Show simple item record

Ruthenium(II)‐Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C−H Deuteration and C−H Tritiation

dc.contributor.authorMüller, Valentin
dc.contributor.authorWeck, Remo
dc.contributor.authorDerdau, Volker
dc.contributor.authorAckermann, Lutz
dc.date.accessioned2019-12-19T10:05:50Z
dc.date.available2019-12-19T10:05:50Z
dc.date.issued2019de
dc.relation.ISSN1867-3899de
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/17034
dc.description.abstractWell-defined ruthenium(II) biscarboxylate complexes enabled selective ortho-deuteration with weakly-coordinating, synthetically useful carboxylic acid with outstanding levels of isotopic labeling. The robust nature of the catalytic system was reflected by a broad functional group tolerance in an operationallysimple manner, allowing the isotope labeling of challenging pharmaceuticals and bioactive heterocyclic motifs. The synthetic power of our method was highlighted by the selective tritium-labeling of repaglinide, an antidiabetic drug, providing access to defined tritium labeled therapeutics.de
dc.language.isoengde
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectC-H activation; hydrogen isotope exchange; ruthenium; pharmaceutical drugs; tritiumde
dc.subject.ddc540
dc.titleRuthenium(II)‐Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C−H Deuteration and C−H Tritiationde
dc.typejournalArticlede
dc.identifier.doi10.1002/cctc.201902051
dc.type.versionpublishedVersionde
dc.relation.pISSN1867-3880
dc.relation.eISSN1867-3899
dc.bibliographicCitation.issue11de
dc.bibliographicCitation.firstPage1de
dc.bibliographicCitation.lastPage6de
dc.type.subtypejournalArticle
dc.description.statuspeerReviewedde
dc.bibliographicCitation.journalChemCatChemde


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

These documents are avalilable under the license:
openAccess