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4501-4510 von 4524 Publikationen
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Functional interpretation of ATAD3A variants in neuro-mitochondrial phenotypes
(BioMed Central, 2021)
Abstract
Background
ATPase family AAA-domain containing protein 3A (ATAD3A) is a nuclear-encoded mitochondrial membrane-anchored protein involved in diverse processes including ...
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Differentiation of brain metastases from small and non-small lung cancers using apparent diffusion coefficient (ADC) maps
(BioMed Central, 2021)
Background
Brain metastases are particularly common in patients with small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), with NSCLC showing a less aggressive clinical course and lower ...
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Phase I dose-escalation oncology trials with sequential multiple schedules
(BioMed Central, 2021)
Background
Conventional methods for phase I dose-escalation trials in oncology are based on a single treatment schedule only. More recently, however, multiple schedules are more frequently investigated in ...
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Discovery of novel community-relevant small proteins in a simplified human intestinal microbiome
(BioMed Central, 2021)
Background
The intestinal microbiota plays a crucial role in protecting the host from pathogenic microbes, modulating immunity and regulating metabolic processes. We studied the simplified human intestinal ...
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mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus
(BioMed Central, 2021)
Background
Tuberous sclerosis complex (TSC), a multi-system genetic disorder often associated with autism spectrum disorder (ASD), is caused by mutations of TSC1 or TSC2, which lead to constitutive ...
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Prion protein oligomers cause neuronal cytoskeletal damage in rapidly progressive Alzheimer’s disease
(BioMed Central, 2021)
Background
High-density oligomers of the prion protein (HDPs) have previously been identified in brain tissues of patients with rapidly progressive Alzheimer’s disease (rpAD). The current investigation ...
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Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host
(BioMed Central, 2021)
Background
Bacterial meningitis is a fatal disease with a mortality up to 30% and neurological sequelae in one fourth of survivors. Available vaccines do not fully protect against this lethal disease. Here, ...
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Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS
(BioMed Central, 2021)
Background
Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in septic ...
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Prognostic value of the micronucleus assay for clinical endpoints in neoadjuvant radiochemotherapy for rectal cancer
(BioMed Central, 2021)
Background
The question whether lymphocyte radiosensitivity is representative of patients’ response to radiotherapy (RT) remains unsolved. We analyzed lymphocyte cytogenetic damage in patients who were ...
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Identification of subgroup effect with an individual participant data meta-analysis of randomised controlled trials of three different types of therapist-delivered care in low back pain
(BioMed Central, 2021)
Background
Proven treatments for low back pain, at best, only provide modest overall benefits. Matching people to treatments that are likely to be most effective for them may improve clinical outcomes and ...