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Increased alpha-synuclein tear fluid levels in patients with Parkinson’s disease

dc.contributor.authorMaass, Fabian
dc.contributor.authorRikker, Sebastian
dc.contributor.authorDambeck, Vivian
dc.contributor.authorWarth, Carmina
dc.contributor.authorTatenhorst, Lars
dc.contributor.authorCsoti, Ilona
dc.contributor.authorSchmitz, Matthias
dc.contributor.authorZerr, Inga
dc.contributor.authorLeha, Andreas
dc.contributor.authorBähr, Mathias
dc.contributor.authorLingor, Paul
dc.date.accessioned2020-07-24T09:41:05Z
dc.date.available2020-07-24T09:41:05Z
dc.date.issued2020de
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/17459
dc.description.abstractThe objective of the study was to estimate if altered levels of alpha-synuclein can be detected in tear fluid of patients with Parkinson’s disease (PD). Therefore, tear fluid samples of 75 PD patients, 75 control subjects and 31 atypical Parkinsonian patients were collected and analyzed in triplicates using an ultra-sensitive single molecule array (SIMOA) system and applying a human alpha-synuclein immunoassay. In PD, levels of total soluble alpha-synuclein were significantly increased compared to control subjects (p = 0.03; AUC PD vs. controls 0.60). There was no difference comparing PD patients stratified by Hoehn & Yahr stages and atypical Parkinsonian syndromes stratified by tauopathies and non-PD-synucleinopathies against each other (p > 0.05). In conclusion, alpha-synuclein can be detected and quantified in tear fluid, revealing small but significant differences in total alpha-synuclein levels between PD and control subjects. Tear fluid can be collected non-invasively and risk-free, therefore presenting a promising source for further biomarker research.de
dc.description.sponsorshipOpen-Access-Publikationsfonds 2020
dc.language.isoengde
dc.rightsopenAccess
dc.rightsNamensnennung 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDiagnostic markers; Parkinson's diseasede
dc.subject.ddc610
dc.titleIncreased alpha-synuclein tear fluid levels in patients with Parkinson’s diseasede
dc.typejournalArticlede
dc.identifier.doi10.1038/s41598-020-65503-1
dc.type.versionpublishedVersionde
dc.relation.eISSN2045-2322
dc.bibliographicCitation.volume10de
dc.bibliographicCitation.issue1de
dc.bibliographicCitation.firstPage1de
dc.bibliographicCitation.lastPage5de
dc.type.subtypejournalArticle
dc.bibliographicCitation.articlenumber8507de
dc.description.statuspeerReviewedde
dc.bibliographicCitation.journalScientific Reportsde


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