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Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography.

dc.contributor.authorBennett, J. L.
dc.contributor.authorde Seze, J.
dc.contributor.authorLana-Peixoto, M.
dc.contributor.authorPalace, J.
dc.contributor.authorWaldman, A.
dc.contributor.authorSchippling, S.
dc.contributor.authorTenembaum, S.
dc.contributor.authorBanwell, B.
dc.contributor.authorGreenberg, B.
dc.contributor.authorLevy, M.
dc.contributor.authorFujihara, K.
dc.contributor.authorChan, K. H.
dc.contributor.authorKim, H. J.
dc.contributor.authorAsgari, N.
dc.contributor.authorSato, D. K.
dc.contributor.authorSaiz, A.
dc.contributor.authorWuerfel, J.
dc.contributor.authorZimmermann, H.
dc.contributor.authorGreen, A.
dc.contributor.authorVilloslada, P.
dc.contributor.authorPaul, F.
dc.date.accessioned2016-10-25T13:09:05Z
dc.date.available2016-10-25T13:09:05Z
dc.date.issued2015-05-01
dc.identifier.citationBennett, J L; de Seze, J; Lana-Peixoto, M; Palace, J; Waldman, A; Schippling, S; Tenembaum, S; Banwell, B; Greenberg, B; Levy, M; Fujihara, K; Chan, K H; Kim, H J; Asgari, N; Sato, D K; Saiz, A; Wuerfel, J; Zimmermann, H; Green, A; Villoslada, P; Paul, F; (2015): Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography. - Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 21, Nr. 6, p. 678-88
dc.relation.ISSN1477-0970
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/13801
dc.description.abstractNeuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients' RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.
dc.language.isoeng
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.subjectNeuromyelitis optica; optical coherence tomography; multiple sclerosis; optic neuritis; retinal nerve fiber layer; ganglion cell layer
dc.subject.meshHumans
dc.subject.meshMultiple Sclerosis
dc.subject.meshNeuromyelitis Optica
dc.subject.meshOptic Neuritis
dc.subject.meshRetinal Neurons
dc.subject.meshTomography, Optical Coherence
dc.titleNeuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography.
dc.typejournalArticle
dc.identifier.doi10.1177/1352458514567216
dc.type.versionpublishedVersion
dc.bibliographicCitation.volume21
dc.bibliographicCitation.issue6
dc.bibliographicCitation.firstPage678
dc.bibliographicCitation.lastPage688
dc.type.subtypejournalArticle
dc.identifier.pmid25662342
dc.description.statuspeerReviewed
dc.bibliographicCitation.journalMultiple sclerosis (Houndmills, Basingstoke, England)


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