Author Werner, Hauke B.

• 2007 | Conference Abstract
  ​ ​Inactivation of peroxisome function in oligodendrocytes - a mouse phenocopy of human adrenoleukodystrophy​
  Kassmann, C. M.; Lappe-Siefke, C.; Baes, M.; Mildner, A.; Natt, O.; Werner, H. B. & Prinz, M. R. et al.​ (2007)
  NEURON GLIA BIOLOGY, 2 
  New york​: Cambridge Univ Press.
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• 2007 | Journal Article
  ​ ​Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes​
  Kassmann, C. M.; Lappe-Siefke, C.; Baes, M.; Bruegger, B.; Mildner, A.; Werner, H. B. & Natt, O. et al.​ (2007) 
  Nature Genetics, 39(8) pp. 969​-976​.​ DOI: https://doi.org/10.1038/ng2070 
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• 2007 | Journal Article | Research Paper
  ​ ​Proteolipid protein is required for transport of sirtuin 2 into CNS myelin​
  Werner, H. B.; Kuhlmann, K.; Shen, S.; Uecker, M.; Schardt, A.; Dimova, K. & Orfaniotou, F. et al.​ (2007) 
  The Journal of Neuroscience, 27(29) pp. 7717​-7730​.​ DOI: https://doi.org/10.1523/JNEUROSCI.1254-07.2007 
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• 2008 | Journal Article
  ​ ​Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum​
  Cooper, B.; Werner, H. B. & Flügge, G.​ (2008) 
  Brain Research, 1197 pp. 1​-12​.​ DOI: https://doi.org/10.1016/j.brainres.2007.11.066 
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• 2009 | Journal Article
  ​ ​Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1​
  Edgar, J. M.; McLaughlin, M.; Werner, H. B.; McCulloch, M. C.; Barrie, J. A.; Brown, A. & Faichney, A. B. et al.​ (2009) 
  Glia, 57(16) pp. 1815​-1824​.​ DOI: https://doi.org/10.1002/glia.20893 
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• 2009 | Journal Article
  ​ ​Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection​
  Möbius, W. ; Patzig, J.; Nave, K.-A. & Werner, H. B.​ (2009) 
  Neuron Glia Biology, 4(2) pp. 111​-127​.​ DOI: https://doi.org/10.1017/S1740925X0900009X 
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• 2009 | Conference Abstract
  ​ ​THERAPEUTIC ATTEMPTS IN A MOUSE MODEL FOR PELIZAEUS-MERZBACHER DISEASE​
  Werner, H. B.; Epplen, D. B.; Prukop, T.; Stassart, R. M.; Dhaunchak, A. S.; Nave, K. A. & Sereda, M. W.​ (2009)
  Glia, 57(13) ​9th European Meeting on Glial Cells in Health and Disease​, Paris, FRANCE.
  Hoboken​: Wiley-blackwell.
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• 2009 | Journal Article
  ​ ​The SNARE Protein SNAP-29 Interacts With the GTPase Rab3A: Implications for Membrane Trafficking in Myelinating Glia​
  Schardt, A.; Brinkmann, B. G.; Mitkovski, M.; Sereda, M. W.; Werner, H. B. & Nave, K.-A.​ (2009) 
  Journal of Neuroscience Research, 87(15) pp. 3465​-3479​.​ DOI: https://doi.org/10.1002/jnr.22005 
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• 2009 | Journal Article
  ​ ​Phosphatidylinositol 4,5-Bisphosphate-Dependent Interaction of Myelin Basic Protein with the Plasma Membrane in Oligodendroglial Cells and Its Rapid Perturbation by Elevated Calcium​
  Nawaz, S.; Kippert, A.; Saab, A. S.; Werner, H. B.; Lang, T.; Nave, K.-A. & Simons, M.​ (2009) 
  Journal of Neuroscience, 29(15) pp. 4794​-4807​.​ DOI: https://doi.org/10.1523/JNEUROSCI.3955-08.2009 
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• 2009 | Journal Article | Research Paper
  ​ ​Myelin proteomics: molecular anatomy of an insulating sheath​
  Jahn, O. ; Tenzer, S. & Werner, H. B.​ (2009) 
  Molecular Neurobiology, 40(1) pp. 55​-72​.​ DOI: https://doi.org/10.1007/s12035-009-8071-2 
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• 2010 | Journal Article | Research Paper
  ​ ​Myelin matters: proteomic insights into white matter disorders​
  Werner, H. B. & Jahn, O. ​ (2010) 
  Expert Review of Proteomics, 7(2) pp. 159​-164​.​ DOI: https://doi.org/10.1586/epr.09.105 
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• 2012 | Journal Article | Research Paper
  ​ ​Systematic approaches to central nervous system myelin​
  de Monasterio-Schrader, P.; Jahn, O. ; Tenzer, S.; Wichert, S. P.; Patzig, J. & Werner, H. B.​ (2012) 
  Cellular and Molecular Life Sciences, 69(17) pp. 2879​-2894​.​ DOI: https://doi.org/10.1007/s00018-012-0958-9 
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• 2013 | Journal Article
  ​ ​Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2​
  de Monasterio-Schrader, P.; Patzig, J.; Möbius, W. ; Barrette, B.; Wagner, T. L.; Kusch, K. & Edgar, J. M. et al.​ (2013) 
  Glia, 61(11) pp. 1832​-1847​.​ DOI: https://doi.org/10.1002/glia.22561 
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• 2013 | Journal Article | 
  ​ ​Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model (vol 89, pg 389, 2011)​
  Brendel, C.; Belakhov, V.; Werner, H. B.; Wegener, E.; Gärtner, J. ; Nudelman, I. & Baasov, T. et al.​ (2013) 
  Journal of Molecular Medicine, 91(6).​ DOI: https://doi.org/10.1007/s00109-013-1029-x 
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• 2013 | Journal Article | Research Paper
  ​ ​Molecular evolution of myelin basic protein, an abundant structural myelin component​
  Nawaz, S.; Schweitzer, J.; Jahn, O.   & Werner, H. B.​ (2013) 
  Glia, 61(8) pp. 1364​-1377​.​ DOI: https://doi.org/10.1002/glia.22520 
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• 2014 | Journal Article
  ​ ​Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance​
  Mita, S.; de Monasterio-Schrader, P.; Fünfschilling, U.; Kawasaki, T.; Mizuno, H.; Iwasato, T. & Nave, K.-A. et al.​ (2014) 
  Cerebral Cortex, 25(11) pp. 4111​-4125​.​ DOI: https://doi.org/10.1093/cercor/bhu129 
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• 2014 | Journal Article
  ​ ​Progesterone Antagonist Therapy in a Pelizaeus-Merzbacher Mouse Model​
  Prukop, T.; Epplen, D. B.; Nientiedt, T.; Wichert, S. P.; Fledrich, R.; Stassart, R. M. & Rossner, M. J. et al.​ (2014) 
  The American Journal of Human Genetics, 94(4) pp. 533​-546​.​ DOI: https://doi.org/10.1016/j.ajhg.2014.03.001 
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• 2015 | Journal Article | 
  ​ ​Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease​
  Epplen, D. B.; Prukop, T.; Nientiedt, T.; Albrecht, P.; Arlt, F. A.; Stassart, R. M. & Kassmann, C. M. et al.​ (2015) 
  Annals of Clinical and Translational Neurology,.​ DOI: https://doi.org/10.1002/acn3.219 
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• 2016 | Journal Article
  ​ ​Proteolipid Protein Modulates Preservation of Peripheral Axons and Premature Death when Myelin Protein Zero is Lacking​
  Patzig, J.; Kusch, K.; Fledrich, R.; Eichel, M. A.; Lueders, K. A.; Möbius, W.   & Sereda, M. W. et al.​ (2016) 
  Glia, 64(1) pp. 155​-174​.​ DOI: https://doi.org/10.1002/glia.22922 
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• 2017 | Journal Article
  ​ ​Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis​
  Wang, L.; Winnewisser, J.; Federle, C.; Jessberger, G.; Nave, K.-A.; Werner, H. B. & Kyewski, B. et al.​ (2017) 
  Frontiers in Immunology, 8.​ DOI: https://doi.org/10.3389/fimmu.2017.01511 
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• 2017 | Journal Article | 
  ​ ​Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin​
  Snaidero, N.; Velte, C.; Myllykoski, M.; Raasakka, A.; Ignatev, A.; Werner, H. B. & Erwig, M. S. et al.​ (2017) 
  Cell Reports, 18(2) pp. 314​-323​.​ DOI: https://doi.org/10.1016/j.celrep.2016.12.053 
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• 2019 | Journal Article
  ​ ​Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons​
  Lüders, K. A.; Nessler, S.; Kusch, K.; Patzig, J.; Jung, R. B.; Möbius, W.   & Nave, K.-A. et al.​ (2019) 
  Glia, 67(4) pp. 634​-649​.​ DOI: https://doi.org/10.1002/glia.23549 
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• 2019 | Book Chapter
  ​ ​Myelin: Methods for Purification and Proteome Analysis​
  Erwig, M. S.; Hesse, D.; Jung, R. B.; Uecker, M.; Kusch, K.; Tenzer, S.& Jahn, O. et al.​ (2019)
  In:​Lyons, David A.; Kegel, Linde​ (Eds.), Methods in Molecular Biology Oligodendrocytes : Methods and Protocols pp. 37​-63. ​New York, NY: ​Springer New York. DOI: https://doi.org/10.1007/978-1-4939-9072-6_3 
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• 2019 | Journal Article | Research Paper
  ​ ​Myelinating Glia-Specific Deletion of Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy​
  Joseph, S.; Vingill, S.; Jahn, O. ; Fledrich, R.; Werner, H. B.; Katona, I. & Möbius, W.  et al.​ (2019) 
  The Journal of Neuroscience, 39(28) pp. 5606​-5626​.​ DOI: https://doi.org/10.1523/JNEUROSCI.3094-18.2019 
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• 2020 | Preprint
  ​ ​White matter integrity requires continuous myelin synthesis at the inner tongue​
  Meschkat, M.; Steyer, A. M.; Weil, M.-T.; Kusch, K.; Jahn, O.; Piepkorn, L.& Agüi-Gonzalez, P. et al.​ (2020). DOI: https://doi.org/10.1101/2020.09.02.279612 
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• 2020 | Journal Article
  ​ ​Oligodendrocytes support axonal transport and maintenance via exosome secretion​
  Frühbeis, C.; Kuo-Elsner, W. P.; Müller, C.; Barth, K.; Peris, L.; Tenzer, S. & Möbius, W.  et al.​ (2020) 
  PLOS Biology, 18(12) pp. e3000621​.​ DOI: https://doi.org/10.1371/journal.pbio.3000621 
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• 2020 | Journal Article | Research Paper
  ​ ​The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay​
  Jahn, O. ; Siems, S. B.; Kusch, K.; Hesse, D.; Jung, R. B.; Liepold, T. & Uecker, M. et al.​ (2020) 
  Frontiers in Cellular Neuroscience, 14 pp. 239​.​ DOI: https://doi.org/10.3389/fncel.2020.00239 
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• 2021 | Journal Article
  ​ ​Proteome Profile of Myelin in the Zebrafish Brain​
  Siems, S. B.; Jahn, O.; Hoodless, L. J.; Jung, R. B.; Hesse, D.; Möbius, W.   & Czopka, T. et al.​ (2021) 
  Frontiers in Cell and Developmental Biology, 9.​ DOI: https://doi.org/10.3389/fcell.2021.640169 
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• 2022 | Journal Article
  ​ ​Pinch2 is a novel regulator of myelination in the central nervous system​
  de Faria, J. P.; Vale-Silva, R. S.; Fässler, R.; Werner, H. B. & Relvas, J. B.​ (2022) 
  Development, art. dev.200597​.​ DOI: https://doi.org/10.1242/dev.200597 
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• 2022 | Preprint
  ​ ​Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity​
  Arinrad, S.; Depp, C.; Siems, S. B.; Sasmita, A. O.; Eichel, M. A.; Ronnenberg, A.& Hammerschmidt, K. et al.​ (2022). DOI: https://doi.org/10.1101/2022.11.21.517320 
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• 2022 | Journal Article | 
  ​ ​Focused ion beam‐scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag​
  Steyer, A. M.; Buscham, T. J.; Lorenz, C.; Hümmert, S.; Eichel‐Vogel, M. A.; Schadt, L. C. & Edgar, J. M. et al.​ (2022) 
  Glia, 71(3) art. glia.24290​.​ DOI: https://doi.org/10.1002/glia.24290 
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• 2023 | Journal Article
  ​ ​Mechanisms of axonal support by oligodendrocyte-derived extracellular vesicles​
  Krämer-Albers, E.-M. & Werner, H. B.​ (2023) 
  Nature Reviews Neuroscience,.​ DOI: https://doi.org/10.1038/s41583-023-00711-y 
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• 2024 | Journal Article
  ​ ​Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health​
  Looser, Z. J.; Faik, Z.; Ravotto, L.; Zanker, H. S.; Jung, R. B.; Werner, H. B. & Ruhwedel, T. et al.​ (2024) 
  Nature Neuroscience,.​ DOI: https://doi.org/10.1038/s41593-023-01558-3 
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