Factors determining human-to-human transmissibility of zoonotic pathogens via contact
Richard, Mathilde ; Knauf, Sascha ; Lawrence, Philip ; Mather, Alison E. ; Munster, Vincent J. ; Müller, Marcel A. ; Smith, Derek ; Kuiken, Thijs
Zitierfähiger Link (URL): http://resolver.sub.uni-goettingen.de/purl?gs-1/14430
The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and environmental levels that promote or hinder their human-to-human transmissibility via the following modes of contact transmission: skin contact, sexual contact, respiratory contact and multiple route contact. Factors common to several modes of transmission were immune evasion, high viral load, low infectious dose, crowding, promiscuity, and co-infections; other factors were specific for a pathogen or mode of contact transmission. The identification of such factors will lead to a better understanding of the requirements for human-to-human spread of pathogens, as well as improving risk assessment of newly emerging pathogens.
Gefördert von der EU
Projekt: ANTIcipating the Global Onset of Novel Epidemics (ANTIGONE)