Author Spieth, Lena

• 2017 | Journal Article | 
  ​ ​Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model​
  Berghoff, S. A.; Düking, T.; Spieth, L.; Winchenbach, J.; Stumpf, S. K.; Gerndt, N. & Kusch, K. et al.​ (2017) 
  Acta Neuropathologica Communications, 5(1).​ DOI: https://doi.org/10.1186/s40478-017-0497-6 
  ​Details  DOI 

• 2019 | Journal Article | Erratum | 
  ​ ​Correction to: Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease​
  Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A.; Spieth, L.; Düking, T.; Schneider, L. V. & Schlaphoff, L. et al.​ (2019) 
  Acta Neuropathologica, 138(4) pp. 673​-674​.​ DOI: https://doi.org/10.1007/s00401-019-02064-2 
  ​Details  DOI  PMID  PMC 

• 2019 | Journal Article | 
  ​ ​Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease​
  Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A. ; Spieth, L.; Düking, T.; Schneider, L. V. & Schlaphoff, L. et al.​ (2019) 
  Acta Neuropathologica, 138(1) pp. 147​-161​.​ DOI: https://doi.org/10.1007/s00401-019-01985-2 
  ​Details  DOI  PMID  PMC 

• 2020 | Journal Article | Research Paper
  ​ ​Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis​
  Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L. ; Schlaphoff, L.; Depp, C. & Düking, T. et al.​ (2020) 
  Nature Neuroscience, 24(1) pp. 47​-60​.​ DOI: https://doi.org/10.1038/s41593-020-00757-6 
  ​Details  DOI  PMID  PMC 

• 2021 | Journal Article
  ​ ​Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice​
  Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L.; Depp, C.; Sasmita, A. O. & Vasileva, M. H. et al.​ (2021) 
  Cell Reports, 37(4) art. S2211124721013590​.​ DOI: https://doi.org/10.1016/j.celrep.2021.109889 
  ​Details  DOI 

• 2021 | Journal Article
  ​ ​Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport​
  Spieth, L.; Berghoff, S. A; Stumpf, S. K; Winchenbach, J.; Michaelis, T.; Watanabe, T. & Gerndt, N. et al.​ (2021) 
  Neuro-Oncology Advances, 3(1) art. vdab140​.​ DOI: https://doi.org/10.1093/noajnl/vdab140 
  ​Details  DOI 

• 2021 | Journal Article | Research Paper | 
  ​ ​NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: a mild encephalitis model with neuropsychiatric relevance​
  Arinrad, S.; Wilke, J. B. H.; Seelbach, A.; Doeren, J.; Hindermann, M.; Butt, U. J. & Steixner-Kumar, A. A. et al.​ (2021) 
  Molecular Psychiatry,.​ DOI: https://doi.org/10.1038/s41380-021-01392-8 
  ​Details  DOI  PMID  PMC 

• 2022 | Journal Article
  ​ ​Local cholesterol metabolism orchestrates remyelination​
  Berghoff, S. A.; Spieth, L. & Saher, G.​ (2022) 
  Trends in Neurosciences, 45(4) pp. 272​-283​.​ DOI: https://doi.org/10.1016/j.tins.2022.01.001 
  ​Details  DOI 

• 2022 | Journal Article | 
  ​ ​Ketogenic diet uncovers differential metabolic plasticity of brain cells​
  Düking, T.; Spieth, L.; Berghoff, S. A.; Piepkorn, L.; Schmidke, A. M.; Mitkovski, M. & Kannaiyan, N. et al.​ (2022) 
  Science Advances, 8(37) art. eabo7639​.​ DOI: https://doi.org/10.1126/sciadv.abo7639 
  ​Details  DOI  PMID  PMC 

• 2023 | Preprint
  ​ ​Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer’s disease​
  Sasmita, A. O.; Depp, C.; Nazarenko, T.; Sun, T.; Siems, S. B.; Yu, X.& Boehler, C. et al.​ (2023). DOI: https://doi.org/10.1101/2023.12.11.570514 
  ​Details  DOI 

• 2023 | Journal Article | 
  ​ ​Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease​
  Depp, C.; Sun, T.; Sasmita, A. O.; Spieth, L.; Berghoff, S. A.; Nazarenko, T. & Overhoff, K. et al.​ (2023) 
  Nature, 618(7964) pp. 349​-357​.​ DOI: https://doi.org/10.1038/s41586-023-06120-6 
  ​Details  DOI  PMID  PMC 

Researcher

Sort

Items per Page