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Sequence heterochrony led to a gain of functionality in an immature stage of the central complex: A fly–beetle insight

dc.contributor.authorFarnworth, Max S.
dc.contributor.authorEckermann, Kolja N.
dc.contributor.authorBucher, Gregor
dc.date.accessioned2020-11-16T10:34:03Z
dc.date.available2020-11-16T10:34:03Z
dc.date.issued2020de
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/17653
dc.description.abstractAnimal behavior is guided by the brain. Therefore, adaptations of brain structure and function are essential for animal survival, and each species differs in such adaptations. The brain of one individual may even differ between life stages, for instance, as adaptation to the divergent needs of larval and adult life of holometabolous insects. All such differences emerge during development, but the cellular mechanisms behind the diversification of brains between taxa and life stages remain enigmatic. In this study, we investigated holometabolous insects in which larvae differ dramatically from the adult in both behavior and morphology. As a consequence, the central complex, mainly responsible for spatial orientation, is conserved between species at the adult stage but differs between larvae and adults of one species as well as between larvae of different taxa. We used genome editing and established transgenic lines to visualize cells expressing the conserved transcription factor retinal homeobox, thereby marking homologous genetic neural lineages in both the fly Drosophila melanogaster and the beetle Tribolium castaneum. This approach allowed us for the first time to compare the development of homologous neural cells between taxa from embryo to the adult. We found complex heterochronic changes including shifts of developmental events between embryonic and pupal stages. Further, we provide, to our knowledge, the first example of sequence heterochrony in brain development, where certain developmental steps changed their position within the ontogenetic progression. We show that through this sequence heterochrony, an immature developmental stage of the central complex gains functionality in Tribolium larvae.de
dc.description.sponsorshipOpen-Access-Publikationsfonds 2020
dc.language.isoengde
dc.rightsopenAccess
dc.rightsNamensnennung 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc570
dc.titleSequence heterochrony led to a gain of functionality in an immature stage of the central complex: A fly–beetle insightde
dc.typejournalArticlede
dc.identifier.doi10.1371/journal.pbio.3000881
dc.identifier.doi10.1371/journal.pbio.3000881.g001
dc.identifier.doi10.1371/journal.pbio.3000881.g002
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dc.identifier.doi10.1371/journal.pbio.3000881.r001
dc.identifier.doi10.1371/journal.pbio.3000881.r002
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dc.identifier.doi10.1371/journal.pbio.3000881.r004
dc.identifier.doi10.1371/journal.pbio.3000881.r005
dc.identifier.doi10.1371/journal.pbio.3000881.r006
dc.type.versionpublishedVersionde
dc.relation.eISSN1545-7885
dc.bibliographicCitation.volume18de
dc.bibliographicCitation.issue10de
dc.bibliographicCitation.firstPage1de
dc.bibliographicCitation.lastPage32de
dc.type.subtypejournalArticle
dc.bibliographicCitation.articlenumbere3000881de
dc.description.statuspeerReviewedde
dc.bibliographicCitation.journalPLOS Biologyde


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