Author Gerhardt, Ellen

• 2005 | Journal Article
  ​ ​FasL (CD95L/APO-1L) resistance of neurons mediated by phosphatidylinositol 3-kinase-Akt protein kinase B-dependent expression of lifeguard/neuronal membrane protein 35​
  Beier, C. P.; Wischhusen, J.; Gleichmann, M.; Gerhardt, E.; Pekanovic, A.; Krueger, A. & Taylor, V. et al.​ (2005) 
  Journal of Neuroscience, 25(29) pp. 6765​-6774​.​ DOI: https://doi.org/10.1523/JNEUROSCI.1700-05.2005 
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• 2008 | Journal Article
  ​ ​Emergence of brain-derived neurotrophic factor-induced postsynaptic potentiation of NMDA currents during the postnatal maturation of the Kolliker-Fuse nucleus of rat​
  Kron, M.; Reuter, J.; Gerhardt, E.; Manzke, T.; Zhang, W. & Dutschmann, M.​ (2008) 
  The Journal of Physiology, 586(9) pp. 2331​-2343​.​ DOI: https://doi.org/10.1113/jphysiol.2007.148916 
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• 2009 | Journal Article
  ​ ​Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors​
  Krenz, A.; Falkenburger, B. H.; Gerhardt, E.; Drinkut, A. & Schulz, J. B.​ (2009) 
  Journal of Neurochemistry, 108(1) pp. 139​-146​.​ DOI: https://doi.org/10.1111/j.1471-4159.2008.05755.x 
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• 2010 | Journal Article | 
  ​ ​Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis​
  Linker, R. A.; Lee, D.-H.; Demir, S.; Wiese, S.; Kruse, N.; Siglienti, I. & Gerhardt, E. et al.​ (2010) 
  Brain, 133 pp. 2248​-2263​.​ DOI: https://doi.org/10.1093/brain/awq179 
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• 2011 | Journal Article
  ​ ​Fas/CD95 Regulatory Protein Faim2 Is Neuroprotective after Transient Brain Ischemia​
  Reich, A.; Spering, C. ; Gertz, K.; Harms, C.; Gerhardt, E.; Kronenberg, G. & Nave, K. A. et al.​ (2011) 
  Journal of Neuroscience, 31(1) pp. 225​-233​.​ DOI: https://doi.org/10.1523/JNEUROSCI.2188-10.2011 
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• 2011 | Journal Article | 
  ​ ​Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice​
  Gerhardt, E.; Graeber, S.; Szego, E. M.; Moisoi, N.; Martins, L. M.; Outeiro, T. F.   & Kermer, P.​ (2011) 
  PLoS ONE, 6(12) art. e28855​.​ DOI: https://doi.org/10.1371/journal.pone.0028855 
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• 2011 | Conference Paper
  ​ ​Dopamine-depletion and increased alpha-synuclein load induce degeneration of cortical cholinergic fibers in mice​
  Szego, E. M.; Gerhardt, E.; Outeiro, T. F.   & Kermer, P.​ (2011)
  Journal of the Neurological Sciences, 310(1-2) pp. 90​-95. , Barcelona, SPAIN.
  Amsterdam​: Elsevier Science Bv. DOI: https://doi.org/10.1016/j.jns.2011.06.048 
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• 2012 | Journal Article | 
  ​ ​The Mitochondrial Chaperone Protein TRAP1 Mitigates alpha-Synuclein Toxicity​
  Butler, E. K.; Voigt, A.; Lutz, A. K.; Toegel, J. P.; Gerhardt, E.; Karsten, P. & Falkenburger, B. H. et al.​ (2012) 
  PLoS Genetics, 8(2) art. e1002488​.​ DOI: https://doi.org/10.1371/journal.pgen.1002488 
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• 2012 | Journal Article
  ​ ​A30P alpha-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice​
  Szego, E. M.; Gerhardt, E.; Kermer, P. & Schulz, J. B.​ (2012) 
  Neurobiology of Disease, 45(1) pp. 591​-600​.​ DOI: https://doi.org/10.1016/j.nbd.2011.09.017 
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• 2015 | Journal Article
  ​ ​Mutant huntingtin alters Tau phosphorylation and subcellular distribution​
  Blum, D.; Herrera, F.; Francelle, L. ; Mendes, T.; Basquin, M.; Obriot, H. & Demeyer, D. et al.​ (2015) 
  Human Molecular Genetics, 24(1) pp. 76​-85​.​ DOI: https://doi.org/10.1093/hmg/ddu421 
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• 2015 | Journal Article | 
  ​ ​Elevated alpha-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells​
  Oliveira, L. M. A.; Falomir-Lockhart, L. J.; Botelho, M. G.; Lin, K.-H.; Wales, P.; Koch, J. C. & Gerhardt, E. et al.​ (2015) 
  Cell Death and Disease, 6 art. e1994​.​ DOI: https://doi.org/10.1038/cddis.2015.318 
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• 2015 | Journal Article
  ​ ​HMGB1 and RAGE in skeletal muscle inflammation: Implications for protein accumulation in inclusion body myositis​
  Muth, I. E.; Zschuentzsch, J.; Kleinschnitz, K.; Wrede, A.; Gerhardt, E.; Balcarek, P. & Schreiber-Katz, O. et al.​ (2015) 
  Experimental Neurology, 271 pp. 189​-197​.​ DOI: https://doi.org/10.1016/j.expneurol.2015.05.023 
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• 2016 | Journal Article | 
  ​ ​Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles​
  Pinho, R.; Guedes, L. C.; Soreq, L.; Lobo, P. P.; Mestre, T.; Coelho, M. & Rosa, M. M. et al.​ (2016) 
  PLoS ONE, 11(6) art. e0157852​.​ DOI: https://doi.org/10.1371/journal.pone.0157852 
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• 2016 | Journal Article
  ​ ​Environmental and genetic factors support the dissociation between alpha-synuclein aggregation and toxicity​
  Villar-Pique, A.; da Fonseca, T. L.; Sant'Anna, R.; Szegoe, E. M.; Fonseca-Ornelas, L.; Pinho, R. & Carija, A. et al.​ (2016) 
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(42) pp. E6506​-E6515​.​ DOI: https://doi.org/10.1073/pnas.1606791113 
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• 2017 | Journal Article
  ​ ​Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway​
  Szegő, É. M.; Gerhardt, E. & Outeiro, T. F. ​ (2017) 
  Neurobiology of Aging, 56 pp. 7​-16​.​ DOI: https://doi.org/10.1016/j.neurobiolaging.2017.04.001 
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• 2017 | Journal Article | 
  ​ ​The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease​
  de Oliveira, R. M.; Miranda, H. V.; Francelle, L.; Pinho, R.; Szegoe, E. M.; Martinho, R. & Munari, F. et al.​ (2017) 
  PLoS Biology, 15(3) art. e2000374​.​ DOI: https://doi.org/10.1371/journal.pbio.2000374 
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• 2018 | Journal Article | Research Paper | 
  ​ ​Membrane binding, internalization, and sorting of alpha-synuclein in the cell​
  Masaracchia, C.; Hnida, M.; Gerhardt, E.; Lopes da Fonseca, T.; Villar-Pique, A.; Branco, T. & Stahlberg, M. A. et al.​ (2018) 
  Acta Neuropathologica Communications, 6(1) art. 79​.​ DOI: https://doi.org/10.1186/s40478-018-0578-1 
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• 2019 | Journal Article | Research Paper
  ​ ​Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein​
  Pinho, R.; Paiva, I.; Jercic, K. G.; Fonseca-Ornelas, L.; Gerhardt, E.; Fahlbusch, C. & Garcia-Esparcia, P. et al.​ (2019) 
  Human Molecular Genetics, 28(1) pp. 31​-50​.​ DOI: https://doi.org/10.1093/hmg/ddy326 
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• 2019 | Journal Article | Research Paper | 
  ​ ​Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies​
  Szegő, É. M.; Dominguez-Meijide, A.; Gerhardt, E.; König, A.; Koss, D. J.; Li, W. & Pinho, R. et al.​ (2019) 
  Cell Reports, 28(1) pp. 65.e6​-77.e6​.​ DOI: https://doi.org/10.1016/j.celrep.2019.06.009 
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• 2021 | Preprint
  ​ ​Monitoring Alpha-Synuclein – Tau Interactions In Vitro and In Vivo Using Bimolecular Fluorescence Complementation​
  Torres-Garcia, L.; Domingues, J. M.; Brandi, E.; Haikal, C.; Brás, I. C.; Gerhardt, E.& Li, W. et al.​ (2021). DOI: https://doi.org/10.21203/rs.3.rs-960446/v1 
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