Author Spang, Rainer

• 2006 | Journal Article
  ​ ​A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling​
  Hummel, M.; Bentink, S.; Berger, H.; Klapper, W.; Wessendorf, S.; Barth, T. F. E. & Bernd, H. W. et al.​ (2006) 
  New England Journal of Medicine, 354(23) pp. 2419​-2430​.​ DOI: https://doi.org/10.1056/NEJMoa055351 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Conference Abstract
  ​ ​Conserved oncogenic module activation patterns (COMAPS) identify biologically homogeneous groups of diffuse large B-cell lymphomas and clearly define Burkitt lymphoma​
  Bentink, S.; Wessendorf, S.; Schwaenen, C.; Rosolowski, M.; Klapper, W.; Rosenwald, A. & Ott, G. et al.​ (2008)
  Annals of Oncology, 19 ​10th International Conference on Malignant Lymphoma​, Lugano, SWITZERLAND.
  Oxford​: Oxford Univ Press.
  ​Details  WoS 

• 2008 | Conference Abstract
  ​ ​Different subtypes of aggressive B cell lymphomas share an epigenetic signature enriched for polycomb targets in stem cells​
  Martin-Subero, J. I.; Kreuz, M.; Bibikova, M.; Bentink, S.; Klapper, W.; Wickham-Garcia, E. & Rosolowski, M. et al.​ (2008)
  Annals of Oncology, 19 ​10th International Conference on Malignant Lymphoma​, Lugano, SWITZERLAND.
  Oxford​: Oxford Univ Press.
  ​Details  WoS 

• 2008 | Journal Article
  ​ ​Pathway activation patterns in diffuse large B-cell lymphomas​
  Bentink, S.; Wessendorf, S.; Schwaenen, C.; Rosolowski, M.; Klapper, W.; Rosenwald, A. & Ott, G. et al.​ (2008) 
  Leukemia, 22(9) pp. 1746​-1754​.​ DOI: https://doi.org/10.1038/leu.2008.166 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article
  ​ ​Molecular profiling of pediatric mature B-cell lymphoma treated in population-based prospective clinical trials​
  Klapper, W.; Szczepanowski, M.; Burkhardt, B.; Berger, H.; Rosolowski, M.; Bentink, S. & Schwaenen, C. et al.​ (2008) 
  Blood, 112(4) pp. 1374​-1381​.​ DOI: https://doi.org/10.1182/blood-2008-01-136465 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article
  ​ ​Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma​
  Dierlamm, J.; Penas, E. M. M.; Bentink, S.; Wessendorf, S.; Berger, H.; Hummel, M. & Klapper, W. et al.​ (2008) 
  HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 93(5) pp. 688​-696​.​ DOI: https://doi.org/10.3324/haematol.12057 
  ​Details  DOI  PMID  PMC  WoS 

• 2008 | Journal Article
  ​ ​Analyzing gene perturbation screens with nested effects models in R and bioconductor​
  Fröhlich, H.; Beißbarth, T. ; Tresch, A.; Kostka, D.; Jacob, J.; Spang, R. & Markowetz, F.​ (2008) 
  Bioinformatics, 24(21) pp. 2549​-2550​.​ DOI: https://doi.org/10.1093/bioinformatics/btn446 
  ​Details  DOI  PMID  PMC 

• 2009 | Journal Article
  ​ ​Microarray-Based Genomic Profiling Reveals Novel Genomic Aberrations in Follicular War Lymphoma Which Associate with Patient Survival and Gene Expression Status​
  Schwaenen, C.; Viardot, A.; Berger, H.; Barth, T. F. E.; Bentink, S.; Doehner, H. & Enz, M. et al.​ (2009) 
  Genes Chromosomes and Cancer, 48(1) pp. 39​-54​.​ DOI: https://doi.org/10.1002/gcc.20617 
  ​Details  DOI  PMID  PMC  WoS 

• 2009 | Journal Article
  ​ ​New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling​
  Martin-Subero, J. I.; Kreuz, M.; Bibikova, M.; Bentink, S.; Ammerpohl, O.; Wickham-Garcia, E. & Rosolowski, M. et al.​ (2009) 
  Blood, 113(11) pp. 2488​-2497​.​ DOI: https://doi.org/10.1182/blood-2008-04-152900 
  ​Details  DOI  PMID  PMC  WoS 

• 2010 | Conference Abstract
  ​ ​A c-Myc induced gene expression signature in human germinal center B cells predicts subtypes of aggressive non-Hodgkin Lymphoma​
  Schrader, A.; Bentink, S.; Spang, R.; Lenze, D.; Hummel, M.; Kuo, M. & Murray, P. et al.​ (2010)
  EJC SUPPLEMENTS, 8(5) ​21st Meeting of the European-Association-for-Cancer-Research​, Oslo, NORWAY.
  Oxford​: Pergamon-elsevier Science Ltd.
  ​Details  WoS 

• 2010 | Journal Article | 
  ​ ​Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis​
  Scholtysik, R.; Kreuz, M.; Klapper, W.; Burkhardt, B.; Feller, A. C.; Hummel, M. & Loeffler, M. et al.​ (2010) 
  HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 95(12) pp. 2047​-2055​.​ DOI: https://doi.org/10.3324/haematol.2010.026831 
  ​Details  DOI  PMID  PMC  WoS 

• 2011 | Journal Article
  ​ ​Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults​
  Salaverria, I.; Philipp, C.; Oschlies, I.; Kohler, C. W.; Kreuz, M.; Szczepanowski, M. & Burkhardt, B. et al.​ (2011) 
  Blood, 118(1) pp. 139​-147​.​ DOI: https://doi.org/10.1182/blood-2011-01-330795 
  ​Details  DOI  PMID  PMC  WoS 

• 2011 | Journal Article
  ​ ​Genomic data integration using guided clustering​
  Maneck, M.; Schrader, A.; Kube, D. & Spang, R.​ (2011) 
  Bioinformatics, 27(16) pp. 2231​-2238​.​ DOI: https://doi.org/10.1093/bioinformatics/btr363 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Conference Abstract
  ​ ​SOCS1 Mutation Subtypes Predict Divergent Outcomes in DLBCL Patients​
  Lennerz, J. K.; Schif, B.; Kohler, C. W.; Bentink, S.; Kreuz, M.; Melzner, I. & Truemper, L. H. et al.​ (2012)
  Blood, 120(21) ​54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)​, Atlanta, GA.
  Washington​: Amer Soc Hematology.
  ​Details  WoS 

• 2012 | Journal Article
  ​ ​Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing​
  Richter, J.; Schlesner, M.; Hoffmann, S.; Kreuz, M.; Leich, E.; Burkhardt, B. & Rosolowski, M. et al.​ (2012) 
  Nature Genetics, 44(12) pp. 1316​-1320​.​ DOI: https://doi.org/10.1038/ng.2469 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Journal Article
  ​ ​T cells become licensed in the lung to enter the central nervous system​
  Odoardi, F. ; Sie, C.; Streyl, K.; Ulaganathan, V. K.; Schlaeger, C.; Lodygin, D. & Heckelsmiller, K. et al.​ (2012) 
  Nature, 488(7413) pp. 675​.​ DOI: https://doi.org/10.1038/nature11337 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Journal Article
  ​ ​High myc activity is an independent negative prognostic factor for diffuse large B cell lymphomas​
  Schrader, A.; Bentink, S.; Spang, R.; Lenze, D.; Hummel, M.; Kuo, M. & Arrand, J. R. et al.​ (2012) 
  International Journal of Cancer, 131(4) pp. E348​-E361​.​ DOI: https://doi.org/10.1002/ijc.26423 
  ​Details  DOI  PMID  PMC  WoS 

• 2012 | Journal Article
  ​ ​Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma​
  Klapper, W.; Kreuz, M.; Kohler, C. W.; Burkhardt, B.; Szczepanowski, M.; Salaverria, I. & Hummel, M. et al.​ (2012) 
  Blood, 119(8) pp. 1882​-1887​.​ DOI: https://doi.org/10.1182/blood-2011-10-388470 
  ​Details  DOI  PMID  PMC  WoS 

• 2013 | Journal Article | 
  ​ ​SOCS1 mutation subtypes predict divergent outcomes in diffuse large B-Cell lymphoma (DLBCL) patients.​
  Schif, B.; Lennerz, J. K.; Kohler, C. W.; Bentink, S.; Kreuz, M.; Melzner, I. & Ritz, O. et al.​ (2013) 
  Oncotarget, 4(1) pp. 35​-47​.​
  ​Details  PMID  PMC 

• 2014 | Journal Article | 
  ​ ​Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma​
  Aukema, S. M.; Kreuz, M.; Kohler, C. W.; Rosolowski, M.; Hasenclever, D.; Hummel, M. & Kueppers, R. et al.​ (2014) 
  Haematologica, 99(4) pp. 726​-735​.​ DOI: https://doi.org/10.3324/haematol.2013.091827 
  ​Details  DOI  PMID  PMC  WoS 

• 2014 | Journal Article
  ​ ​A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma​
  Salaverria, I.; Martin-Guerrero, I.; Wagener, R.; Kreuz, M.; Kohler, C. W.; Richter, J. & Pienkowska-Grela, B. et al.​ (2014) 
  Blood, 123(8) pp. 1187​-1198​.​ DOI: https://doi.org/10.1182/blood-2013-06-507996 
  ​Details  DOI  PMID  PMC  WoS 

• 2016 | Journal Article | 
  ​ ​Analyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models​
  Pirkl, M.; Hand, E.; Kube, D. & Spang, R.​ (2016) 
  Bioinformatics, 32(6) pp. 893​-900​.​ DOI: https://doi.org/10.1093/bioinformatics/btv680 
  ​Details  DOI  PMID  PMC  WoS 

• 2016 | Journal Article | 
  ​ ​Identification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression data​
  Schrader, A.; Meyer, K.; Walther, N.; Stolz, A.; Feist, M. ; Hand, E. & von Bonin, F. et al.​ (2016) 
  Oncotarget, 7(30) pp. 47061​-47081​.​ DOI: https://doi.org/10.18632/oncotarget.9219 
  ​Details  DOI  PMID  PMC  WoS 

• 2017 | Journal Article
  ​ ​Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC​
  Paul, U.; Richter, J.; Stuhlmann-Laiesz, C.; Kreuz, M.; Nagel, I.; Horn, H. & Staiger, A. M. et al.​ (2017) 
  Leukemia & Lymphoma, 59(5) pp. 1213​-1221​.​ DOI: https://doi.org/10.1080/10428194.2017.1365851 
  ​Details  DOI 

• 2017 | Journal Article
  ​ ​Comprehensive Metaboproteomics of Burkitt's and Diffuse Large B-Cell Lymphoma Cell Lines and Primary Tumor Tissues Reveals Distinct Differences in Pyruvate Content and Metabolism​
  Schwarzfischer, P.; Reinders, J.; Dettmer, K.; Kleo, K.; Dimitrova, L.; Hummel, M. & Feist, M. et al.​ (2017) 
  Journal of Proteome Research, 16(3) pp. 1105​-+​.​ DOI: https://doi.org/10.1021/acs.jproteome.6b00164 
  ​Details  DOI  PMID  PMC  WoS 

• 2017 | Journal Article | Research Paper
  ​ ​Cell-of-origin classification by gene expression and MYC-rearrangements in diffuse large B-cell lymphoma of children and adolescents​
  Szczepanowski, M.; Lange, J.; Kohler, C. W.; Masque-Soler, N.; Zimmermann, M.; Aukema, S. M. & Altenbuchinger, M.  et al.​ (2017) 
  British Journal of Haematology, 179(1) pp. 116​-119​.​ DOI: https://doi.org/10.1111/bjh.14812 
  ​Details  DOI  PMID  PMC 

• 2017 | Journal Article | Research Paper
  ​ ​Scale-Invariant Biomarker Discovery in Urine and Plasma Metabolite Fingerprints​
  Zacharias, H. U.; Rehberg, T.; Mehrl, S.; Richtmann, D.; Wettig, T.; Oefner, P. J. & Spang, R. et al.​ (2017) 
  Journal of Proteome Research, 16(10) pp. 3596​-3605​.​ DOI: https://doi.org/10.1021/acs.jproteome.7b00325 
  ​Details  DOI  PMID  PMC  arXiv 

• 2017 | Journal Article
  ​ ​External calibration with Drosophila whole-cell spike-ins delivers absolute mRNA fold changes from human RNA-Seq and qPCR data​
  Taruttis, F.; Feist, M.; Schwarzfischer, P.; Gronwald, W.; Kube, D.; Spang, R. & Engelmann, J. C.​ (2017) 
  BioTechniques, 62(2) pp. 53​-61​.​ DOI: https://doi.org/10.2144/000114514 
  ​Details  DOI  PMID  PMC  WoS 

• 2017 | Journal Article
  ​ ​Synergy of interleukin 10 and toll-like receptor 9 signalling in B cell proliferation: Implications for lymphoma pathogenesis​
  Feist, M.; Kemper, J.; Taruttis, F.; Rehberg, T.; Engelmann, J. C.; Gronwald, W. & Hummel, M. et al.​ (2017) 
  International Journal of Cancer, 140(5) pp. 1147​-1158​.​ DOI: https://doi.org/10.1002/ijc.30444 
  ​Details  DOI  PMID  PMC  WoS 

• 2018 | Journal Article
  ​ ​Gene expression profiling reveals a close relationship between follicular lymphoma grade 3A and 3B, but distinct profiles of follicular lymphoma grade 1 and 2​
  Horn, H.; Kohler, C.; Witzig, R.; Kreuz, M.; Leich, E.; Klapper, W. & Hummel, M. et al.​ (2018) 
  Haematologica, 103(7) pp. 1182​-1190​.​ DOI: https://doi.org/10.3324/haematol.2017.181024 
  ​Details  DOI 

• 2018 | Conference Paper
  ​ ​Loss-Function Learning for Digital Tissue Deconvolution​
  Görtler, F.; Solbrig, S.; Wettig, T.; Oefner, P. J.; Spang, R. & Altenbuchinger, M. ​ (2018)
  In:Raphael, Benjamin J.​ (Ed.), ​Research in Computational Molecular Biology pp. 75​-89. ​22nd Annual International Conference, RECOMB 2018​, Paris.
  Springer. DOI: https://doi.org/10.1007/978-3-319-89929-9_5 
  ​Details  DOI 

• 2018 | Journal Article | Research Paper
  ​ ​Principles of Systems Biology, No. 31​
  Cho, H.; Berger, B.; Peng, J.; Galitzine, C.; Vitek, O.; Beltran, P. M. J. & Cristea, I. M. et al.​ (2018) 
  Cell Systems, 7(2) pp. 133​-135​.​ DOI: https://doi.org/10.1016/j.cels.2018.08.005 
  ​Details  DOI  PMID  PMC 

• 2018 | Journal Article | Research Paper
  ​ ​Round-robin test for the cell-of-origin classification of diffuse large B-cell lymphoma—a feasibility study using full slide staining​
  Reinke, S.; Richter, J.; Fend, F.; Feller, A.; Hansmann, M.-L.; Hüttl, K. & Oschlies, I. et al.​ (2018) 
  Virchows Archiv, 473(3) pp. 341​-349​.​ DOI: https://doi.org/10.1007/s00428-018-2367-4 
  ​Details  DOI 

• 2018 | Journal Article
  ​ ​A New Stromal Signature Applicable to Formalin-Fixed Paraffin-Embedded Tissues Identifies Patients at Risk in Prospective Clinical Trials of the German High-Grade Non-Hodgkin Lymphoma Study Group​
  Staiger, A. M.; Altenbuchinger, M.; Ziepert, M.; Kohler, C.; Horn, H.; Huttner, M. & Huettl, K. et al.​ (2018) 
  Blood, 132(Supplement 1) pp. 343​-343​.​ DOI: https://doi.org/10.1182/blood-2018-99-112450 
  ​Details  DOI 

• 2018 | Journal Article | 
  ​ ​Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression.​
  Feist, M.; Schwarzfischer, P.; Heinrich, P.; Sun, X.; Kemper, J.; von Bonin, F. & Perez-Rubio, P. et al.​ (2018) 
  Nature communications, 9(1) art. 1514​.​ DOI: https://doi.org/10.1038/s41467-018-03803-x 
  ​Details  DOI  PMID  PMC 

• 2019 | Journal Article
  ​ ​A novel lymphoma-associated macrophage interaction signature (LAMIS) provides robust risk prognostication in diffuse large B-cell lymphoma clinical trial cohorts of the DSHNHL​
  Staiger, A. M.; Altenbuchinger, M. ; Ziepert, M.; Kohler, C.; Horn, H.; Huttner, M. & Hüttl, K. S. et al.​ (2019) 
  Leukemia, 34(2) pp. 543​-552​.​ DOI: https://doi.org/10.1038/s41375-019-0573-y 
  ​Details  DOI 

• 2019 | Journal Article | Research Paper | 
  ​ ​Automated macrophage counting in DLBCL tissue samples: a ROF filter based approach​
  Wagner, M.; Hänsel, R.; Reinke, S.; Richter, J.; Altenbuchinger, M. ; Braumann, U.-D. & Spang, R. et al.​ (2019) 
  Biological Procedures Online, 21(1) pp. 13​.​ DOI: https://doi.org/10.1186/s12575-019-0098-9 
  ​Details  DOI  PMID  PMC 

• 2019 | Journal Article | Research Paper
  ​ ​A Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease​
  Zacharias, H. U.; Altenbuchinger, M. ; Schultheiss, U. T.; Samol, C.; Kotsis, F.; Poguntke, I. & Sekula, P. et al.​ (2019) 
  Journal of Proteome Research, 18(4) pp. 1796​-1805​.​ DOI: https://doi.org/10.1021/acs.jproteome.8b00983 
  ​Details  DOI  PMID  PMC 

• 2019 | Journal Article | Research Paper | 
  ​ ​A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study​
  Altenbuchinger, M. ; Zacharias, H. U.; Solbrig, S.; Schäfer, A.; Büyüközkan, M.; Schultheiß, U. T. & Kotsis, F. et al.​ (2019) 
  Scientific Reports, 9(1) art. 13954​.​ DOI: https://doi.org/10.1038/s41598-019-50346-2 
  ​Details  DOI  PMID  PMC 

• 2020 | Journal Article | 
  ​ ​High CD206 levels in Hodgkin lymphoma‐educated macrophages are linked to matrix‐remodeling and lymphoma dissemination​
  Arlt, A. ; Bonin, F. ; Rehberg, T.; Perez‐Rubio, P.; Engelmann, J. C.; Limm, K. & Reinke, S. et al.​ (2020) 
  Molecular Oncology, 14(3) pp. 571​-589​.​ DOI: https://doi.org/10.1002/1878-0261.12616 
  ​Details  DOI 

• 2020 | Journal Article | Research Paper
  ​ ​DTD: An R Package for Digital Tissue Deconvolution​
  Schön, M.; Simeth, J.; Heinrich, P.; Görtler, F.; Solbrig, S.; Wettig, T. & Oefner, P. J. et al.​ (2020) 
  Journal of Computational Biology, 27(3) pp. 386​-389​.​ DOI: https://doi.org/10.1089/cmb.2019.0469 
  ​Details  DOI  PMID  PMC 

• 2020 | Journal Article | Research Paper | 
  ​ ​Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue​
  Reinders, J.; Altenbuchinger, M. ; Limm, K.; Schwarzfischer, P.; Scheidt, T.; Strasser, L. & Richter, J. et al.​ (2020) 
  Scientific Reports, 10(1) pp. 7876​.​ DOI: https://doi.org/10.1038/s41598-020-64212-z 
  ​Details  DOI  PMID  PMC 

• 2021 | Journal Article | Research Paper
  ​ ​Identification of a miRNA based model to detect prognostic subgroups in patients with aggressive B-cell lymphoma​
  Nordmo, C.; Glehr, G.; Altenbuchinger, M. ; Spang, R.; Ziepert, M.; Horn, H. & Staiger, A. M. et al.​ (2021) 
  Leukemia & Lymphoma, 62(5) pp. 1107​-1115​.​ DOI: https://doi.org/10.1080/10428194.2020.1861268 
  ​Details  DOI  PMID  PMC 

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