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Chronic exposure to cannabinoids during adolescence causes long-lasting behavioral deficits in adult mice

dc.contributor.authorTomas-Roig, J
dc.contributor.authorBenito, E
dc.contributor.authorAgis-Balboa, RC
dc.contributor.authorPiscitelli, F
dc.contributor.authorHoyer-Fender, S
dc.contributor.authorDi Marzo, V
dc.contributor.authorHavemann-Reinecke, U
dc.date.accessioned2019-12-09T13:45:25Z
dc.date.available2019-12-09T13:45:25Z
dc.date.issued2016de
dc.relation.ISSN1355-6215de
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/16889
dc.description.abstractRegular use of marijuana during adolescence enhances the risk of long-lasting neurobiological changes in adulthood. The present study was aimed at assessing the effect of long-term administration of the synthetic cannabinoid WIN55212.2 during adolescence in young adult mice. Adolescent mice aged 5 weeks were subjected daily to the pharmacological action of WIN55212.2 for 3 weeks and were then left undisturbed in their home cage for a 5-week period and finally evaluated by behavioral testing. Mice that received the drug during adolescence showed memory impairment in the Morris water maze, as well as a dose-dependent memory impairment in fear conditioning. In addition, the administration of 3 mg/kg WIN55212.2 in adolescence increased adult hippocampal AEA levels and promoted DNA hypermethylation at the intragenic region of the intracellular signaling modulator Rgs7, which was accompanied by a lower rate of mRNA transcription of this gene, suggesting a potential causal relation. Although the concrete mechanisms underlying the behavioral observations remain to be elucidated, we demonstrate that long-term administration of 3 mg/kg of WIN during adolescence leads to increased endocannabinoid levels and altered Rgs7 expression in adulthood and establish a potential link to epigenetic changede
dc.language.isoengde
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAdolescence; CA regions; DNA methylation and Rgs7; WIN55212.2; learning and memoryde
dc.subject.ddc573
dc.subject.ddc612
dc.titleChronic exposure to cannabinoids during adolescence causes long-lasting behavioral deficits in adult micede
dc.typejournalArticlede
dc.identifier.doi10.1111/adb.12446
dc.type.versionpublishedVersionde
dc.bibliographicCitation.volume22de
dc.bibliographicCitation.issue6de
dc.bibliographicCitation.firstPage1778de
dc.bibliographicCitation.lastPage1789de
dc.type.subtypejournalArticle
dc.identifier.pmid27578457
dc.bibliographicCitation.articlenumber
dc.description.statuspeerReviewedde
dc.bibliographicCitation.journalAddiction Biologyde
dc.title.subtitleLong-lasting WIN55212.2 effect


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