Author Nau, R.

• 2000 | Journal Article
  ​ ​Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus​
  Ehrenreich, H.; Nau, R.; Dembowski, C.; Hasselblatt, M.; Barth, M.; Hahn, A. & Schilling, L. et al.​ (2000) 
  Neuroscience, 95(4) pp. 993​-1001​.​
  ​Details  PMID  PMC  WoS 

• 2000 | Journal Article
  ​ ​Follistatin (FS) in human cerebrospinal fluid and regulation of FS expression in a mouse model of meningitis​
  Michel, W.; Ebert, S.; Schneider, O.; Shintani, Y.; Bunkowski, S.; Smirnov, A. & Stringaris, A. K. et al.​ (2000) 
  European Journal of Endocrinology, 143(6) pp. 809​-816​.​
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• 2000 | Journal Article
  ​ ​Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus​
  Tumani, H.; Smirnov, A.; Barchfeld, S.; Olgemoller, U.; Maier, K.; Lange, P. & Bruck, W. W. et al.​ (2000) 
  Glia, 30(1) pp. 11​-18​.​ DOI: https://doi.org/10.1002/(SICI)1098-1136(200003)30:1<11::AID-GLIA2>3.0.CO;2-E 
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• 2000 | Journal Article
  ​ ​Induction of necrosis and apoptosis of neutrophil granulocytes by Streptococcus pneumoniae​
  Zysk, G.; Bejo, L.; Schneider-Wald, B. K.; Nau, R. & Heinz, H. P.​ (2000) 
  Clinical & Experimental Immunology, 122(1) pp. 61​-66​.​ DOI: https://doi.org/10.1046/j.1365-2249.2000.01336.x 
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• 2000 | Journal Article
  ​ ​Gemifloxacin is effective in experimental pneumococcal meningitis​
  Smirnov, A.; Wellmer, A.; Gerber, J.; Maier, K.; Henne, S. & Nau, R.​ (2000) 
  Antimicrobial Agents and Chemotherapy, 44(3) pp. 767​-770​.​ DOI: https://doi.org/10.1128/AAC.44.3.767-770.2000 
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• 2000 | Review
  ​ ​Osmotherapy for elevated intracranial pressure - A critical reappraisal​
  Nau, R.​ (2000)
  Clinical Pharmacokinetics, 38​(1) pp. 23​-40​.​
  Adis International Ltd. DOI: https://doi.org/10.2165/00003088-200038010-00002 
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• 2000 | Journal Article
  ​ ​Spatial memory and learning deficits after experimental pneumococcal meningitis in mice​
  Wellmer, A.; Noeske, C.; Gerber, J.; Munzel, U. & Nau, R.​ (2000) 
  Neuroscience Letters, 296(2-3) pp. 137​-140​.​ DOI: https://doi.org/10.1016/S0304-3940(00)01645-1 
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• 2000 | Journal Article
  ​ ​Comparative analysis of follistatin-, activin beta A- and activin beta B-mRNA steady-state levels in diverse porcine tissues by multiplex S1 nuclease analysis​
  Schneider, O.; Nau, R. & Michel, U.​ (2000) 
  European Journal of Endocrinology, 142(5) pp. 537​-544​.​ DOI: https://doi.org/10.1530/eje.0.1420537 
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• 2000 | Journal Article
  ​ ​Rifampin reduces production of reactive oxygen species of cerebrospinal fluid phagocytes and hippocampal neuronal apoptosis in experimental Streptococcus pneumoniae meningitis​
  Bottcher, T.; Gerber, J.; Wellmer, A.; Smirnov, A. V.; Fakhrjanali, F.; Mix, E. & Pilz, J. et al.​ (2000) 
  The Journal of Infectious Diseases, 181(6) pp. 2095​-2098​.​ DOI: https://doi.org/10.1086/315518 
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• 2000 | Journal Article
  ​ ​Differential expression of sense and antisense transcripts of the mitochondrial DNA region coding for ATPase 6 in fetal and adult porcine brain: Identification of novel unusually assembled mitochondrial RNAs​
  Michel, U.; Stringaris, A. K.; Nau, R. & Rieckmann, P.​ (2000) 
  Biochemical and Biophysical Research Communications, 271(1) pp. 170​-180​.​ DOI: https://doi.org/10.1006/bbrc.2000.2595 
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• 2000 | Journal Article
  ​ ​Release of teichoic and lipoteichoic acids from 30 different strains of Streptococcus pneumoniae during exposure to ceftriaxone, meropenem, quinupristin/dalfopristin, rifampicin and trovafloxacin​
  Heer, C.; Stuertz, K.; Reinert, R. R.; Mader, M. & Nau, R.​ (2000) 
  Infection, 28(1) pp. 13​-20​.​ DOI: https://doi.org/10.1007/s150100050004 
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• 2001 | Journal Article
  ​ ​A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease​
  Gerber, J.; Raivich, G.; Wellmer, A.; Noeske, C.; Kunst, T.; Werner, A. & Bruck, W. W. et al.​ (2001) 
  Acta Neuropathologica, 101(5) pp. 499​-508​.​
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• 2001 | Conference Paper
  ​ ​D- and L-lactate in rabbit and human bacterial meningitis​
  Wellmer, A.; Prange, J.; Gerber, J.; Zysk, G.; Lange, P.; Michel, U. & Eiffert, H. et al.​ (2001)
  Scandinavian Journal of Infectious Diseases, 33(12) pp. 909​-913. ​40th Interscience Conference on Antimicrobial Agents and Chemotherapy​, TORONTO, CANADA.
  Oslo​: Taylor & Francis As.
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• 2001 | Journal Article
  ​ ​Reduced release of DNA from Streptococcus pneumoniae after treatment with rifampin in comparison to spontaneous growth and ceftriaxone treatment​
  Gerber, J.; Eiffert, H.; Fleischer, H.; Wellmer, A.; Munzel, U. & Nau, R.​ (2001) 
  European Journal of Clinical Microbiology & Infectious Diseases, 20(7) pp. 490​-493​.​
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• 2001 | Journal Article
  ​ ​Organotypic hippocampal cultures A model of brain tissue damage in Streptococcus pneumoniae meningitis​
  Schmidt, H.; Tlustochowska, A.; Stuertz, K.; Djukic, M.; Gerber, J.; Schutz, E. & Kuhnt, U. et al.​ (2001) 
  Journal of Neuroimmunology, 113(1) pp. 30​-39​.​ DOI: https://doi.org/10.1016/S0165-5728(00)00402-1 
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• 2001 | Journal Article
  ​ ​The cell wall-associated serine protease PrtA: a highly conserved virulence factor of Streptococcus pneumoniae​
  Bethe, G.; Nau, R.; Wellmer, A.; Hakenbeck, R.; Reinert, R. R.; Heinz, H. P. & Zysk, G.​ (2001) 
  FEMS Microbiology Letters, 205(1) pp. 99​-104​.​ DOI: https://doi.org/10.1111/j.1574-6968.2001.tb10931.x 
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• 2001 | Journal Article
  ​ ​Activity of LY333328 in experimental meningitis caused by a Streptococcus pneumoniae strain susceptible to penicillin​
  Gerber, J.; Smirnov, A.; Wellmer, A.; Ragheb, J.; Prange, J.; Schutz, E. & Wettich, K. et al.​ (2001) 
  Antimicrobial Agents and Chemotherapy, 45(7) pp. 2169​-2172​.​ DOI: https://doi.org/10.1128/AAC.45.7.2169-2172.2001 
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• 2001 | Journal Article
  ​ ​Effect of deficiency of tumor necrosis factor alpha or both of its receptors on Streptococcus pneumoniae central nervous system infection and peritonitis​
  Wellmer, A.; Gerber, J.; Ragheb, J.; Zysk, G.; Kunst, T.; Smirnov, A. & Bruck, W. W. et al.​ (2001) 
  Infection and Immunity, 69(11) pp. 6881​-6886​.​ DOI: https://doi.org/10.1128/IAI.69.11.6881-6886.2001 
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• 2002 | Journal Article
  ​ ​Neuronal apoptosis in the denate gyrus in humans with subarachnoid hemorrage and cerebral hypoxia​
  Nau, R.; Haase, S.; Bunkowski, S. & Bruck, W. W.​ (2002) 
  Brain Pathology, 12(3) pp. 329​-336​.​
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• 2002 | Journal Article
  ​ ​Protein synthesis inhibiting clindamycin improves outcome in a mouse model of Staphylococcus aureus sepsis compared with the cell wall active ceftriaxone​
  Azeh, I.; Gerber, J.; Wellmer, A.; Wellhausen, M.; Koenig, B.; Eiffert, H. & Nau, R.​ (2002) 
  Critical Care Medicine, 30(7) pp. 1560​-1564​.​ DOI: https://doi.org/10.1097/00003246-200207000-00027 
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• 2002 | Review
  ​ ​Modulation of release of proinflammatory bacterial compounds by antibacterials: Potential impact on course of inflammation and outcome in sepsis and meningitis​
  Nau, R.& Eiffert, H.​ (2002)
  Clinical Microbiology Reviews, 15​(1) pp. 95​-+​.​
  Amer Soc Microbiology. DOI: https://doi.org/10.1128/CMR.15.1.95-110.2002 
  ​Details  DOI  PMID  PMC  WoS 

• 2002 | Review
  ​ ​Neuronal injury in bacterial meningitis: mechanisms and implications for therapy​
  Nau, R.& Bruck, W. W.​ (2002)
  Trends in Neurosciences, 25​(1) pp. 38​-45​.​
  Elsevier Science London. DOI: https://doi.org/10.1016/S0166-2236(00)02024-5 
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• 2002 | Journal Article
  ​ ​Decreased virulence of a pneumolysin-deficient strain of Streptococcus pneumoniae in murine meningitis​
  Wellmer, A.; Zysk, G.; Gerber, J.; Kunst, T.; von Mering, M.; Bunkowski, S. & Eiffert, H. et al.​ (2002) 
  Infection and Immunity, 70(11) pp. 6504​-6508​.​ DOI: https://doi.org/10.1128/IAI.70.11.6504-6508.2002 
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• 2003 | Journal Article | Letter Note
  ​ ​Pathophysiology of neuronal injury in bacterial meningitis: concepts and implications​
  Nau, R.​ (2003) 
  Neurología, 18(2) pp. 47​-53​.​
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• 2003 | Journal Article
  ​ ​Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9)​
  Iliev, A. I.; Stringaris, A. K.; Nau, R. & Neumann, H.​ (2003) 
  The FASEB Journal, 17(15) pp. 412​-+​.​ DOI: https://doi.org/10.1096/fj.03-0670fje 
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• 2003 | Journal Article
  ​ ​Polyneuropathy as a sole syndrome in mialignant thymoma​
  Schmidt, H.; Kaboth, U.; Brinck, U.; Ratzka, P.; Rustenbeck, H. H. & Nau, R.​ (2003) 
  Der Nervenarzt, 74(10) pp. 888​-+​.​ DOI: https://doi.org/10.1007/s00115-003-1552-z 
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• 2003 | Journal Article
  ​ ​Increased activin levels in cerebrospinal fluid of rabbits with bacterial meningitis are associated with activation of microglia​
  Michel, U.; Gerber, J.; O'Connor, A. E.; Bunkowski, S.; Bruck, W. W.; Nau, R. & Phillips, D. J.​ (2003) 
  Journal of Neurochemistry, 86(1) pp. 238​-245​.​ DOI: https://doi.org/10.1046/j.1471-4159.2003.01834.x 
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• 2003 | Conference Paper
  ​ ​Regional differences in glutamine synthetase inhibition by L-methionine sulfoximine: a microdialysis study in the rabbit brain​
  Bottcher, T.; Goiny, M.; Bering, J.; Domhof, S.; Nau, R. & Ungerstedt, U.​ (2003)
  Experimental Brain Research, 150(2) pp. 194​-200. ​12th Meeting of the European-Neurological-Society (ENS)​, BERLIN, GERMANY.
  New york​: Springer. DOI: https://doi.org/10.1007/s00221-003-1401-0 
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• 2003 | Journal Article
  ​ ​Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone​
  Spreer, A.; Kerstan, H.; Bottcher, T.; Gerber, J.; Siemer, A.; Zysk, G. & Mitchell, T. J. et al.​ (2003) 
  Antimicrobial Agents and Chemotherapy, 47(8) pp. 2649​-2654​.​ DOI: https://doi.org/10.1128/AAC.47.8.2649-2654.2003 
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• 2003 | Journal Article
  ​ ​Rifampin followed by ceftriaxone for experimental meningitis decreases lipoteichoic acid concentrations in cerebrospinal fluid and reduces neuronal damage in comparison to ceftriaxone alone​
  Gerber, J.; Pohl, K.; Sander, V.; Bunkowski, S. & Nau, R.​ (2003) 
  Antimicrobial Agents and Chemotherapy, 47(4) pp. 1313​-1317​.​ DOI: https://doi.org/10.1128/AAC.47.4.1313-1317.2003 
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• 2003 | Journal Article
  ​ ​Increased neurogenesis after experimental Streptococcus pneumoniae meningitis​
  Gerber, J.; Bottcher, T.; Bering, J.; Bunkowski, S.; Bruck, W. W.; Kuhnt, U. & Nau, R.​ (2003) 
  Journal of Neuroscience Research, 73(4) pp. 441​-446​.​ DOI: https://doi.org/10.1002/jnr.10682 
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• 2003 | Journal Article
  ​ ​Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia​
  Michel, U.; Ebert, S.; Phillips, D. & Nau, R.​ (2003) 
  European Journal of Endocrinology, 148(5) pp. 559​-564​.​ DOI: https://doi.org/10.1530/eje.0.1480559 
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• 2003 | Journal Article
  ​ ​Matrix metalloproteinase-9 deficiency impairs host defense mechanisms against Streptococcus pneumoniae in a mouse model of bacterial meningitis​
  Bottcher, T.; Spreer, A.; Azeh, I.; Nau, R. & Gerber, J.​ (2003) 
  Neuroscience Letters, 338(3) pp. 201​-204​.​ DOI: https://doi.org/10.1016/S0304-3940(02)01406-4 
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• 2003 | Journal Article
  ​ ​Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections​
  Bottcher, T.; von Mering, M.; Ebert, S.; Meyding-Lamade, U.; Kuhnt, U.; Gerber, J. & Nau, R.​ (2003) 
  Neuroscience Letters, 344(1) pp. 17​-20​.​ DOI: https://doi.org/10.1016/S0304-3940(03)00404-X 
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• 2003 | Journal Article
  ​ ​Deep cerebral venous sinus thrombosis often presents with neuropsychologic symptoms​
  von Mering, M.; Stiefel, M.; Brockmann, K. & Nau, R.​ (2003) 
  Journal of Clinical Neuroscience, 10(3) pp. 310​-312​.​ DOI: https://doi.org/10.1016/S0967-5868(03)00017-1 
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• 2004 | Review
  ​ ​Therapy of bacterial meningitis​
  Schmidt, H.& Nau, R.​ (2004)
  AKTUELLE NEUROLOGIE, 31​(5) pp. 231​-240​.​
  Georg Thieme Verlag Kg. DOI: https://doi.org/10.1055/s-2003-814936 
  ​Details  DOI  WoS 

• 2004 | Conference Abstract
  ​ ​PavA of Streptococcus pneumoniae: a modulator of invasion and meningeal inflammation​
  Pracht, D.; Elm, C.; Gerber, J.; Jenkinson, H. F.; Nau, R. & Hammerschmidt, S.​ (2004)
  International Journal of Medical Microbiology, 294 pp. 87​-88. ​Annual Meeting of the DGHM​, Munster, GERMANY.
  Jena​: Urban & Fischer Verlag.
  ​Details  WoS 

• 2004 | Journal Article
  ​ ​Axonal injury, a neglected cause of CNS damage in bacterial meningitis​
  Nau, R.; Gerber, J.; Bunkowski, S. & Bruck, W. W.​ (2004) 
  Neurology, 62(3) pp. 509​-511​.​
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• 2004 | Journal Article
  ​ ​Increased mortality and spatial memory deficits in TNF-alpha-deficient mice in ceftriaxone-treated experimental pneumococcal meningitis​
  Gerber, J.; Bottcher, T.; Hahn, M.; Siemer, A.; Bunkowski, S. & Nau, R.​ (2004) 
  Neurobiology of Disease, 16(1) pp. 133​-138​.​ DOI: https://doi.org/10.1016/j.nbd.2004.01.013 
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• 2004 | Journal Article
  ​ ​Differences in clinical manifestation of Streptococcus pneumoniae infection are not correlated with in vitro production and release of the virulence factors pneumolysin and lipoteichoic and teichoic acids​
  Spreer, A.; Lis, A.; Gerber, J.; Reinert, R. R.; Eiffert, H. & Nau, R.​ (2004) 
  Journal of Clinical Microbiology, 42(7) pp. 3342​-3345​.​ DOI: https://doi.org/10.1128/JCM.42.7.3342-3345.2004 
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• 2004 | Journal Article
  ​ ​Experimental pneumococcal meningitis: Impaired clearance of bacteria from the blood due to increased apoptosis in the spleen in Bcl-2-deficient mice​
  Wellmer, A.; von Mering, M.; Spreer, A.; Diem, R.; Eiffert, H.; Noeske, C. & Bunkowski, S. et al.​ (2004) 
  Infection and Immunity, 72(6) pp. 3113​-3119​.​ DOI: https://doi.org/10.1128/IAI.72.6.3113-3119.2004 
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• 2005 | Journal Article
  ​ ​PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation​
  Pracht, D.; Elm, C.; Gerber, J.; Bergmann, S.; Rohde, M.; Seiler, M. & Kim, K. S. et al.​ (2005) 
  Infection and Immunity, 73(5) pp. 2680​-2689​.​ DOI: https://doi.org/10.1128/IAI.73.5.2680-2689.2005 
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• 2005 | Journal Article
  ​ ​Moxifloxacin in experimental Streptococcus pneumoniae cerebritis and meningitis​
  Djukic, M.; Bottcher, T.; Wellmer, A.; Gerber, J.; Brocke, V. V.; Eiffert, H. & Nau, R.​ (2005) 
  Neurocritical Care, 2(3) pp. 325​-329​.​ DOI: https://doi.org/10.1385/NCC:2:3:325 
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• 2005 | Review
  ​ ​Minimizing the release of proinflammatory and toxic bacterial products within the host: A promising approach to improve outcome in life-threatening infections​
  Nau, R.& Eiffert, H.​ (2005)
  FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 44​(1) pp. 1​-16​.​
  Elsevier Science Bv. DOI: https://doi.org/10.1016/j.femsim.2005.01.001 
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• 2005 | Journal Article
  ​ ​Melatonin is neuroprotective in experimental Streptococcus pneumoniae meningitis​
  Gerber, J.; Lotz, M.; Ebert, S.; Kiel, S.; Huether, G.; Kuhnt, U. & Nau, R.​ (2005) 
  The Journal of Infectious Diseases, 191(5) pp. 783​-790​.​ DOI: https://doi.org/10.1086/427816 
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• 2005 | Journal Article
  ​ ​Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures​
  Lotz, M.; Ebert, S.; Esselmann, H.; Iliev, A. I.; Prinz, M. R.; Wiazewicz, N. & Wiltfang, J. et al.​ (2005) 
  Journal of Neurochemistry, 94(2) pp. 289​-298​.​ DOI: https://doi.org/10.1111/j.1471-4159.2005.03188.x 
  ​Details  DOI  PMID  PMC  WoS 

• 2005 | Journal Article
  ​ ​Increased expression of BDNF and proliferation of dentate granule cells after bacterial meningitis​
  Tauber, S. C.; Stadelmann, C. ; Spreer, A.; Bruck, W. W.; Nau, R. & Gerber, J.​ (2005) 
  Journal of Neuropathology & Experimental Neurology, 64(9) pp. 806​-815​.​ DOI: https://doi.org/10.1097/01.jnen.0000178853.21799.88 
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• 2005 | Journal Article
  ​ ​Pharmacodynamics of antibiotics with respect to bacterial killing of and release of lipoteichoic acid by Streptococcus pneumoniae​
  Mattie, H.; Stuertz, K.; Nau, R. & van Dissel, J. T.​ (2005) 
  Journal of Antimicrobial Chemotherapy, 56(1) pp. 154​-159​.​ DOI: https://doi.org/10.1093/jac/dki176 
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• 2005 | Journal Article
  ​ ​Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination​
  Ebert, S.; Gerber, J.; Bader, S.; Muhlhauser, F.; Brechtel, K.; Mitchell, T. J. & Nau, R.​ (2005) 
  Journal of Neuroimmunology, 159(1-2) pp. 87​-96​.​ DOI: https://doi.org/10.1016/j.jneuroim.2004.10.005 
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• 2006 | Conference Abstract
  ​ ​Bone marrow-derived monocytes/macrophages migrate into the cental nervous system and differentiate to microglia after Streptococcus pneumoniae meningitis in mice​
  Djukic, M.; Mildner, A.; Schmidt, H.; Czesnik, D.; Brueck, W.; Priller, J. & Nau, R. et al.​ (2006)
  Journal of Neurology, 253 pp. 53​-54. ​16th Annual Meeting of the European-Neurological-Society​, Lausanne, SWITZERLAND.
  Darmstadt​: Dr Dietrich Steinkopff Verlag.
  ​Details  WoS 

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