Author Knepel, Willhart

• 2000 | Review
  ​ ​Heterodimeric Pbx-Prep1 homeodomain protein binding to the glucagon gene restricting transcription in a cell type-dependent manner​
  Herzig, S.; Fuzesi, L.& Knepel, W.​ (2000)
  Journal of Biological Chemistry, 275​(36) pp. 27989​-27999​.​
  Amer Soc Biochemistry Molecular Biology Inc.
  ​Details  PMID  PMC  WoS 

• 2000 | Journal Article
  ​ ​Insulin responsiveness of the glucagon gene conferred by interactions between proximal promoter and more distal enhancer-like elements involving the paired-domain transcription factor Pax6​
  Grzeskowiak, R.; Amin, J.; Oetjen, E. & Knepel, W.​ (2000) 
  Journal of Biological Chemistry, 275(39) pp. 30037​-30045​.​ DOI: https://doi.org/10.1074/jbc.M000984200 
  ​Details  DOI  PMID  PMC  WoS 

• 2001 | Conference Abstract
  ​ ​PPAR gamma-mediated inhibition of glucagon gene transcription by the oral antidiabetic agents thiazolidinediones​
  Schinner, S.; Dellas, C.; Heinlein, C.; Chang, C. & Knepel, W.​ (2001)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 363(4) 
  New york​: Springer.
  ​Details  WoS 

• 2001 | Conference Abstract
  ​ ​Effect of the dual leucine zipper bearing kinase on membrane-depolarization-stimulated CRE/CREB-dependent transcription​
  Oetjen, E.; Lechleiter, A.; Blume, R.; Nihalani, D.; Holzman, L. & Knepel, W.​ (2001)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 363(4) 
  New york​: Springer.
  ​Details  WoS 

• 2002 | Conference Abstract
  ​ ​Effect of antidepressant drugs and psychosocial stress on cAMP response element dependent reporter gene expression in the brain of transgenic mice​
  Alejel, T.; Beimesche, S.; Cierny, I.; Krause, D. & Knepel, W.​ (2002)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 365 
  New york​: Springer.
  ​Details  WoS 

• 2002 | Conference Abstract
  ​ ​Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in a pancreatic beta-cell line and in primary mature pancreatic islets of transgenic mice​
  Oetjen, E.; Grapentin, D.; Baun, D.; Blume, R.; Krause, D.; Beimesche, S. & Cierny, I. et al.​ (2002)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 365 
  New york​: Springer.
  ​Details  WoS 

• 2002 | Journal Article
  ​ ​Repression of glucagon gene transcription by peroxisome proliferator-activated receptor gamma through inhibition of Pax6 transcriptional activity​
  Schinner, S.; Dellas, C.; Schröder, M.; Heinlein, C. A.; Chang, C. S.; Fischer, J. & Knepel, W.​ (2002) 
  Journal of Biological Chemistry, 277(3) pp. 1941​-1948​.​ DOI: https://doi.org/10.1074/jbc.M109718200 
  ​Details  DOI  PMID  PMC  WoS 

• 2003 | Conference Abstract
  ​ ​Regulation of glucagon gene transcription by insulin: Role of glycogen synthase kinase 3​
  Dimopoulos, N. & Knepel, W.​ (2003)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 367 ​44th Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie/20th Gesellschaft-fur-Umwelt-Mutationsforschung​, MAINZ, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2003 | Conference Abstract
  ​ ​The thiazolidinedione-binding nuclear receptor PPAR gamma mediates inhibition of glucagon gene transcription as a heterodimer with​
  Lepler, K.; Schinner, S. & Knepel, W.​ (2003)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 367 ​44th Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie/20th Gesellschaft-fur-Umwelt-Mutationsforschung​, MAINZ, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2003 | Conference Abstract
  ​ ​The map kinase kinase kinase 1 inhibits CREB transcriptional activity stimulated by cyclic amp and membrane depolarization​
  Oetjen, E.; Grandke, G.; Blume, R. & Knepel, W.​ (2003)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 367 ​44th Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie/20th Gesellschaft-fur-Umwelt-Mutationsforschung​, MAINZ, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2003 | Journal Article
  ​ ​Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB​
  Oetjen, E.; Grapentin, D.; Blume, R.; Seeger, M.; Krause, D.; Eggers, A. & Knepel, W.​ (2003) 
  Naunyn-Schmiedeberg s Archives of Pharmacology, 367(3) pp. 227​-236​.​ DOI: https://doi.org/10.1007/s00210-003-0694-7 
  ​Details  DOI  PMID  PMC  WoS 

• 2003 | Journal Article
  ​ ​Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus in primary, mature islets of transgenic mice​
  Oetjen, E.; Baun, D.; Beimesche, S.; Krause, D.; Cierny, I.; Blume, R. & Dickel, C. et al.​ (2003) 
  Molecular Pharmacology, 63(6) pp. 1289​-1295​.​ DOI: https://doi.org/10.1124/mol.63.6.1289 
  ​Details  DOI  PMID  PMC  WoS 

• 2004 | Conference Abstract
  ​ ​The map kinase kinase kinase I enhances the transcriptional activity of PAX6 and PPAR gamma​
  Oetjen, E.; Theuner, Y.; Blume, R. & Knepel, W.​ (2004)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 369 ​45th Spring Meeting of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology​, Mainz, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2004 | Conference Abstract
  ​ ​The map kinase kinase kinase 1 does not diminish cylic AMP-induced phosphorylation of CREB on Ser-119​
  Schlag, C.; Oetjen, E.; Blume, R. & Knepel, W.​ (2004)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 369 ​45th Spring Meeting of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology​, Mainz, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2005 | Conference Abstract
  ​ ​Effect of rosiglitazone and ppar gamma on human insulin gene transcription​
  Kratzner, R.; Schinner, S.; Schlenczek, S.; Dickel, C. & Knepel, W.​ (2005)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 371 , Mainz, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2005 | Conference Abstract
  ​ ​Chronic but not acute treatment with lithium salts reduces CRE/CREB-directed gene transcription in transgenic reporter gene mice​
  Boer, U.; Cierny, I.; Krouse, D. & Knepel, W.​ (2005)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 371 ​46th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie​, Mainz, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2005 | Conference Abstract
  ​ ​Inhibition of the inter-action between CREB and its coactivator cbp by MEKK1 as revealed by fret​
  Oetjen, E.; Schlag, C.; Mayr, B. M.; Blume, R. & Knepel, W.​ (2005)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 371 ​46th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie​, Mainz, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2005 | Conference Abstract
  ​ ​Molecular mechanisms of insulin resistance​
  Gonzalez-Aguitre, M.; Boer, U. & Knepel, W.​ (2005)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 371 ​46th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie​, Mainz, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2005 | Journal Article
  ​ ​Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans​
  Sharma, S. K.; Leinemann, U.; Ratke, R.; Oetjen, E.; Blume, R.; Dickel, C. & Knepel, W.​ (2005) 
  Biochemical Journal, 389 pp. 831​-841​.​ DOI: https://doi.org/10.1042/BJ20050334 
  ​Details  DOI  PMID  PMC  WoS 

• 2005 | Journal Article
  ​ ​Protein kinase B activity is sufficient to mimic the effect of insulin on glucagon gene transcription​
  Schinner, S.; Barthel, A.; Dellas, C.; Grzeskowiak, R.; Sharma, S. K.; Oetjen, E. & Blume, R. et al.​ (2005) 
  Journal of Biological Chemistry, 280(8) pp. 7369​-7376​.​ DOI: https://doi.org/10.1074/jbc.M408560200 
  ​Details  DOI  PMID  PMC  WoS 

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