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GABA-Glycine Cotransmitting Neurons in the Ventrolateral Medulla: Development and Functional Relevance for Breathing

dc.contributor.authorHirrlinger, Johannes
dc.contributor.authorMarx, Grit
dc.contributor.authorBesser, Stefanie
dc.contributor.authorSicker, Marit
dc.contributor.authorKöhler, Susanne
dc.contributor.authorHirrlinger, Petra G.
dc.contributor.authorWojcik, Sonja M.
dc.contributor.authorEulenburg, Volker
dc.contributor.authorWinkler, Ulrike
dc.contributor.authorHülsmann, Swen
dc.date.accessioned2020-01-15T09:04:23Z
dc.date.available2020-01-15T09:04:23Z
dc.date.issued2019de
dc.relation.ISSN1662-5102de
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/17103
dc.description.abstractInhibitory neurons crucially contribute to shaping the breathing rhythm in the brain stem. These neurons use GABA or glycine as neurotransmitter; or co-release GABA and glycine. However, the developmental relationship between GABAergic, glycinergic and cotransmitting neurons, and the functional relevance of cotransmitting neurons has remained enigmatic. Transgenic mice expressing fluorescent markers or the split-Cre system in inhibitory neurons were developed to track the three different interneuron phenotypes. During late embryonic development, the majority of inhibitory neurons in the ventrolateral medulla are cotransmitting cells, most of which differentiate into GABAergic and glycinergic neurons around birth and around postnatal day 4, respectively. Functional inactivation of cotransmitting neurons revealed an increase of the number of respiratory pauses, the cycle-by-cycle variability, and the overall variability of breathing. In summary, the majority of cotransmitting neurons differentiate into GABAergic or glycinergic neurons within the first 2 weeks after birth and these neurons contribute to fine-tuning of the breathing pattern.de
dc.language.isoengde
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGABA; cotransmission; glycine; neuronal control of breathing; preBötzinger complex; split-Cre; ventrolateral medullade
dc.subject.ddc573
dc.subject.ddc612
dc.titleGABA-Glycine Cotransmitting Neurons in the Ventrolateral Medulla: Development and Functional Relevance for Breathingde
dc.typejournalArticlede
dc.identifier.doi10.3389/fncel.2019.00517
dc.identifier.doi10.3389/fncel.2019.00517.s001
dc.type.versionpublishedVersionde
dc.relation.eISSN1662-5102
dc.bibliographicCitation.volume13de
dc.type.subtypejournalArticle
dc.identifier.pmid31803026
dc.bibliographicCitation.articlenumber517de
dc.description.statuspeerReviewedde
dc.bibliographicCitation.journalFrontiers in Cellular Neurosciencede


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