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Bayesian spatial modelling of childhood cancer incidence in Switzerland using exact point data: a nationwide study during 1985–2015

dc.contributor.authorKonstantinoudis, Garyfallos
dc.contributor.authorSchuhmacher, Dominic
dc.contributor.authorAmmann, Roland A.
dc.contributor.authorDiesch, Tamara
dc.contributor.authorKuehni, Claudia E.
dc.contributor.authorSpycher, Ben D.
dc.date.accessioned2020-04-19T03:28:27Z
dc.date.available2020-04-19T03:28:27Z
dc.date.issued2020
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/17225
dc.description.abstractBackground The aetiology of most childhood cancers is largely unknown. Spatially varying environmental factors such as traffic-related air pollution, background radiation and agricultural pesticides might contribute to the development of childhood cancer. This study is the first investigation of the spatial disease mapping of childhood cancers using exact geocodes of place of residence. Methods We included 5947 children diagnosed with cancer in Switzerland during 1985–2015 at 0–15 years of age from the Swiss Childhood Cancer Registry. We modelled cancer risk using log-Gaussian Cox processes and indirect standardisation to adjust for age and year of diagnosis. We examined whether the spatial variation of risk can be explained by modelled ambient air concentration of NO2, modelled exposure to background ionising radiation, area-based socio-economic position (SEP), linguistic region, duration in years of general cancer registration in the canton or degree of urbanisation. Results For all childhood cancers combined, the posterior median relative risk (RR), compared to the national level, varied by location from 0.83 to 1.13 (min to max). Corresponding ranges were 0.96 to 1.09 for leukaemia, 0.90 to 1.13 for lymphoma, and 0.82 to 1.23 for central nervous system (CNS) tumours. The covariates considered explained 72% of the observed spatial variation for all cancers, 81% for leukaemia, 82% for lymphoma and 64% for CNS tumours. There was weak evidence of an association of CNS tumour incidence with modelled exposure to background ionising radiation (RR per SD difference 1.17; 0.98–1.40) and with SEP (1.6; 1.00–1.13). Conclusion Of the investigated diagnostic groups, childhood CNS tumours showed the largest spatial variation. The selected covariates only partially explained the observed variation of CNS tumours suggesting that other environmental factors also play a role.
dc.language.isoen
dc.publisherBioMed Central
dc.identifier.bibliographicCitationInternational Journal of Health Geographics. 2020 Apr 17;19(1):15
dc.rightsopenAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleBayesian spatial modelling of childhood cancer incidence in Switzerland using exact point data: a nationwide study during 1985–2015
dc.typejournalArticle
dc.identifier.doi10.1186/s12942-020-00211-7
dc.type.versionpublishedVersion
dc.date.updated2020-04-19T03:28:27Z
dc.rights.holderThe Author(s)
dc.bibliographicCitation.volume19
dc.bibliographicCitation.issue1
dc.type.subtypejournalArticle
dc.identifier.pmid32303231
dc.bibliographicCitation.articlenumber15
dc.bibliographicCitation.journalInternational Journal of Health Geographics


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