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Dementia with Lewy bodies: an update and outlook

dc.contributor.authorOuteiro, Tiago Fleming
dc.contributor.authorKoss, David J.
dc.contributor.authorErskine, Daniel
dc.contributor.authorWalker, Lauren
dc.contributor.authorKurzawa-Akanbi, Marzena
dc.contributor.authorBurn, David
dc.contributor.authorDonaghy, Paul
dc.contributor.authorMorris, Christopher
dc.contributor.authorTaylor, John-Paul
dc.contributor.authorThomas, Alan
dc.contributor.authorAttems, Johannes
dc.contributor.authorMcKeith, Ian
dc.date.accessioned2019-04-15T11:41:27Z
dc.date.available2019-04-15T11:41:27Z
dc.date.issued2019de
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/16061
dc.description.abstractDementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson's disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies.de
dc.language.isoengde
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlpha-synuclein; Alzheimer’s disease; Biomarkers; Dementia; Dementia with Lewy bodiesde
dc.subject.ddc006
dc.subject.ddc573
dc.subject.ddc612
dc.titleDementia with Lewy bodies: an update and outlookde
dc.typejournalArticlede
dc.identifier.doi10.1186/s13024-019-0306-8
dc.type.versionpublishedVersionde
dc.relation.eISSN1750-1326
dc.bibliographicCitation.volume14de
dc.bibliographicCitation.issue1de
dc.type.subtypejournalArticle
dc.identifier.pmid30665447
dc.bibliographicCitation.articlenumber5de
dc.description.statuspeerReviewedde
dc.bibliographicCitation.journalMolecular Neurodegenerationde


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