Author Bastians, Holger

• 2010 | Journal Article | 
  ​ ​The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells​
  Stolz, A.; Ertych, N.; Kienitz, A.; Vogel, C.; Schneider, V.; Fritz, B. & Jacob, R. et al.​ (2010) 
  Nature Cell Biology, 12(5) pp. 492​-499​.​ DOI: https://doi.org/10.1038/ncb2051 
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• 2011 | Journal Article
  ​ ​Therapeutic targeting of the mitotic spindle checkpoint through nanoparticle-mediated siRNA delivery inhibits tumor growth in vivo​
  Kaestner, P.; Aigner, A. & Bastians, H.​ (2011) 
  Cancer Letters, 304(2) pp. 128​-136​.​ DOI: https://doi.org/10.1016/j.canlet.2011.02.014 
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• 2011 | Journal Article
  ​ ​Tumor Suppressor CHK2: Regulator of DNA Damage Response and Mediator of Chromosomal Stability​
  Stolz, A.; Ertych, N. & Bastians, H.​ (2011) 
  Clinical Cancer Research, 17(3) pp. 401​-405​.​ DOI: https://doi.org/10.1158/1078-0432.CCR-10-1215 
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• 2013 | Journal Article | Letter Note
  ​ ​Therapeutic S and G(2) checkpoint override causes centromere fragmentation in mitosis​
  Stolz, A. & Bastians, H.​ (2013) 
  Cell Cycle, 12(12) pp. 1826​-+​.​ DOI: https://doi.org/10.4161/cc.25175 
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• 2014 | Journal Article
  ​ ​Microtubule plus tips: A dynamic route to chromosomal instability​
  Stolz, A.; Ertych, N. & Bastians, H.​ (2014) 
  Molecular & Cellular Oncology, 2(2) pp. e960768​.​ DOI: https://doi.org/10.4161/23723548.2014.960768 
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• 2014 | Journal Article
  ​ ​Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells​
  Ertych, N.; Stolz, A.; Stenzinger, A.; Weichert, W.; Kaulfuss, S.; Burfeind, P. & Aigner, A. et al.​ (2014) 
  Nature Cell Biology, 16(8) pp. 779​-U274​.​ DOI: https://doi.org/10.1038/ncb2994 
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• 2015 | Book Chapter
  ​ ​Causes of Chromosomal Instability​
  Bastians, H.​ (2015)
  In:​Ghadimi, B. Michael; Ried, Thomas​ (Eds.), Chromosomal Instability in Cancer Cells pp. 95​-113. ​Cham: ​Springer International Publishing. DOI: https://doi.org/10.1007/978-3-319-20291-4_5 
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• 2015 | Journal Article
  ​ ​Wnt‐mediated protein stabilization ensures proper mitotic microtubule assembly and chromosome segregation​
  Stolz, A.; Neufeld, K.; Ertych, N. & Bastians, H.​ (2015) 
  EMBO Reports, 16(4) pp. 490​-499​.​ DOI: https://doi.org/10.15252/embr.201439410 
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• 2015 | Journal Article
  ​ ​A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation​
  Stolz, A.; Ertych, N. & Bastians, H.​ (2015) 
  Cell Cycle, 14(6) pp. 827​-837​.​ DOI: https://doi.org/10.1080/15384101.2014.1000693 
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• 2015 | Journal Article
  ​ ​Fresh WNT into the regulation of mitosis​
  Stolz, A. & Bastians, H.​ (2015) 
  Cell Cycle, 14(16) pp. 2566​-2570​.​ DOI: https://doi.org/10.1080/15384101.2015.1064569 
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• 2016 | Journal Article | 
  ​ ​Identification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression data​
  Schrader, A.; Meyer, K.; Walther, N.; Stolz, A.; Feist, M. ; Hand, E. & von Bonin, F. et al.​ (2016) 
  Oncotarget, 7(30) pp. 47061​-47081​.​ DOI: https://doi.org/10.18632/oncotarget.9219 
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• 2016 | Journal Article
  ​ ​CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly​
  Ertych, N.; Stolz, A.; Valerius, O.; Braus, G. H. & Bastians, H.​ (2016) 
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(7) pp. 1817​-1822​.​ DOI: https://doi.org/10.1073/pnas.1525129113 
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• 2017 | Journal Article | 
  ​ ​Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells​
  Kramer, D.; Stark, N. ; Schulz-Heddergott, R.; Erytch, N.; Edmunds, S.; Rossmann, L.   & Bastians, H. et al.​ (2017) 
  Cell Death and Differentiation, 24(2) pp. 300​-316​.​ DOI: https://doi.org/10.1038/cdd.2016.124 
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• 2018 | Book Chapter
  ​ ​A Cell-Based Assay for Mitotic Spindle Orientation​
  Glaubke, E.& Bastians, H.​ (2018)
  In:​Wagner, Bridget​ (Ed.), Methods in Molecular Biology Phenotypic Screening pp. 67​-75. ​New York, NY: ​Springer New York. DOI: https://doi.org/10.1007/978-1-4939-7847-2_5 
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• 2019 | Journal Article | 
  ​ ​The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness​
  Kari, V.; Raul, S. K; Henck, J. M; Kitz, J.; Kramer, F.; Kosinsky, R. L & Übelmesser, N. et al.​ (2019) 
  Clinical Epigenetics, 11(1) art. 4​.​ DOI: https://doi.org/10.1186/s13148-018-0601-1 
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• 2021 | Journal Article | 
  ​ ​DNA-Replikationsstress, Mitose und genomische Instabilität​
  Konrath, A.; Schmidt, A.-K. & Bastians, H.​ (2021) 
  BIOspektrum, 27(1) pp. 10​-13​.​ DOI: https://doi.org/10.1007/s12268-021-1525-5 
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• 2022 | Journal Article
  ​ ​Increased replication origin firing links replication stress to whole chromosomal instability in human cancer​
  Böhly, N.; Schmidt, A.-K.; Zhang, X.; Slusarenko, B. O.; Hennecke, M.; Kschischo, M. & Bastians, H.​ (2022) 
  Cell Reports, 41(11) art. 111836​.​ DOI: https://doi.org/10.1016/j.celrep.2022.111836 
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• 2022 | Journal Article
  ​ ​Increased Microtubule Growth Triggered by Microvesicle-mediated Paracrine Signaling is Required for Melanoma Cancer Cell Invasion​
  Pudelko, K.; Wieland, A.; Hennecke, M.; Räschle, M. & Bastians, H.​ (2022) 
  Cancer Research Communications, 2(5) pp. 366​-379​.​ DOI: https://doi.org/10.1158/2767-9764.CRC-22-0010 
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