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IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses

dc.contributor.authorBabaev, Olga
dc.contributor.authorCruces-Solis, Hugo
dc.contributor.authorPiletti Chatain, Carolina
dc.contributor.authorHammer, Matthieu
dc.contributor.authorWenger, Sally
dc.contributor.authorAli, Heba
dc.contributor.authorKaralis, Nikolaos
dc.contributor.authorde Hoz, Livia
dc.contributor.authorSchlüter, Oliver M.
dc.contributor.authorYanagawa, Yuchio
dc.contributor.authorEhrenreich, Hannelore
dc.contributor.authorTaschenberger, Holger
dc.contributor.authorBrose, Nils
dc.contributor.authorKrueger-Burg, Dilja
dc.date.accessioned2019-03-19T15:57:28Z
dc.date.available2019-03-19T15:57:28Z
dc.date.issued2018de
dc.relation.ISSN2041-1723de
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/15897
dc.description.abstractAbnormalities in synaptic inhibition play a critical role in psychiatric disorders, and accordingly, it is essential to understand the molecular mechanisms linking components of the inhibitory postsynapse to psychiatrically relevant neural circuits and behaviors. Here we study the role of IgSF9b, an adhesion protein that has been associated with affective disorders, in the amygdala anxiety circuitry. We show that deletion of IgSF9b normalizes anxiety-related behaviors and neural processing in mice lacking the synapse organizer Neuroligin-2 (Nlgn2), which was proposed to complex with IgSF9b. This normalization occurs through differential effects of Nlgn2 and IgSF9b at inhibitory synapses in the basal and centromedial amygdala (CeM), respectively. Moreover, deletion of IgSF9b in the CeM of adult Nlgn2 knockout mice has a prominent anxiolytic effect. Our data place IgSF9b as a key regulator of inhibition in the amygdala and indicate that IgSF9b-expressing synapses in the CeM may represent a target for anxiolytic therapies.de
dc.languageeng
dc.language.isoengde
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/213342/EU//AIMSde
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectIgSF9bde
dc.subject.ddc612
dc.subject.meshAmygdala
dc.subject.meshAnimals
dc.subject.meshAnxiety Disorders
dc.subject.meshCell Adhesion Molecules, Neuronal
dc.subject.meshMembrane Proteins
dc.subject.meshMice
dc.subject.meshMice, Knockout
dc.subject.meshNerve Tissue Proteins
dc.subject.meshRNA Interference
dc.subject.meshSynapses
dc.subject.meshSynaptic Transmission
dc.titleIgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapsesde
dc.typejournalArticlede
dc.identifier.doi10.1038/s41467-018-07762-1
dc.type.versionpublishedVersionde
dc.bibliographicCitation.volume9de
dc.bibliographicCitation.issue1de
dc.type.subtypejournalArticle
dc.identifier.pmid30573727
dc.bibliographicCitation.articlenumber5400de
dc.description.statuspeerReviewedde
dc.bibliographicCitation.journalNature Communicationsde


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