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BDNF-Val66Met-polymorphism impact on cortical plasticity in schizophrenia patients: a proof-of-concept study.

dc.contributor.authorStrube, Wolfgang
dc.contributor.authorNitsche, Michael A.
dc.contributor.authorWobrock, Thomas
dc.contributor.authorBunse, Tilmann
dc.contributor.authorRein, Bettina
dc.contributor.authorHerrmann, Maximiliane
dc.contributor.authorSchmitt, Andrea
dc.contributor.authorNieratschker, Vanessa
dc.contributor.authorWitt, Stephanie H.
dc.contributor.authorRietschel, Marcella
dc.contributor.authorFalkai, Peter
dc.contributor.authorHasan, Alkomiet
dc.date.accessioned2015-05-08T08:25:26Z
dc.date.available2015-05-08T08:25:26Z
dc.date.issued2015-02-01
dc.identifier.citationStrube, Wolfgang; Nitsche, Michael A; Wobrock, Thomas; Bunse, Tilmann; Rein, Bettina; Herrmann, Maximiliane; Schmitt, Andrea; Nieratschker, Vanessa; Witt, Stephanie H; Rietschel, Marcella; Falkai, Peter; Hasan, Alkomiet (2015): BDNF-Val66Met-polymorphism impact on cortical plasticity in schizophrenia patients: a proof-of-concept study. - The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 18, Nr. 4, p.
dc.relation.ISSN1469-5111
dc.identifier.urihttp://resolver.sub.uni-goettingen.de/purl?gs-1/11781
dc.description.abstractBACKGROUND: Brain-derived neurotrophic factor (BDNF) has been shown to be a moderator of neuroplasticity. A frequent BDNF-polymorphism (Val66Met) is associated with impairments of cortical plasticity. In patients with schizophrenia, reduced neuroplastic responses following non-invasive brain stimulation have been reported consistently. Various studies have indicated a relationship between the BDNF-Val66Met-polymorphism and motor-cortical plasticity in healthy individuals, but schizophrenia patients have yet to be investigated. The aim of this proof-of-concept study was, therefore, to test the impact of the BDNF-Val66Met-polymorphism on inhibitory and facilitatory cortical plasticity in schizophrenia patients. METHODS: Cortical plasticity was investigated in 22 schizophrenia patients and 35 healthy controls using anodal and cathodal transcranial direct-current stimulation (tDCS) applied to the left primary motor cortex. Animal and human research indicates that excitability shifts following anodal and cathodal tDCS are related to molecular long-term potentiation and long-term depression. To test motor-cortical excitability before and after tDCS, well-established single- and paired-pulse transcranial magnetic stimulation protocols were applied. RESULTS: Our analysis revealed increased glutamate-mediated intracortical facilitation in met-heterozygotes compared to val-homozygotes at baseline. Following cathodal tDCS, schizophrenia met-heterozygotes had reduced gamma-amino-butyric-acid-mediated short-interval intracortical inhibition, whereas healthy met-heterozygotes displayed the opposite effect. The BDNF-Val66Met-polymorphism did not influence single-pulse motor-evoked potential amplitudes after tDCS. CONCLUSIONS: These preliminary findings support the notion of an association of the BDNF-Val66Met-polymorphism with observable alterations in plasticity following cathodal tDCS in schizophrenia patients. This indicates a complex interaction between inhibitory intracortical interneuron-networks, cortical plasticity, and the BDNF-Val66Met-polymorphism. Further replication and validation need to be dedicated to this question to confirm this relationship.
dc.description.sponsorshipOpen-Access-Publikationsfonds 2015
dc.languageeng
dc.language.isoeng
dc.rightsopenAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectirradiation; fat accumulation; liver; FAT/CD36; TNF-α; infliximab
dc.titleBDNF-Val66Met-polymorphism impact on cortical plasticity in schizophrenia patients: a proof-of-concept study.
dc.typejournalArticle
dc.identifier.doi10.1093/ijnp/pyu040
dc.type.versionpublishedVersion
dc.bibliographicCitation.volume18
dc.bibliographicCitation.issue4
dc.bibliographicCitation.firstPage4682
dc.bibliographicCitation.lastPage4697
dc.type.subtypejournalArticle
dc.identifier.pmid25612896
dc.description.statuspeerReviewed
dc.bibliographicCitation.journalThe international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)


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