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Dlk1 promotes a fast motor neuron biophysical signature required for peak force execution.
Motor neurons, which relay neural commands to drive skeletal muscle movements, encompass types ranging from "slow" to "fast," whose biophysical properties govern the timing, gradation, and amplitude of muscle force. Here ...
Genetic ablation of VIAAT in glycinergic neurons causes a severe respiratory phenotype and perinatal death
Both glycinergic and GABAergic neurons require the vesicular inhibitory amino acid transporter (VIAAT) for synaptic vesicle filling. Presynaptic GABA concentrations are determined by the GABA synthesizing enzymes glutamate ...
Cytoplasmic polyadenylation element binding protein (CPEB)1 and 2 bind to the HIF-1α mRNA 3’UTR and modulate HIF-1 α protein expression
(Portland Press Limited, 2010)
The heterodimeric hypoxia-inducible factor (HIF)-1 is a transcriptional master regulator of several genes involved in mammalian oxygen homeostasis. Besides a well described regulation of the HIFα-subunit via hydroxylation-mediated ...
Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma
Loss of folate receptor-α function is associated with cerebral folate transport deficiency and childhood-onset neurodegeneration. To clarify the mechanism of cerebral folate transport at the blood–cerebrospinal fluid ...
Comparison of two self-rating instruments for medication adherence assessment in hypertension revealed insufficient psychometric properties
Objective In cases of insufficiently controlled blood pressure, it is important for practitioners to distinguish between ‘non-adherence’ and ‘non-response’ to antihypertensive drug treatment. A reliable and valid adherence ...
Bayesian inference on EMRI signals using low frequency approximations
Elevated heart-type fatty acid-binding protein levels on admission predict an adverse outcome in normotensive patients with acute pulmonary embolism.
OBJECTIVES: We assessed the predictive value of heart-type fatty acid-binding protein (H-FABP) in normotensive patients with acute pulmonary embolism (PE). BACKGROUND: Risk stratification of initially normotensive ...
Similarities between forms of sheep scrapie and Creutzfeldt-Jakob disease are encoded by distinct prion types.
Transmissible spongiform encephalopathies such as scrapie in sheep, Creutzfeldt-Jakob disease (CJD) in humans, and bovine sporadic encephalopathy in cattle are characterized by the accumulation of a misfolded protein: the ...
Ryanodin-Rezeptor-Stabilisatoren. Neue Strategie zur Behandlung von Herzrhythmusstörungen und Herzinsuffizienz
Unterschiedliche Krankheitsformen wie Arrhythmie, Herzinsuffizienz, Skelettmuskelmyopathie und Epilepsie werden neuerdings mit pathologisch gesteigerter Freisetzung („Leak“) von Ca2+ aus intrazellulären Organellen assoziiert. ...
Interleukin-2 receptor antagonists for pediatric liver transplant recipients: A systematic review and meta-analysis of controlled studies.
IL-2RA are frequently used as induction therapy in liver transplant recipients to decrease the risk of AR while allowing the reduction of concomitant immunosuppression. The exact association with the use of IL-2RA, however, ...