Author Will, Cindy L.

1 to 20 of 23 Items
  • 2003 | Journal Article | Research Paper
    ​ ​Molecular Architecture of the Multiprotein Splicing Factor SF3b​
    Golas, M. M.; Sander, B.; Will, C. L.; Lührmann, R.   & Stark, H. ​ (2003) 
    Science, 300(5621) pp. 980​-984​.​ DOI: https://doi.org/10.1126/science.1084155 
    ​Details  DOI 
  • 2005 | Journal Article
    ​ ​Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy​
    Golas, M. M.; Sander, B.; Will, C. L.; Lührmann, R.   & Stark, H. ​ (2005) 
    Molecular Cell, 17(6) pp. 869​-883​.​ DOI: https://doi.org/10.1016/j.molcel.2005.02.016 
    ​Details  DOI 
  • 2006 | Journal Article
    ​ ​Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions​
    Deckert, J.; Hartmuth, K.; Boehringer, D.; Behzadnia, N.; Will, C. L.; Kastner, B. & Stark, H.  et al.​ (2006) 
    Molecular and Cellular Biology, 26(14) pp. 5528​-5543​.​ DOI: https://doi.org/10.1128/MCB.00582-06 
    ​Details  DOI 
  • 2007 | Journal Article
    ​ ​Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes​
    Behzadnia, N.; Golas, M. M.; Hartmuth, K.; Sander, B.; Kastner, B.; Deckert, J. & Dube, P. et al.​ (2007) 
    The EMBO Journal, 26(6) pp. 1737​-1748​.​ DOI: https://doi.org/10.1038/sj.emboj.7601631 
    ​Details  DOI 
  • 2012 | Journal Article
    ​ ​The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA​
    Mozaffari-Jovin, S.; Santos, K. F.; Hsiao, H.-H.; Will, C. L.; Urlaub, H.; Wahl, M. C. & Luehrmann, R.​ (2012) 
    Genes & Development, 26(21) pp. 2422​-2434​.​ DOI: https://doi.org/10.1101/gad.200949.112 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes​
    De, I.; Sessonov, S.; Hofele, R. V.; dos Santos, K.; Will, C. L.; Urlaub, H. & Luehrmann, R. et al.​ (2015) 
    Nature Structural & Molecular Biology, 22(2) pp. 138​-144​.​ DOI: https://doi.org/10.1038/nsmb.2951 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​ATP gamma S stalls splicing after B complex formation but prior to spliceosome activation​
    Agafonov, D. E.; van Santen, M.; Kastner, B.; Dube, P.; Will, C. L.; Urlaub, H. & Luehrmann, R.​ (2016) 
    RNA, 22(9) pp. 1329​-1337​.​ DOI: https://doi.org/10.1261/rna.057810.116 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations​
    Cretu, C. ; Schmitzova, J.; Ponce-Salvatierra, A.; Dybkov, O.; De laurentiis, E. I.; Sharma, K. & Will, C. L. et al.​ (2016) 
    Molecular Cell, 64(2) pp. 307​-319​.​ DOI: https://doi.org/10.1016/j.molcel.2016.08.036 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III.​
    Singh, J.; Sikand, K.; Conrad, H.; Will, C. L.; Komar, A. A. & Shukla, G. C.​ (2016) 
    Scientific reports, 6 art. 31393​.​ DOI: https://doi.org/10.1038/srep31393 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper | 
    ​ ​A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity​
    Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J. ; Agafonov, D. E.; Kastner, B. & Urlaub, H.  et al.​ (2016) 
    Nature Communications, 7 art. 11997​.​ DOI: https://doi.org/10.1038/ncomms11997 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article
    ​ ​Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation​
    Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L. & Urlaub, H.  et al.​ (2017) 
    Cell, 170(4) pp. 701​-713.e11​.​ DOI: https://doi.org/10.1016/j.cell.2017.07.011 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation​
    Sidarovich, A.; Will, C. L.; Anokhina, M. M.; Ceballos, J.; Sievers, S.; Agafonov, D. E. & Samatov, T. et al.​ (2017) 
    eLife, 6 art. e23533​.​ DOI: https://doi.org/10.7554/eLife.23533 
    ​Details  DOI  WoS 
  • 2017 | Journal Article | 
    ​ ​SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing​
    Pozzi, B.; Bragado, L.; Will, C. L.; Mammi, P.; Risso, G.; Urlaub, H. & Luehrmann, R. et al.​ (2017) 
    Nucleic Acids Research, 45(11) pp. 6729​-6745​.​ DOI: https://doi.org/10.1093/nar/gkx213 
    ​Details  DOI  WoS 
  • 2017 | Journal Article | 
    ​ ​Cryo-EM structure of a human spliceosome activated for step 2 of splicing​
    Bertram, K.; Agafonov, D. E.; Liu, W.-T.; Dybkov, O.; Will, C. L.; Hartmuth, K. & Urlaub, H.  et al.​ (2017) 
    Nature, 542(7641) pp. 318​.​ DOI: https://doi.org/10.1038/nature21079 
    ​Details  DOI  PMID  PMC  WoS 
  • 2018 | Journal Article
    ​ ​The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated B act complex​
    Bao, P.; Will, C. L.; Urlaub, H. ; Boon, K.-L.   & Lührmann, R. ​ (2018) 
    Genes & Development, 31(23-24) pp. 2416​-2429​.​ DOI: https://doi.org/10.1101/gad.308163.117 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds​
    Cretu, C. ; Agrawal, A. A.; Cook, A.; Will, C. L.; Fekkes, P.; Smith, P. G. & Lührmann, R.  et al.​ (2018) 
    Molecular Cell, 70(2) pp. 265​-273.e8​.​ DOI: https://doi.org/10.1016/j.molcel.2018.03.011 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes​
    Kastner, B.; Will, C. L.; Stark, H.   & Lührmann, R. ​ (2019) 
    Cold Spring Harbor Perspectives in Biology, 11(11) pp. a032417​.​ DOI: https://doi.org/10.1101/cshperspect.a032417 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome​
    Bertram, K.; El Ayoubi, L.; Dybkov, O.; Agafonov, D. E.; Will, C. L.; Hartmuth, K. & Urlaub, H.  et al.​ (2020) 
    Molecular Cell, 80(1) pp. 127​-139.e6​.​ DOI: https://doi.org/10.1016/j.molcel.2020.09.012 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Molecular architecture of the human 17S U2 snRNP​
    Zhang, Z.; Will, C. L.; Bertram, K.; Dybkov, O.; Hartmuth, K.; Agafonov, D. E. & Hofele, R. et al.​ (2020) 
    Nature, 583(7815) pp. 310​-313​.​ DOI: https://doi.org/10.1038/s41586-020-2344-3 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation​
    Townsend, C.; Leelaram, M. N.; Agafonov, D. E.; Dybkov, O.; Will, C. L.; Bertram, K. & Urlaub, H. et al.​ (2020) 
    Science, 370(6523) art. eabc3753​.​ DOI: https://doi.org/10.1126/science.abc3753 
    ​Details  DOI 

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