aside from variants of the prion protein ...
Is there a correlation between late re-exploration after cardiac surgery and removal of epicardial pacemaker wires?
(BioMed Central, 2017)
Abstract Background Re-exploration for bleeding accounts for increased morbidity and mortality after major cardiac operations. The use of temporary epicardial pacemaker wires is a common procedure at many departments. The ...
Evaluation of an Acute Stroke Patient with Flat Detector CT Prior to Mechanical Thrombectomy
Flat panel detectors have revolutionized tomographic imaging in the angio suite. Recent developments in hardware and software have improved soft tissue resolution and acquisition time even further, enabling soft-tissue and ...
Beneficial effect of chronic Staphylococcus aureus infection in a model of multiple sclerosis is mediated through the secretion of extracellular adherence protein
Background Bacterial infections have been assumed to worsen multiple sclerosis (MS) disease symptoms and to lead to increased neurodegeneration. However, the underlying biological mechanisms for these effects are complex ...