Author Krewer, Birgit
-
2006 | Journal Article
Investigation of reactivity and selectivity of DNA-alkylating duocarmycin analogues by high-resolution mass spectrometry
Tietze, L. F.; Krewer, B.; Frauendorf, H.; Major, F. & Schuberth, I. (2006)
Angewandte Chemie International Edition, 45(39) pp. 6570-6574. DOI: https://doi.org/10.1002/anie.200600935
Details DOI PMID PMC WoS
-
2007 | Journal Article
Selective treatment of cancer: Synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC-1065 and the duocarmycins
Tietze, L. F.; Major, F.; Schuberth, I.; Spiegl, D. A.; Krewer, B.; Maksimenka, K. & Bringmann, G. et al. (2007)
Chemistry - A European Journal, 13(16) pp. 4396-4409. DOI: https://doi.org/10.1002/chem.200700113
Details DOI PMID PMC WoS
-
2008 | Journal Article |
Synthesis and biological evaluation of a novel pentagastrin-toxin conjugate designed for a targeted prodrug monotherapy of cancer
Tietze, L. F.; Panknin, O.; Krewer, B.; Major, F. & Schuberth, I. (2008)
International Journal of Molecular Sciences, 9(5) pp. 821-837. DOI: https://doi.org/10.3390/ijms9050821
Details DOI PMID PMC WoS
-
2008 | Journal Article
Synthesis of a novel pentagastrin-drug conjugate for a targeted tumor therapy
Tietze, L. F.; Panknin, O.; Major, F. & Krewer, B. (2008)
Chemistry - A European Journal, 14(9) pp. 2811-2818. DOI: https://doi.org/10.1002/chem.200701521
Details DOI PMID PMC WoS
-
2008 | Journal Article
Asymmetric Synthesis and Biological Evaluation of Glycosidic Prodrugs for a Selective Cancer Therapy
Tietze, L. F.; von Hof, J. M.; Krewer, B.; Mueller, M.; Major, F.; Schuster, H. J. & Schuberth, I. et al. (2008)
ChemMedChem, 3(12) pp. 1946-1955. DOI: https://doi.org/10.1002/cmdc.200800250
Details DOI PMID PMC WoS
-
2009 | Review
Novel Analogues of CC-1065 and the Duocarmycins for the Use in Targeted Tumour Therapies
Tietze, L. F.& Krewer, B. (2009)
Anti-Cancer Agents in Medicinal Chemistry, 9(3) pp. 304-325.
Bentham Science Publ Ltd.
Details PMID PMC WoS
-
2009 | Review
Antibody-Directed Enzyme Prodrug Therapy: A Promising Approach for a Selective Treatment of Cancer Based on Prodrugs and Monoclonal Antibodies
Tietze, L. F.& Krewer, B. (2009)
Chemical Biology & Drug Design, 74(3) pp. 205-211.
Wiley-blackwell Publishing, Inc. DOI: https://doi.org/10.1111/j.1747-0285.2009.00856.x
Details DOI PMID PMC WoS
-
2009 | Journal Article
CD-Spectroscopy As a Powerful Tool for Investigating the Mode of Action of Unmodified Drugs in Live Cells
Tietze, L. F.; Krewer, B.; Major, F. & Schuberth, I. (2009)
Journal of the American Chemical Society, 131(36) pp. 13031-13036. DOI: https://doi.org/10.1021/ja902767f
Details DOI PMID PMC WoS
-
2009 | Journal Article
Probing the mechanism of action of potential anticancer agents at a molecular level using electrospray ionisation Fourier transform ion cyclotron resonance mass spectrometry
Tietze, L. F.; Krewer, B. & Frauendorf, H. (2009)
European Journal of Mass Spectrometry, 15(5) pp. 661-672. DOI: https://doi.org/10.1255/ejms.1021
Details DOI PMID PMC WoS
-
2009 | Conference Paper |
Investigation of the transformations of a novel anti-cancer agent combining HPLC, HPLC-MS and direct ESI-HRMS analyses
Tietze, L. F.; Krewer, B. & Frauendorf, H. (2009)
Analytical and Bioanalytical Chemistry, 395(2) pp. 437-448. 27th International Symposium on Chromatography, Munster, GERMANY.
Heidelberg: Springer. DOI: https://doi.org/10.1007/s00216-009-2963-x
Details DOI PMID PMC WoS
-
2009 | Journal Article
Synthesis and Biological Studies of Different Duocarmycin Based Glycosidic Prodrugs for Their Use in the Antibody-Directed Enzyme Prodrug Therapy
Tietze, L. F.; Schuster, H. J.; Krewer, B. & Schuberth, I. (2009)
Journal of Medicinal Chemistry, 52(2) pp. 537-543. DOI: https://doi.org/10.1021/jm8009102
Details DOI PMID PMC WoS
-
2009 | Journal Article |
Determination of the Biological Activity and Structure Activity Relationships of Drugs Based on the Highly Cytotoxic Duocarmycins and CC-1065
Tietze, L. F.; Krewer, B.; von Hof, J. M.; Frauendorf, H. & Schuberth, I. (2009)
Toxins, 1(2) pp. 134-150. DOI: https://doi.org/10.3390/toxins1020134
Details DOI PMID PMC WoS
-
2010 | Journal Article
Synthesis of Fluorescence-Labelled Glycosidic Prodrugs Based on the Cytotoxic Antibiotic Duocarmycin
Tietze, L. F.; Behrendt, F.; Major, F.; Krewer, B. & von Hof, J. M. (2010)
European Journal of Organic Chemistry,(36) pp. 6909-6921. DOI: https://doi.org/10.1002/ejoc.201000966
Details DOI WoS
-
2010 | Journal Article
Synthesis of the first spacer containing prodrug of a duocarmycin analogue and determination of its biological activity
Schuster, H. J.; Krewer, B.; von Hof, J. M.; Schmuck, K.; Schuberth, I.; Alves, F. & Tietze, L. F. (2010)
Organic & Biomolecular Chemistry, 8(8) pp. 1833-1842. DOI: https://doi.org/10.1039/b925070k
Details DOI PMID PMC WoS
-
2010 | Journal Article
Glycosidic Prodrugs of Highly Potent Bifunctional Duocarmycin Derivatives for Selective Treatment of Cancer
Tietze, L. F. ; von Hof, J. M.; Mueller, M.; Krewer, B. & Schuberth, I. (2010)
Angewandte Chemie International Edition, 49(40) pp. 7336-7339. DOI: https://doi.org/10.1002/anie.201002502
Details DOI PMID PMC WoS
-
2011 | Journal Article |
Enhanced tumor therapy using vaccinia virus strain GLV-1h68 in combination with a beta-galactosidase-activatable prodrug seco-analog of duocarmycin SA
Seubert, C. M.; Stritzker, J.; Hess, M.; Donat, U.; Sturm, J. B.; Chen, N. & von Hof, J. M. et al. (2011)
Cancer Gene Therapy, 18(1) pp. 42-52. DOI: https://doi.org/10.1038/cgt.2010.49
Details DOI PMID PMC WoS