Author Wirths, Oliver

• 2007 | Conference Abstract
  ​ ​A beta-induced pathology and neuron loss in the cholinergic system of the APP/PS1ki mouse model of Alzheimer's disease​
  Christensen, D. Z.; Bayer, T. & Wirths, O.​ (2007)
  Biochemical Pharmacology, 74(8) ​Symposium on Nicotinic Acetylcholine Receptors as Therapeutic Targets​, San Diego, CA.
  Oxford​: Pergamon-elsevier Science Ltd.
  ​Details  WoS 

• 2007 | Journal Article
  ​ ​Altered cholesterol metabolism in APP695-transfected neuroblastoma cells​
  Wirths, O.; Thelen, K. M.; Luetjohann, D.; Falkai, P. & Bayer, T. A.​ (2007) 
  Brain Research, 1152 pp. 209​-214​.​ DOI: https://doi.org/10.1016/j.brainres.2007.03.029 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article | 
  ​ ​Effect of copper intake on CSF parameters in patients with mild Alzheimer’s disease: a pilot phase 2 clinical trial​
  Kessler, H.; Pajonk, F.-G.; Bach, D.; Schneider-Axmann, T.; Falkai, P.; Herrmann, W. & Multhaup, G. et al.​ (2008) 
  Journal of Neural Transmission, 115(12) pp. 1651​-1659​.​ DOI: https://doi.org/10.1007/s00702-008-0136-2 
  ​Details  DOI 

• 2008 | Conference Paper | 
  ​ ​Intraneuronal beta-amyloid is a major risk factor - Novel evidence from the APP/PS1KI mouse model​
  Bayer, T. A.; Breyhan, H.; Duan, K.; Rettig, J. & Wirths, O.​ (2008)
  Neurodegenerative Diseases, 5(3-4) pp. 140​-142. ​8th International Conference on Alzheimers and Parkinsons Diseases​, Salzburg, AUSTRIA.
  Basel​: Karger. DOI: https://doi.org/10.1159/000113684 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article
  ​ ​Alzheimer's disease Molecular pathology, animal models, and current treatment​
  Bayer, T. A. & Wirths, O.​ (2008) 
  Der Nervenarzt, 79 pp. 117​-125​.​ DOI: https://doi.org/10.1007/s00115-008-2496-0 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Conference Paper
  ​ ​Review on the APP/PS1KI mouse model: intraneuronal A beta accumulation triggers axonopathy, neuron loss and working memory impairment​
  Bayer, T. A. & Wirths, O.​ (2008)
  Genes, Brain and Behavior, 7 pp. 6​-11. ​Annual Meeting of the Genes-Brain-and-Behavior-Society​, Doorwerth, NETHERLANDS.
  Oxford​: Blackwell Publishing. DOI: https://doi.org/10.1111/j.1601-183X.2007.00372.x 
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• 2008 | Journal Article
  ​ ​Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice​
  Cotel, M.-C.; Bayer, T. A. & Wirths, O.​ (2008) 
  Brain Research, 1222 pp. 207​-213​.​ DOI: https://doi.org/10.1016/j.brainres.2008.05.052 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article
  ​ ​Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease​
  Wirths, O.; Breyhan, H.; Schaefer, S.; Roth, C. & Bayer, T. A.​ (2008) 
  Neurobiology of Aging, 29(6) pp. 891​-901​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2006.12.004 
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• 2008 | Journal Article
  ​ ​Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models​
  Wirths, O. & Bayer, T. A.​ (2008) 
  Genes, Brain and Behavior, 7 pp. 1​-5​.​ DOI: https://doi.org/10.1111/j.1601-183X.2007.00373.x 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article | 
  ​ ​Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice​
  Christensen, D. Z.; Kraus, S. L.; Flohr, A.; Cotel, M.-C.; Wirths, O. & Bayer, T. A.​ (2008) 
  Acta Neuropathologica, 116(6) pp. 647​-655​.​ DOI: https://doi.org/10.1007/s00401-008-0451-6 
  ​Details  DOI  PMID  PMC  WoS 

• 2009 | Conference Abstract
  ​ ​Increasing Abeta peptide levels aggravate axonal degeneration in an Alzheimer mouse model​
  Wirths, O.; Christensen, D. Z. & Bayer, T. A.​ (2009)
  Journal of Neurochemistry, 110 pp. 38​-39. ​4th European-Society-for-Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders​, Leipzig, GERMANY.
  Malden​: Wiley-blackwell Publishing, Inc.
  ​Details  WoS 

• 2009 | Conference Abstract
  ​ ​Alzheimer's Disease pathology is not sufficient for CCR2(+) bone marrow engraftment in the CNS​
  Mildner, A.; Schlevogt, B.; Kierdorf, K.; Boettcher, C.; Kummer, M. P.; Wirths, O. & Henneka, M. et al.​ (2009)
  Acta Neuropathologica, 118(3) ​54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Dusseldorf, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2009 | Journal Article
  ​ ​The modified amyloid hypothesis of Alzheimer dementia - intraneuronal Abeta induces neurodegeneration​
  Wirths, O. & Bayer, T. A.​ (2009) 
  Neuroforum, 15(3) pp. 76​-82​.​
  ​Details  WoS 

• 2009 | Conference Abstract
  ​ ​Paradigm shift in Abeta toxicity​
  Bayer, T. A. & Wirths, O.​ (2009)
  European Neuropsychopharmacology, 19 ​22nd Congress of the European-College-of-Neuropsychopharmacology​, Istanbul, TURKEY.
  Amsterdam​: Elsevier Science Bv.
  ​Details  WoS 

• 2009 | Journal Article | 
  ​ ​Circulating immune complexes of Aβ and IgM in plasma of patients with Alzheimer’s disease​
  Marcello, A.; Wirths, O.; Schneider-Axmann, T.; Degerman-Gunnarsson, M.; Lannfelt, L. & Bayer, T.​ (2009) 
  Journal of Neural Transmission, 116(7) pp. 913​-920​.​ DOI: https://doi.org/10.1007/s00702-009-0224-y 
  ​Details  DOI 

• 2009 | Journal Article | 
  ​ ​APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy​
  Breyhan, H.; Wirths, O.; Duan, K.; Marcello, A.; Rettig, J. & Bayer, T. A.​ (2009) 
  Acta Neuropathologica, 117(6) pp. 677​-685​.​ DOI: https://doi.org/10.1007/s00401-009-0539-7 
  ​Details  DOI  PMID  PMC  WoS 

• 2009 | Journal Article
  ​ ​Formic acid is essential for immunohistochemical detection of aggregated intraneuronal A beta peptides in mouse models of Alzheimer's disease​
  Christensen, D. Z.; Bayer, T. A. & Wirths, O.​ (2009) 
  Brain Research, 1301 pp. 116​-125​.​ DOI: https://doi.org/10.1016/j.brainres.2009.09.014 
  ​Details  DOI  PMID  PMC  WoS 

• 2009 | Journal Article | 
  ​ ​Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model​
  Wirths, O.; Breyhan, H.; Cynis, H.; Schilling, S.; Demuth, H.-U. & Bayer, T. A.​ (2009) 
  Acta Neuropathologica, 118(4) pp. 487​-496​.​ DOI: https://doi.org/10.1007/s00401-009-0557-5 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Journal Article
  ​ ​Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients​
  Parlapani, E.; Schmitt, A.; Wirths, O.; Bauer, M.; Sommer, C.; Rueb, U. & Skowronek, M. H. et al.​ (2010) 
  The World Journal of Biological Psychiatry, 11(2) pp. 243​-250​.​ DOI: https://doi.org/10.3109/15622970802022376 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Journal Article | 
  ​ ​Accumulation of intraneuronal A beta correlates with ApoE4 genotype​
  Christensen, D. Z.; Schneider-Axmann, T.; Lucassen, P. J.; Bayer, T. A. & Wirths, O.​ (2010) 
  Acta Neuropathologica, 119(5) pp. 555​-566​.​ DOI: https://doi.org/10.1007/s00401-010-0666-1 
  ​Details  DOI  PMID  PMC  WoS 

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