Author Saher, Gesine
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2005 | Journal Article
High cholesterol level is essential for myelin membrane growth
Saher, G.; Brügger, B.; Lappe-Siefke, C.; Möbius, W. ; Tozawa, R.-i.; Wehr, M. C & Wieland, F. et al. (2005)
Nature Neuroscience, 8(4) pp. 468-475. DOI: https://doi.org/10.1038/nn1426
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2007 | Journal Article |
Survival of adult neurons lacking cholesterol synthesis in vivo
Fünfschilling, U.; Saher, G.; Xiao, L.; Möbius, W. & Nave, K.-A. (2007)
BMC Neuroscience, 8(1) pp. 1-9. DOI: https://doi.org/10.1186/1471-2202-8-1
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2009 | Conference Abstract
High-Level Expression of the Proteolipids Plp and M6b is Sufficient to Induce Oligodendroglial Process Outgrowth in Vitro and Required for Normal Myelination in Vivo
de Monasterio-Schrader, P. ; Werner, H. B. ; Kraemer-Albers, E.-M.; Strenzke, N. ; Saher, G.; Möbius, W. & Tenzer, S. et al. (2009)
Glia, 57(13) pp. S115-S116. 9th European Meeting on Glial Cells in Health and Disease, Paris, FRANCE.
Hoboken: Wiley-liss.
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2011 | Journal Article
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity
Kassmann, C. M.; Quintes, S.; Rietdorf, J.; Möbius, W. ; Sereda, M. W.; Nientiedt, T. & Saher, G. et al. (2011)
FEBS Letters, 585(14) pp. 2205-2211. DOI: https://doi.org/10.1016/j.febslet.2011.05.032
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2012 | Journal Article |
Critical Time Window of Neuronal Cholesterol Synthesis during Neurite Outgrowth
Fuenfschilling, U.; Jockusch, W. J.; Sivakumar, N.; Möbius, W. ; Corthals, K.; Li, S. & Quintes, S. et al. (2012)
Journal of Neuroscience, 32(22) pp. 7632-7645. DOI: https://doi.org/10.1523/JNEUROSCI.1352-11.2012
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2012 | Journal Article
Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet
Saher, G.; Rudolphi, F.; Corthals, K.; Ruhwedel, T.; Schmidt, K.-F.; Loewel, S. & Dibaj, P. et al. (2012)
Nature Medicine, 18(7) pp. 1130-+. DOI: https://doi.org/10.1038/nm.2833
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2013 | Journal Article | Research Paper
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system
Werner, H. B. ; Kraemer-Albers, E.-M.; Strenzke, N. ; Saher, G.; Tenzer, S.; Ohno-Iwashita, Y. & Monasterio-Schrader, P. de et al. (2013)
Glia, 61(4) pp. 567-586. DOI: https://doi.org/10.1002/glia.22456
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2014 | Journal Article
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity
Hammer, C. ; Stepniak, B. ; Schneider, A. ; Papiol, S. ; Tantra, M. ; Begemann, M. & Sirén, A.-L. et al. (2014)
Molecular Psychiatry, 19(10) pp. 1143-1149. DOI: https://doi.org/10.1038/mp.2013.110
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2016 | Journal Article
Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice
Winchenbach, J.; Düking, T.; Berghoff, S. A.; Stumpf, S. K.; Hülsmann, S. ; Nave, K.-A. & Saher, G. (2016)
F1000Research, 5 pp. 2934. DOI: https://doi.org/10.12688/f1000research.10509.1
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2017 | Journal Article |
Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model
Berghoff, S. A.; Düking, T.; Spieth, L.; Winchenbach, J.; Stumpf, S. K.; Gerndt, N. & Kusch, K. et al. (2017)
Acta Neuropathologica Communications, 5(1). DOI: https://doi.org/10.1186/s40478-017-0497-6
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2017 | Journal Article |
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain
Berghoff, S. A.; Gerndt, N.; Winchenbach, J.; Stumpf, S. K.; Hosang, L.; Odoardi, F. & Ruhwedel, T. et al. (2017)
Nature Communications, 8 art. 14241. DOI: https://doi.org/10.1038/ncomms14241
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2018 | Journal Article |
Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model
Pan, H.; Oliveira, B. ; Saher, G.; Dere, E. ; Tapken, D.; Mitjans, M. & Seidel, J. et al. (2018)
Molecular Psychiatry, 24(10) pp. 1489-1501. DOI: https://doi.org/10.1038/s41380-017-0011-3
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2019 | Journal Article |
Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease
Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A. ; Spieth, L.; Düking, T.; Schneider, L. V. & Schlaphoff, L. et al. (2019)
Acta Neuropathologica, 138(1) pp. 147-161. DOI: https://doi.org/10.1007/s00401-019-01985-2
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2019 | Journal Article | Erratum |
Correction to: Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease
Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A.; Spieth, L.; Düking, T.; Schneider, L. V. & Schlaphoff, L. et al. (2019)
Acta Neuropathologica, 138(4) pp. 673-674. DOI: https://doi.org/10.1007/s00401-019-02064-2
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2020 | Journal Article | Research Paper
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L. ; Schlaphoff, L.; Depp, C. & Düking, T. et al. (2020)
Nature Neuroscience, 24(1) pp. 47-60. DOI: https://doi.org/10.1038/s41593-020-00757-6
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2021 | Journal Article
Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice
Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L.; Depp, C.; Sasmita, A. O. & Vasileva, M. H. et al. (2021)
Cell Reports, 37(4) art. S2211124721013590. DOI: https://doi.org/10.1016/j.celrep.2021.109889
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2021 | Journal Article
Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport
Spieth, L.; Berghoff, S. A; Stumpf, S. K; Winchenbach, J.; Michaelis, T.; Watanabe, T. & Gerndt, N. et al. (2021)
Neuro-Oncology Advances, 3(1) art. vdab140. DOI: https://doi.org/10.1093/noajnl/vdab140
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2022 | Journal Article
Local cholesterol metabolism orchestrates remyelination
Berghoff, S. A.; Spieth, L. & Saher, G. (2022)
Trends in Neurosciences, 45(4) pp. 272-283. DOI: https://doi.org/10.1016/j.tins.2022.01.001
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2022 | Journal Article |
Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner
Lutomska, L. M.; Miok, V.; Krahmer, N.; González García, I.; Gruber, T.; Le Thuc, O. & Murat, C. D. et al. (2022)
Glia, art. glia.24237. DOI: https://doi.org/10.1002/glia.24237
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2022 | Journal Article |
Ketogenic diet uncovers differential metabolic plasticity of brain cells
Düking, T.; Spieth, L.; Berghoff, S. A.; Piepkorn, L.; Schmidke, A. M.; Mitkovski, M. & Kannaiyan, N. et al. (2022)
Science Advances, 8(37) art. eabo7639. DOI: https://doi.org/10.1126/sciadv.abo7639
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