Author Kügler, Sebastian

• 2009 | Journal Article | 
  ​ ​AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice.​
  Jaworski, T.; Dewachter, I.; Lechat, B.; Croes, S.; Termont, A.; Demedts, D. & Borghgraef, P. et al.​ (2009) 
  PloS one, 4(10) art. e7280​.​ DOI: https://doi.org/10.1371/journal.pone.0007280 
  ​Details  DOI  PMID  PMC 

• 2010 | Journal Article | 
  ​ ​Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease.​
  Jaworski, T.; Kügler, S. & Van Leuven, F.​ (2010) 
  International journal of Alzheimer's disease, 2010.​ DOI: https://doi.org/10.4061/2010/573138 
  ​Details  DOI  PMID  PMC 

• 2014 | Journal Article | 
  ​ ​Pre-existing immunity to adeno-associated virus (AAV)2 limits transgene expression following intracerebral AAV2-based gene delivery in a 6-hydroxydopamine model of Parkinson's disease.​
  Janelidze, S.; Nordström, U.; Kügler, S. & Brundin, P.​ (2014) 
  The journal of gene medicine, 16(9-10) pp. 300​-308​.​ DOI: https://doi.org/10.1002/jgm.2779 
  ​Details  DOI  PMID  PMC 

• 2016 | Book Chapter
  ​ ​Tissue-Specific Promoters in the CNS​
  Kügler, S.​ (2016)
  In:​Manfredsson, Fredric P.​ (Ed.), Methods in Molecular Biology Gene Therapy for Neurological Disorders pp. 81​-91. ​New York, NY: ​Springer New York. DOI: https://doi.org/10.1007/978-1-4939-3271-9_6 
  ​Details  DOI 

• 2018 | Journal Article | 
  ​ ​Pathophysiological Consequences of Neuronal α-Synuclein Overexpression: Impacts on Ion Homeostasis, Stress Signaling, Mitochondrial Integrity, and Electrical Activity​
  Tolö, J.; Taschenberger, G.; Leite, K.; Stahlberg, M. A.; Spehlbrink, G.; Kues, J. & Munari, F. et al.​ (2018) 
  Frontiers in Molecular Neuroscience, 11 art. 49​.​ DOI: https://doi.org/10.3389/fnmol.2018.00049 
  ​Details  DOI 

• 2018 | Book Chapter
  ​ ​Pharmacologically Controlled Neurotrophic Factor Gene Therapy for Parkinson’s Disease​
  Kügler, S.​ (2018)
  In: Gene Therapy in Neurological Disorders pp. 177​-193. ​Elsevier. DOI: https://doi.org/10.1016/B978-0-12-809813-4.00008-9 
  ​Details  DOI 

• 2019 | Book Chapter
  ​ ​MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain​
  Noroozian, Z.; Xhima, K.; Huang, Y.; Kaspar, B. K.; Kügler, S.; Hynynen, K.& Aubert, I.​ (2019)
  In:​Castle, Michael J.​ (Ed.), Adeno-Associated Virus Vectors : Design and Delivery pp. 177​-197. ​New York, NY: ​Springer New York. DOI: https://doi.org/10.1007/978-1-4939-9139-6_10 
  ​Details  DOI 

• 2019 | Journal Article | Research Paper
  ​ ​Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein​
  Pinho, R.; Paiva, I.; Jercic, K. G.; Fonseca-Ornelas, L.; Gerhardt, E.; Fahlbusch, C. & Garcia-Esparcia, P. et al.​ (2019) 
  Human Molecular Genetics, 28(1) pp. 31​-50​.​ DOI: https://doi.org/10.1093/hmg/ddy326 
  ​Details  DOI  PMID  PMC 

• 2019 | Journal Article
  ​ ​β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration​
  Lodygin, D.; Hermann, M.; Schweingruber, N.; Flügel-Koch, C.; Watanabe, T.; Schlosser, C. & Merlini, A. et al.​ (2019) 
  Nature, 566(7745) pp. 503​-508​.​ DOI: https://doi.org/10.1038/s41586-019-0964-2 
  ​Details  DOI  PMID  PMC 

• 2019 | Journal Article | Research Paper | 
  ​ ​Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O2 Consumption and ROS Release​
  Can, K.; Menzfeld, C.; Rinne, L.; Rehling, P. ; Kügler, S.; Golubiani, G. & Dudek, J. et al.​ (2019) 
  Frontiers in Physiology, 10 art. 479​.​ DOI: https://doi.org/10.3389/fphys.2019.00479 
  ​Details  DOI  PMID  PMC 

• 2019 | Journal Article | 
  ​ ​Publisher Correction: β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration​
  Lodygin, D.; Hermann, M.; Schweingruber, N.; Flügel-Koch, C.; Watanabe, T.; Schlosser, C. & Merlini, A. et al.​ (2019) 
  Nature, 567(7749) pp. E15​-E15​.​ DOI: https://doi.org/10.1038/s41586-019-1047-0 
  ​Details  DOI  PMID  PMC 

• 2021 | Journal Article
  ​ ​Dementia with Lewy bodies—associated ß-synuclein mutations V70M and P123H cause mutation-specific neuropathological lesions​
  Psol, M.; Darvas, S. G.; Leite, K.; Mahajani, S. U; Bähr, M.   & Kügler, S.​ (2021) 
  Human Molecular Genetics, 30(3-4) pp. 247​-264​.​ DOI: https://doi.org/10.1093/hmg/ddab036 
  ​Details  DOI 

• 2021 | Journal Article
  ​ ​Optimized pharmacological control over the AAV-Gene-Switch vector for regulable gene therapy​
  Cheng, S.; van Gaalen, M. M.; Bähr, M. ; Garea-Rodriguez, E. & Kügler, S.​ (2021) 
  Molecular Therapy - Methods & Clinical Development, 23 pp. 1​-10​.​ DOI: https://doi.org/10.1016/j.omtm.2021.07.007 
  ​Details  DOI 

• 2021 | Journal Article | 
  ​ ​Generation and Breeding of EGFP-Transgenic Marmoset Monkeys: Cell Chimerism and Implications for Disease Modeling​
  Drummer, C.; Vogt, E.-J.; Heistermann, M.; Roshani, B.; Becker, T.; Mätz-Rensing, K. & Kues, W. A. et al.​ (2021) 
  Cells, 10(3) pp. 505​.​ DOI: https://doi.org/10.3390/cells10030505 
  ​Details  DOI 

• 2022 | Journal Article | Research Paper
  ​ ​The relevance of synuclein autoantibodies as a biomarker for Parkinson's disease​
  Garg, P.; Maass, F.; Sundaram, S. M.; Mollenhauer, B.; Mahajani, S.; van Riesen, C. & Kügler, S. et al.​ (2022) 
  Molecular and Cellular Neuroscience, 121 art. 103746​.​ DOI: https://doi.org/10.1016/j.mcn.2022.103746 
  ​Details  DOI  PMID  PMC 

• 2023 | Journal Article | 
  ​ ​S-SCAM is essential for synapse formation​
  Wittenmayer, N.; Petkova-Tuffy, A.; Borgmeyer, M.; Lee, C.; Becker, J.; Böning, A. & Kügler, S. et al.​ (2023) 
  Frontiers in Cellular Neuroscience, 17.​ DOI: https://doi.org/10.3389/fncel.2023.1182493 
  ​Details  DOI 

• 2024 | Journal Article | 
  ​ ​Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons​
  Garg, P.; Würtz, F.; Hobbie, F.; Buttgereit, K.; Leite, K.; Aich, A. & Rehling, P. et al.​ (2024) 
  Journal of Neuroinflammation, 21(1) art. 62​.​ DOI: https://doi.org/10.1186/s12974-024-03050-6 
  ​Details  DOI  PMID  PMC 

• 2024 | Journal Article
  ​ ​Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants​
  Knauer, C.; Haltern, H.; Schoger, E.; Kügler, S.; Roos, L.; Zelarayán, L. C. & Hasenfuss, G. et al.​ (2024) 
  Molecular Therapy - Nucleic Acids, 35(1) art. 102123​.​ DOI: https://doi.org/10.1016/j.omtn.2024.102123 
  ​Details  DOI  PMID  PMC 

Researcher

Sort

Items per Page