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Multi-scale X-ray phase-contrast tomography of murine heart tissue

dc.contributor.authorReichardt, Marius
dc.contributor.authorFrohn, Jasper
dc.contributor.authorKhan, Amara
dc.contributor.authorAlves, Frauke
dc.contributor.authorSalditt, Tim
dc.date.accessioned2021-05-17T09:38:07Z
dc.date.available2021-05-17T09:38:07Z
dc.date.issued2020de
dc.relation.ISSN2156-7085de
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/17770
dc.description.abstractThe spatial organization of cardiac muscle tissue exhibits a complex structure on multiple length scales, from the sarcomeric unit to the whole organ. Here we demonstrate a multi-scale three-dimensional imaging (3d) approach with three levels of magnification, based on synchrotron X-ray phase contrast tomography. Whole mouse hearts are scanned in an undulator beam, which is first focused and then broadened by divergence. Regions-of-interest of the hearts are scanned in parallel beam as well as a biopsy by magnified cone beam geometry using a X-ray waveguide optic. Data is analyzed in terms of orientation, anisotropy and the sarcomeric periodicity via a local Fourier transformation.de
dc.description.sponsorshipOpen-Access-Publikationsfonds 2020
dc.language.isoengde
dc.rightsopenAccess
dc.subject.ddc530
dc.titleMulti-scale X-ray phase-contrast tomography of murine heart tissuede
dc.typejournalArticlede
dc.identifier.doi10.1364/BOE.386576
dc.type.versionpublishedVersionde
dc.relation.pISSN2156-7085
dc.relation.eISSN2156-7085
dc.bibliographicCitation.volume11de
dc.bibliographicCitation.issue5de
dc.bibliographicCitation.firstPage2633de
dc.bibliographicCitation.lastPage2651de
dc.type.subtypejournalArticle
dc.description.statusunKnownde
dc.bibliographicCitation.journalBiomedical Optics Expressde


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