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Multiple loci linked to inversions are associated with eye size variation in species of the Drosophila virilis phylad

dc.contributor.authorReis, Micael
dc.contributor.authorWiegleb, Gordon
dc.contributor.authorClaude, Julien
dc.contributor.authorLata, Rodrigo
dc.contributor.authorHorchler, Britta
dc.contributor.authorHa, Ngoc-Thuy
dc.contributor.authorReimer, Christian
dc.contributor.authorVieira, Cristina P.
dc.contributor.authorVieira, Jorge
dc.contributor.authorPosnien, Nico
dc.date.accessioned2021-05-18T10:32:07Z
dc.date.available2021-05-18T10:32:07Z
dc.date.issued2020de
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/17820
dc.description.abstractThe size and shape of organs is tightly controlled to achieve optimal function. Natural morphological variations often represent functional adaptations to an ever-changing environment. For instance, variation in head morphology is pervasive in insects and the underlying molecular basis is starting to be revealed in the Drosophila genus for species of the melanogaster group. However, it remains unclear whether similar diversifications are governed by similar or different molecular mechanisms over longer timescales. To address this issue, we used species of the virilis phylad because they have been diverging from D. melanogaster for at least 40 million years. Our comprehensive morphological survey revealed remarkable differences in eye size and head shape among these species with D. novamexicana having the smallest eyes and southern D. americana populations having the largest eyes. We show that the genetic architecture underlying eye size variation is complex with multiple associated genetic variants located on most chromosomes. Our genome wide association study (GWAS) strongly suggests that some of the putative causative variants are associated with the presence of inversions. Indeed, northern populations of D. americana share derived inversions with D. novamexicana and they show smaller eyes compared to southern ones. Intriguingly, we observed a significant enrichment of genes involved in eye development on the 4th chromosome after intersecting chromosomal regions associated with phenotypic differences with those showing high differentiation among D. americana populations. We propose that variants associated with chromosomal inversions contribute to both intra- and interspecific variation in eye size among species of the virilis phylad.de
dc.description.sponsorshipOpen-Access-Publikationsfonds 2020
dc.language.isoengde
dc.rightsopenAccess
dc.rightsNamensnennung 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc570
dc.titleMultiple loci linked to inversions are associated with eye size variation in species of the Drosophila virilis phyladde
dc.typejournalArticlede
dc.identifier.doi10.1038/s41598-020-69719-z
dc.type.versionpublishedVersionde
dc.relation.eISSN2045-2322
dc.bibliographicCitation.volume10de
dc.bibliographicCitation.issue1de
dc.type.subtypejournalArticle
dc.description.statuspeerReviewedde
dc.bibliographicCitation.journalScientific Reportsde


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