Author Najafova, Zeynab

• 2014 | Journal Article | 
  ​ ​Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription​
  Nagarajan, S.; Hossan, T. ; Alawi, M.; Najafova, Z.; Indenbirken, D.; Bedi, U. & Taipaleenmaeki, H. et al.​ (2014) 
  Cell Reports, 8(2) pp. 459​-468​.​ DOI: https://doi.org/10.1016/j.celrep.2014.06.016 
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• 2016 | Journal Article
  ​ ​MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53​
  Wienken, M.; Dickmanns, A.; Nemajerova, A.; Kramer, D.; Najafova, Z.; Weiss, M. & Karpiuk, O. et al.​ (2016) 
  Molecular Cell, 61(1) pp. 68​-83​.​ DOI: https://doi.org/10.1016/j.molcel.2015.12.008 
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• 2016 | Journal Article | 
  ​ ​Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity​
  Sriraman, A.; Radovanovic, M.; Wienken, M.; Najafova, Z.; Li, Y. & Dobbelstein, M. ​ (2016) 
  Oncotarget, 7(22) pp. 31623​-31638​.​ DOI: https://doi.org/10.18632/oncotarget.9302 
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• 2017 | Journal Article | 
  ​ ​Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4-and MYC-dependent manner​
  Mishra, V. K.; Wegwitz, F.; Kosinsky, R. L.; Sen, M. ; Baumgartner, R.; Wulff, T. & Siveke, J. T. et al.​ (2017) 
  Nucleic Acids Research, 45(11) pp. 6334​-6349​.​ DOI: https://doi.org/10.1093/nar/gkx212 
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• 2017 | Journal Article | 
  ​ ​RNF40 regulates gene expression in an epigenetic context-dependent manner​
  Xie, W.; Nagarajan, S.; Baumgart, S. J.; Kosinsky, R. L.; Najafova, Z.; Kari, V. & Hennion, M. et al.​ (2017) 
  Genome Biology, 18 art. 32​.​ DOI: https://doi.org/10.1186/s13059-017-1159-5 
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• 2017 | Journal Article | 
  ​ ​BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire​
  Najafova, Z.; Tirado-Magallanes, R.; Subramaniam, M.; Hossan, T.; Schmidt, G.; Nagarajan, S. & Baumgart, S. J. et al.​ (2017) 
  Nucleic Acids Research, 45(1) pp. 127​-141​.​ DOI: https://doi.org/10.1093/nar/gkw826 
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• 2017 | Journal Article | 
  ​ ​BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells​
  Nagarajan, S.; Bedi, U.; Budida, A. ; Hamdan, F. H. ; Mishra, V. K.; Najafova, Z. & Xie, W. et al.​ (2017) 
  Nucleic Acids Research, 45(6) pp. 3130​-3145​.​ DOI: https://doi.org/10.1093/nar/gkw1276 
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• 2018 | Journal Article | 
  ​ ​CDK4 inhibition diminishes p53 activation by MDM2 antagonists​
  Sriraman, A.; Dickmanns, A.; Najafova, Z.; Johnsen, S. A. & Dobbelstein, M. ​ (2018) 
  Cell Death & Disease, 9(9) art. 918​.​ DOI: https://doi.org/10.1038/s41419-018-0968-0 
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• 2019 | Journal Article | 
  ​ ​The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness​
  Kari, V.; Raul, S. K; Henck, J. M; Kitz, J.; Kramer, F.; Kosinsky, R. L & Übelmesser, N. et al.​ (2019) 
  Clinical Epigenetics, 11(1) art. 4​.​ DOI: https://doi.org/10.1186/s13148-018-0601-1 
  ​Details  DOI 

• 2021 | Journal Article | 
  ​ ​Telomerase and Pluripotency Factors Jointly Regulate Stemness in Pancreatic Cancer Stem Cells​
  Walter, K.; Rodriguez-Aznar, E.; Ferreira, M. S. V.; Frappart, P.-O.; Dittrich, T.; Tiwary, K. & Meessen, S. et al.​ (2021) 
  Cancers, 13(13) pp. 3145​.​ DOI: https://doi.org/10.3390/cancers13133145 
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• 2021 | Journal Article | Research Paper
  ​ ​STIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer​
  Kutschat, A. P.; Hamdan, F. H.; Wang, X.; Wixom, A. Q.; Najafova, Z.; Gibhardt, C. S. & Kopp, W. et al.​ (2021) 
  Cancer Research, art. canres.2874.2020​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-20-2874 
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• 2023 | Journal Article
  ​ ​Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma​
  Wang, X.; Kutschat, A. P.; Aggrey-Fynn, J.; Hamdan, F. H.; Graham, R. P.; Wixom, A. Q. & Souto, Y. et al.​ (2023) 
  Molecular Cancer Research, pp. OF1​-OF11​.​ DOI: https://doi.org/10.1158/1541-7786.MCR-22-0916 
  ​Details  DOI 

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