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Transmural Ultrasound-based Visualization of Patterns of Action Potential Wave Propagation in Cardiac Tissue

dc.contributor.authorOtani, Niels F.
dc.contributor.authorLuther, Stefan
dc.contributor.authorSingh, Rupinder
dc.contributor.authorGilmour, Robert F.
dc.date.accessioned2012-06-06T09:27:33Z
dc.date.available2012-06-06T09:27:33Z
dc.date.issued2010
dc.identifier.citationOtani, Niels F.; Luther, Stefan; Singh, Rupinder; Gilmour, Robert F. (2010): Transmural Ultrasound-based Visualization of Patterns of Action Potential Wave Propagation in Cardiac Tissue - Annals of Biomedical Engineering, Vol. 38, Nr. 10, p. 3112-3123
dc.relation.ISSN1573-9686
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/7662
dc.description.abstractThe pattern of action potential propagation during various tachyarrhythmias is strongly suspected to be composed of multiple re-entrant waves, but has never been imaged in detail deep within myocardial tissue. An understanding of the nature and dynamics of these waves is important in the development of appropriate electrical or pharmacological treatments for these pathological conditions. We propose a new imaging modality that uses ultrasound to visualize the patterns of propagation of these waves through the mechanical deformations they induce. The new method would have the distinct advantage of being able to visualize these waves deep within cardiac tissue. In this article, we describe one step that would be necessary in this imaging process—the conversion of these deformations into the action potential induced active stresses that produced them. We demonstrate that, because the active stress induced by an action potential is, to a good approximation, only nonzero along the local fiber direction, the problem in our case is actually overdetermined, allowing us to obtain a complete solution. Use of two- rather than three-dimensional displacement data, noise in these displacements, and/or errors in the measurements of the fiber orientations all produce substantial but acceptable errors in the solution. We conclude that the reconstruction of action potential-induced active stress from the deformation it causes appears possible, and that, therefore, the path is open to the development of the new imaging modality.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectAction potential imaging;Ultrasound;Cardiac muscle biomechanics;Cardiac electrophysiology
dc.titleTransmural Ultrasound-based Visualization of Patterns of Action Potential Wave Propagation in Cardiac Tissue
dc.typejournalArticle
dc.identifier.doi10.1007/s10439-010-0071-x
dc.type.versionpublishedVersion
dc.bibliographicCitation.volume38
dc.bibliographicCitation.issue10
dc.bibliographicCitation.firstPage3112
dc.bibliographicCitation.lastPage3123
dc.type.subtypejournalArticle
dc.description.statuspeerReviewed
dc.bibliographicCitation.journalAnnals of Biomedical Engineering


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