Ruthenium(II)-catalysed remote C-H alkylations as a versatile platform to meta-decorated arenes.
Li, Jie ; Korvorapun, Korkit ; De Sarkar, Suman ; Rogge, Torben ; Burns, David J. ; Warratz, Svenja ; Ackermann, Lutz
Citable Link (URL):http://resolver.sub.uni-goettingen.de/purl?gs-1/14905
The full control of positional selectivity is of prime importance in C-H activation technology. Chelation assistance served as the stimulus for the development of a plethora of ortho-selective arene functionalizations. In sharp contrast, meta-selective C-H functionalizations continue to be scarce, with all ruthenium-catalysed transformations currently requiring difficult to remove or modify nitrogen-containing heterocycles. Herein, we describe a unifying concept to access a wealth of meta-decorated arenes by a unique arene ligand effect in proximity-induced ruthenium(II) C-H activation catalysis. The transformative nature of our strategy is mirrored by providing a step-economical entry to a range of meta-substituted arenes, including ketones, acids, amines and phenols-key structural motifs in crop protection, material sciences, medicinal chemistry and pharmaceutical industries.
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