Author Ruhwedel, Torben
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2010 | Book Chapter
Electron Microscopy of the Mouse Central Nervous System
Möbius, W. ; Cooper, B.; Kaufmann, W. A.; Imig, C.; Ruhwedel, T.; Snaidero, N.& Saab, A. S. et al. (2010)
In: Electron Microscopy of Model Systems pp. 475-512. Elsevier. DOI: https://doi.org/10.1016/S0091-679X(10)96020-2
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2011 | Journal Article
Aspartoacylase-LacZ Knockin Mice: An Engineered Model of Canavan Disease
Mersmann, N.; Tkachev, D.; Jelinek, R.; Röth, P. T.; Möbius, W. ; Ruhwedel, T. & Rühle, S. et al. (2011)
PLoS ONE, 6(5) pp. e20336. DOI: https://doi.org/10.1371/journal.pone.0020336
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2012 | Journal Article |
Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy
Goebbels, S.; Oltrogge, J. H.; Wolfer, S.; Wieser, G. L.; Nientiedt, T.; Pieper, A. & Ruhwedel, T. et al. (2012)
EMBO Molecular Medicine, 4(6) pp. 486-499. DOI: https://doi.org/10.1002/emmm.201200227
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2012 | Journal Article
Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet
Saher, G.; Rudolphi, F.; Corthals, K.; Ruhwedel, T.; Schmidt, K.-F.; Loewel, S. & Dibaj, P. et al. (2012)
Nature Medicine, 18(7) pp. 1130-+. DOI: https://doi.org/10.1038/nm.2833
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2013 | Journal Article
Cryo FIB-SEM: Volume imaging of cellular ultrastructure in native frozen specimens
Schertel, A.; Snaidero, N.; Han, H.-M.; Ruhwedel, T.; Laue, M.; Grabenbauer, M. & Möbius, W. (2013)
Journal of Structural Biology, 184(2) pp. 355-360. DOI: https://doi.org/10.1016/j.jsb.2013.09.024
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2014 | Journal Article |
Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice.
Gritsch, S.; Lu, J.; Thilemann, S.; Wörtge, S.; Möbius, W. ; Bruttger, J. & Karram, K. et al. (2014)
Nature communications, 5 art. 5472. DOI: https://doi.org/10.1038/ncomms6472
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2015 | Conference Abstract
Molecular mechanism of myelin disassembly
Weil, M.-T.; Möbius, W. ; Ruhwedel, T.; Frey, S.; Kursula, P.; Winkler, A. & Stadelmann-Nessler, C. et al. (2015)
Glia, 63 , Bilbao, SPAIN.
Hoboken: Wiley-blackwell.
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2016 | Conference Abstract
Non-keratinocyte SNAP29 influences epidermal differentiation and hair follicle formation in mice
Schiller, S.; Seebode, C.; Wieser, G.; Goebbels, S.; Ruhwedel, T.; Horowitz, M. & Rapaport, D. et al. (2016)
Experimental Dermatology, 25(3) 43rd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung-e-V (ADF), Vienna, AUSTRIA.
Hoboken: Wiley-blackwell.
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2016 | Journal Article |
Cortical network dysfunction caused by a subtle defect of myelination
Poggi, G.; Boretius, S. ; Möbius, W. ; Moschny, N.; Baudewig, J. ; Ruhwedel, T. & Hassouna, I. et al. (2016)
Glia, 64(11) pp. 2025-2040. DOI: https://doi.org/10.1002/glia.23039
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2016 | Journal Article
Non-keratinocyte SNAP29 influences epidermal differentiation and hair follicle formation in mice
Schiller, S. A.; Seebode, C.; Wieser, G. L.; Goebbels, S.; Ruhwedel, T.; Horowitz, M. & Rapaport, D. et al. (2016)
Experimental Dermatology, 25(8) pp. 647-649. DOI: https://doi.org/10.1111/exd.13050
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2016 | Journal Article |
Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
Weil, M.-T.; Möbius, W. ; Winkler, A.; Ruhwedel, T.; Wrzos, C.; Romanelli, E. & Bennett, J. L. et al. (2016)
Cell Reports, 16(2) pp. 314-322. DOI: https://doi.org/10.1016/j.celrep.2016.06.008
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2017 | Conference Abstract
Temporal sound processing in the auditory cortex is influenced by changes in myelin integrity
Moore, S.; Möbius, W. ; Ruhwedel, T.; Weil, M.-T.; Nave, K.-A. & de Hoz, L. (2017)
Glia, 65 pp. E396-E397. 13th European Meeting on Glial Cells in Health and Disease, Edinburgh, SCOTLAND.
Hoboken: Wiley.
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2017 | Journal Article |
Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model
Berghoff, S. A.; Düking, T.; Spieth, L.; Winchenbach, J.; Stumpf, S. K.; Gerndt, N. & Kusch, K. et al. (2017)
Acta Neuropathologica Communications, 5(1). DOI: https://doi.org/10.1186/s40478-017-0497-6
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2017 | Journal Article |
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain
Berghoff, S. A.; Gerndt, N.; Winchenbach, J.; Stumpf, S. K.; Hosang, L.; Odoardi, F. & Ruhwedel, T. et al. (2017)
Nature Communications, 8 art. 14241. DOI: https://doi.org/10.1038/ncomms14241
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2017 | Journal Article | Research Paper |
Phase-contrast tomography of sciatic nerves: image quality and experimental parameters
Töpperwien, M. ; Krenkel, M.; Ruhwedel, T.; Möbius, W. ; Pacureanu, A.; Cloetens, P. & Salditt, T. (2017)
Journal of Physics. Conference Series, 849 art. 012001. DOI: https://doi.org/10.1088/1742-6596/849/1/012001
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2018 | Journal Article
Defective cholesterol clearance limits remyelination in the aged central nervous system
Cantuti-Castelvetri, L.; Fitzner, D.; Bosch-Queralt, M.; Weil, M.-T.; Su, M.; Sen, P. & Ruhwedel, T. et al. (2018)
Science, 359(6376) pp. 684-688. DOI: https://doi.org/10.1126/science.aan4183
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2018 | Journal Article | Research Paper
Axonal Ensheathment in the Nervous System of Lamprey: Implications for the Evolution of Myelinating Glia
Weil, M.-T.; Heibeck, S.; Töpperwien, M. ; tom Dieck, S.; Ruhwedel, T.; Salditt, T. & Rodicio, M. C. et al. (2018)
The Journal of Neuroscience, 38(29) pp. 6586-6596. DOI: https://doi.org/10.1523/JNEUROSCI.1034-18.2018
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2019 | Journal Article
Biological Sample Preparation by High-pressure Freezing, Microwave-assisted Contrast Enhancement, and Minimal Resin Embedding for Volume Imaging
Steyer, A. M.; Ruhwedel, T. & Möbius, W. (2019)
Journal of Visualized Experiments,(145). DOI: https://doi.org/10.3791/59156
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2019 | Book Chapter
Transmission Electron Microscopy of Oligodendrocytes and Myelin
Weil, M.-T.; Ruhwedel, T.; Meschkat, M.; Sadowski, B.& Möbius, W. (2019)
In:Lyons, David A.; Kegel, Linde (Eds.), Oligodendrocytes : Methods and Protocols pp. 343-375. New York, NY: Springer New York. DOI: https://doi.org/10.1007/978-1-4939-9072-6_20
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2019 | Journal Article |
Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease
Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A. ; Spieth, L.; Düking, T.; Schneider, L. V. & Schlaphoff, L. et al. (2019)
Acta Neuropathologica, 138(1) pp. 147-161. DOI: https://doi.org/10.1007/s00401-019-01985-2
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2019 | Journal Article | Erratum |
Correction to: Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease
Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A.; Spieth, L.; Düking, T.; Schneider, L. V. & Schlaphoff, L. et al. (2019)
Acta Neuropathologica, 138(4) pp. 673-674. DOI: https://doi.org/10.1007/s00401-019-02064-2
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2019 | Conference Paper
Evaluation of different heavy-metal stains and embedding media for phase contrast tomography of neuronal tissue
Eckermann, M.; Töpperwien, M. ; Ruhwedel, T.; Möbius, W. & Salditt, T. (2019)
In:Müller-Myhsok, Bertram; Wang, Geng (Eds.), Proc. SPIE 11113 p. 21. (Vol. 12). , San Diego, California, United States. DOI: https://doi.org/10.1117/12.2528432
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2020 | Preprint
White matter integrity requires continuous myelin synthesis at the inner tongue
Meschkat, M.; Steyer, A. M.; Weil, M.-T.; Kusch, K.; Jahn, O.; Piepkorn, L.& Agüi-Gonzalez, P. et al. (2020). DOI: https://doi.org/10.1101/2020.09.02.279612
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2020 | Journal Article
Neuronal activity disrupts myelinated axon integrity in the absence of NKCC1b
Marshall-Phelps, K. L.; Kegel, L.; Baraban, M.; Ruhwedel, T.; Almeida, R. G.; Rubio-Brotons, M. & Klingseisen, A. et al. (2020)
Journal of Cell Biology, 219(7). DOI: https://doi.org/10.1083/jcb.201909022
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2020 | Journal Article
Intranasal mesenchymal stem cell therapy to boost myelination after encephalopathy of prematurity
Vaes, J. E. G.; Kammen, C. M.; Trayford, C.; Toorn, A.; Ruhwedel, T.; Benders, M. J. N. L. & Dijkhuizen, R. M. et al. (2020)
Glia, 69(3) pp. 655-680. DOI: https://doi.org/10.1002/glia.23919
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2020 | Journal Article |
A role of oligodendrocytes in information processing
Moore, S.; Meschkat, M.; Ruhwedel, T.; Trevisiol, A. ; Tzvetanova, I. D.; Battefeld, A. & Kusch, K. et al. (2020)
Nature Communications, 11(1). DOI: https://doi.org/10.1038/s41467-020-19152-7
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2020 | Journal Article | Research Paper
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L. ; Schlaphoff, L.; Depp, C. & Düking, T. et al. (2020)
Nature Neuroscience, 24(1) pp. 47-60. DOI: https://doi.org/10.1038/s41593-020-00757-6
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2020 | Journal Article | Research Paper |
Pathology of myelinated axons in the PLP-deficient mouse model of spastic paraplegia type 2 revealed by volume imaging using focused ion beam-scanning electron microscopy
Steyer, A. M.; Ruhwedel, T.; Nardis, C.; Werner, H. B. ; Nave, K.-A. & Möbius, W. (2020)
Journal of Structural Biology, 210(2) art. S1047847720300587. DOI: https://doi.org/10.1016/j.jsb.2020.107492
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2020 | Journal Article | Research Paper |
Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination
Lohrberg, M.; Winkler, A.; Franz, J.; van der Meer, F.; Ruhwedel, T.; Sirmpilatze, N. & Dadarwal, R. et al. (2020)
Acta Neuropathologica Communications, 8(1) pp. 224. DOI: https://doi.org/10.1186/s40478-020-01105-2
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2021 | Preprint
Myelin biogenesis is associated with pathological ultrastructure that is resolved by microglia during development
Djannatian, M.; Weikert, U.; Safaiyan, S.; Wrede, C.; Deichsel, C.; Kislinger, G.& Ruhwedel, T. et al. (2021). DOI: https://doi.org/10.1101/2021.02.02.429485
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2021 | Journal Article
Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport
Spieth, L.; Berghoff, S. A; Stumpf, S. K; Winchenbach, J.; Michaelis, T.; Watanabe, T. & Gerndt, N. et al. (2021)
Neuro-Oncology Advances, 3(1) art. vdab140. DOI: https://doi.org/10.1093/noajnl/vdab140
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2021 | Journal Article | Research Paper |
New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea
Möbius, W. ; Hümmert, S.; Ruhwedel, T.; Kuzirian, A. & Gould, R. (2021)
Life, 11(2) pp. 136. DOI: https://doi.org/10.3390/life11020136
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2021 | Journal Article | Research Paper
Three-dimensional virtual histology of the cerebral cortex based on phase-contrast X-ray tomography
Eckermann, M.; van der Meer, F.; Cloetens, P.; Ruhwedel, T.; Möbius, W. ; Stadelmann, C. & Salditt, T. (2021)
Biomedical Optics Express, 12(12) pp. 7582. DOI: https://doi.org/10.1364/BOE.434885
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2021 | Journal Article |
WNT11/ROR2 signaling is associated with tumor invasion and poor survival in breast cancer
Menck, K.; Heinrichs, S.; Wlochowitz, D.; Sitte, M.; Noeding, H.; Janshoff, A. & Treiber, H. et al. (2021)
Journal of Experimental & Clinical Cancer Research, 40(1) art. 395. DOI: https://doi.org/10.1186/s13046-021-02187-z
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2022 | Preprint
Myelin lipids as nervous system energy reserves
Asadollahi, E.; Trevisiol, A.; Saab, A. S.; Looser, Z. J.; Dibaj, P.; Kusch, K.& Ruhwedel, T. et al. (2022). DOI: https://doi.org/10.1101/2022.02.24.481621
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2022 | Journal Article | Research Paper |
White matter integrity in mice requires continuous myelin synthesis at the inner tongue
Meschkat, M.; Steyer, A. M.; Weil, M.-T.; Kusch, K. ; Jahn, O. ; Piepkorn, L. & Agüi-Gonzalez, P. et al. (2022)
Nature Communications, 13(1) art. 1163. DOI: https://doi.org/10.1038/s41467-022-28720-y
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2022 | Journal Article
Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment
Cheng, S.; Altmeppen, G.; So, C.; Welp, L. M.; Penir, S.; Ruhwedel, T. & Menelaou, K. et al. (2022)
Science, 378(6617) art. eabq4835. DOI: https://doi.org/10.1126/science.abq4835
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2023 | Journal Article
Ultrastructural Axon–Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation
van den Bosch, A. M. R.; Hümmert, S.; Steyer, A.; Ruhwedel, T.; Hamann, J.; Smolders, J. & Nave, K. et al. (2023)
Annals of Neurology, art. ana.26585. DOI: https://doi.org/10.1002/ana.26585
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2023 | Journal Article
Mammalian Oocytes Store mRNAs in a Mitochondria-Associated Membraneless Compartment
Cheng, S.; Altmeppen, G.; So, C.; Welp, L. M.; Penir, S.; Ruhwedel, T. & Menelaou, K. et al. (2023)
Obstetrical & Gynecological Survey, 78(5) pp. 280-281. DOI: https://doi.org/10.1097/OGX.0000000000001149
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2023 | Journal Article
Convergent evolution of the sensory pits in and within flatworms
Gąsiorowski, L.; Dittmann, I. L.; Brand, J. N.; Ruhwedel, T.; Möbius, W.; Egger, B. & Rink, J. C. (2023)
BMC Biology, 21(1). DOI: https://doi.org/10.1186/s12915-023-01768-y
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2023 | Preprint
Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer’s disease
Sasmita, A. O.; Depp, C.; Nazarenko, T.; Sun, T.; Siems, S. B.; Yu, X.& Boehler, C. et al. (2023). DOI: https://doi.org/10.1101/2023.12.11.570514
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2023 | Journal Article
Myelination generates aberrant ultrastructure that is resolved by microglia
Djannatian, M.; Radha, S.; Weikert, U.; Safaiyan, S.; Wrede, C.; Deichsel, C. & Kislinger, G. et al. (2023)
Journal of Cell Biology, 222(3) art. e202204010. DOI: https://doi.org/10.1083/jcb.202204010
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2023 | Journal Article
Neodymium acetate as a contrast agent for x-ray phase-contrast tomography
Reichmann, J. ; Ruhwedel, T.; Möbius, W. & Salditt, T. (2023)
Journal of Medical Imaging, 10(5) art. 056001. DOI: https://doi.org/10.1117/1.JMI.10.5.056001
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2024 | Journal Article
Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health
Looser, Z. J.; Faik, Z.; Ravotto, L.; Zanker, H. S.; Jung, R. B.; Werner, H. B. & Ruhwedel, T. et al. (2024)
Nature Neuroscience,. DOI: https://doi.org/10.1038/s41593-023-01558-3
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