Author Weggen, Sascha

• 2012 | Conference Abstract
  ​ ​Effects of subchronic inhalation exposure to diesel engine exhaust in the 5xFAD mouse model of Alzheimer's Disease​
  Hullmann, M.; Albrecht, C.; van Berlo, D.; Gerlofs-Nijland, M. E.; Hillmann, A.; Boere, A. & Fokkens, P. et al.​ (2012)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 385 ​78th Annual Congress of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology (DGPT)​, Dresden, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2012 | Journal Article
  ​ ​No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease​
  Hillmann, A.; Hahn, S.; Schilling, S.; Hoffmann, T.; Demuth, H.-U.; Bulic, B. & Schneider-Axmann, T. et al.​ (2012) 
  Neurobiology of Aging, 33(4) art. 833.e39​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2011.08.006 
  ​Details  DOI  PMID  PMC  WoS 

• 2015 | Journal Article
  ​ ​Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease​
  Richard, B. C. ; Kurdakova, A.; Baches, S.; Bayer, T. A.; Weggen, S. & Wirths, O.​ (2015) 
  Journal of Alzheimer s Disease, 45(4) pp. 1223​-1236​.​ DOI: https://doi.org/10.3233/JAD-143120 
  ​Details  DOI  PMID  PMC  WoS 

• 2015 | Journal Article
  ​ ​Neprilysin Deficiency Alters the Neuropathological and Behavioral Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease​
  Huettenrauch, M.; Baches, S.; Gerth, J.; Bayer, T. A.; Weggen, S. & Wirths, O. ​ (2015) 
  Journal of Alzheimer s Disease, 44(4) pp. 1291​-1302​.​ DOI: https://doi.org/10.3233/JAD-142463 
  ​Details  DOI  PMID  PMC  WoS 

• 2015 | Journal Article | 
  ​ ​Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X​
  Antonios, G.; Borgers, H.; Richard, B. C. ; Brauss, A.; Meissner, J.; Weggen, S. & Pena, V. et al.​ (2015) 
  Scientific Reports, 5 art. 17338​.​ DOI: https://doi.org/10.1038/srep17338 
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• 2016 | Journal Article
  ​ ​Limited Effects of Prolonged Environmental Enrichment on the Pathology of 5XFAD Mice​
  Hüttenrauch, M. ; Walter, S.; Kaufmann, M.; Weggen, S. & Wirths, O. ​ (2016) 
  Molecular Neurobiology, 54(8) pp. 6542​-6555​.​ DOI: https://doi.org/10.1007/s12035-016-0167-x 
  ​Details  DOI 

• 2016 | Journal Article | 
  ​ ​Endothelial LRP1 transports amyloid-beta(1-42) across the blood-brain barrier​
  Storck, S. E.; Meister, S.; Nahrath, J.; Meissner, J. N.; Schubert, N.; Di Spiezio, A. & Baches, S. et al.​ (2016) 
  Journal of Clinical Investigation, 126(1) pp. 123​-136​.​ DOI: https://doi.org/10.1172/JCI81108 
  ​Details  DOI  PMID  PMC  WoS 

• 2017 | Journal Article | 
  ​ ​N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models​
  Wirths, O. ; Walter, S.; Kraus, I. ; Klafki, H. W. ; Stazi, M.; Oberstein, T. J. & Ghiso, J. et al.​ (2017) 
  Alzheimer's Research & Therapy, 9(1) art. 80​.​ DOI: https://doi.org/10.1186/s13195-017-0309-z 
  ​Details  DOI 

• 2018 | Journal Article
  ​ ​The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease​
  Walter, S.; Jumpertz, T.; Hüttenrauch, M. ; Ogorek, I.; Gerber, H.; Storck, S. E. & Zampar, S. et al.​ (2018) 
  Acta Neuropathologica, 137(2) pp. 239​-257​.​ DOI: https://doi.org/10.1007/s00401-018-1929-5 
  ​Details  DOI 

• 2018 | Journal Article | 
  ​ ​Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia​
  Hüttenrauch, M.; Ogorek, I.; Klafki, H.; Otto, M.; Stadelmann, C. ; Weggen, S. & Wiltfang, J. et al.​ (2018) 
  Acta Neuropathologica Communications, 6(1) art. 108​.​ DOI: https://doi.org/10.1186/s40478-018-0612-3 
  ​Details  DOI 

• 2019 | Book Chapter | 
  ​ ​N-Terminally Truncated Aβ Peptide Variants in Alzheimer’s Disease​
  Wirths, O. ; Zampar, S.& Weggen, S.​ (2019)
  In: Alzheimer’s Disease pp. 107​-122.  DOI: https://doi.org/10.15586/alzheimersdisease.2019.ch7 
  ​Details  DOI 

• 2021 | Journal Article | Research Paper | 
  ​ ​Evaluation of cerebrospinal fluid glycoprotein NMB (GPNMB) as a potential biomarker for Alzheimer’s disease​
  Aichholzer, F.; Klafki, H.-W.; Ogorek, I.; Vogelgsang, J.; Wiltfang, J.; Scherbaum, N. & Weggen, S. et al.​ (2021) 
  Alzheimer's Research & Therapy, 13(1) art. 94​.​ DOI: https://doi.org/10.1186/s13195-021-00828-1 
  ​Details  DOI 

• 2021 | Journal Article | 
  ​ ​Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis​
  Stazi, M.; Lehmann, S.; Sakib, M. S.; Pena-Centeno, T.; Büschgens, L.; Fischer, A. & Weggen, S. et al.​ (2021) 
  Cellular and Molecular Life Sciences, 79(1) art. 55​.​ DOI: https://doi.org/10.1007/s00018-021-04062-8 
  ​Details  DOI 

• 2023 | Journal Article | 
  ​ ​Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice​
  Bader, A. S.; Gnädig, M.-U.; Fricke, M.; Büschgens, L.; Berger, L. J.; Weggen, S. & Klafki, H.-W. et al.​ (2023) 
  Life, 13(4) pp. 1053​.​ DOI: https://doi.org/10.3390/life13041053 
  ​Details  DOI 

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