Author Hoffmann, Markus

1 to 50 of 111 Items
  • 2011 Journal Article
    ​ ​Comparative Analysis of Ebola Virus Glycoprotein Interactions With Human and Bat Cells​
    Kühl, A.; Hoffmann, M.; Müller, M. A.; Munster, V. J.; Gnirß, K.; Kiene, M. & Tsegaye, T. S. et al.​ (2011) 
    The Journal of Infectious Diseases204(suppl_3) pp. S840​-S849​.​ DOI: https://doi.org/10.1093/infdis/jir306 
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  • 2015 Journal Article
    ​ ​Interferon-Induced Transmembrane Protein–Mediated Inhibition of Host Cell Entry of Ebolaviruses​
    Wrensch, F.; Karsten, C. B.; Gnirß, K.; Hoffmann, M.; Lu, K.; Takada, A. & Winkler, M. et al.​ (2015) 
    Journal of Infectious Diseases212(suppl 2) pp. S210​-S218​.​ DOI: https://doi.org/10.1093/infdis/jiv255 
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  • 2016 Journal Article
    ​ ​Recombinant mumps viruses expressing the batMuV fusion glycoprotein are highly fusion active and neurovirulent​
    Krüger, N.; Sauder, C.; Hoffmann, M.; Örvell, C.; Drexler, J. F.; Rubin, S. & Herrler, G.​ (2016) 
    Journal of General Virology97(11) pp. 2837​-2848​.​ DOI: https://doi.org/10.1099/jgv.0.000596 
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  • 2016 Journal Article
    ​ ​The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies​
    Brinkmann, C.; Nehlmeier, I.; Walendy-Gnirß, K.; Nehls, J.; González Hernández, M.; Hoffmann, M. & Qiu, X. et al.​ (2016) 
    Journal of Virology90(24) pp. 11075​-11086​.​ DOI: https://doi.org/10.1128/JVI.01563-16 
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  • 2016 Journal Article | 
    ​ ​The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent.​
    Hoffmann, M.; González Hernández, M.; Berger, E.; Marzi, A. & Pöhlmann, S.​ (2016) 
    PloS one11(2) art. e0149651​.​ DOI: https://doi.org/10.1371/journal.pone.0149651 
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  • 2016 Journal Article | 
    ​ ​The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells.​
    Hoffmann, M.; Krüger, N.; Zmora, P.; Wrensch, F.; Herrler, G. & Pöhlmann, S.​ (2016) 
    PloS one11(3) art. e0152134​.​ DOI: https://doi.org/10.1371/journal.pone.0152134 
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  • 2017 Journal Article
    ​ ​A Polymorphism within the Internal Fusion Loop of the Ebola Virus Glycoprotein Modulates Host Cell Entry​
    Hoffmann, M.; Crone, L.; Dietzel, E.; Paijo, J.; González-Hernández, M.; Nehlmeier, I. & Kalinke, U. et al.​ (2017) 
    Journal of Virology91(9) art. e00177-17​.​ DOI: https://doi.org/10.1128/JVI.00177-17 
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  • 2017 Journal Article
    ​ ​Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins​
    Wrensch, F.; Hoffmann, M.; Gärtner, S.; Nehlmeier, I.; Winkler, M. & Pöhlmann, S.​ (2017) 
    Journal of Virology91(2) art. e01488-16​.​ DOI: https://doi.org/10.1128/JVI.01488-16 
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  • 2017 Journal Article | Research Paper | 
    ​ ​The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells​
    Brinkmann, C.; Hoffmann, M.; Lübke, A.; Nehlmeier, I.; Krämer-Kühl, A.; Winkler, M.   & Pöhlmann, S. ​ (2017) 
    PLoS One12(12) art. e0189073​.​ DOI: https://doi.org/10.1371/journal.pone.0189073 
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  • 2017 Journal Article | 
    ​ ​Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2.​
    Reinke, L. M.; Spiegel, M.; Plegge, T.; Hartleib, A.; Nehlmeier, I.; Gierer, S. & Hoffmann, M. et al.​ (2017) 
    PloS one12(6) art. e0179177​.​ DOI: https://doi.org/10.1371/journal.pone.0179177 
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  • 2018 Journal Article
    ​ ​TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1​
    Zmora, P.; Hoffmann, M.; Kollmus, H.; Moldenhauer, A.-S.; Danov, O.; Braun, A. & Winkler, M.  et al.​ (2018) 
    Journal of Biological Chemistry293(36) pp. 13863​-13873​.​ DOI: https://doi.org/10.1074/jbc.RA118.001273 
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  • 2018 Journal Article
    ​ ​A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism​
    González-Hernández, M.; Hoffmann, M.; Brinkmann, C.; Nehls, J.; Winkler, M.; Schindler, M. & Pöhlmann, S.​ (2018) 
    Journal of Virology92(13) art. e00403-18​.​ DOI: https://doi.org/10.1128/JVI.00403-18 
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  • 2018 Journal Article
    ​ ​Cell Entry of Influenza A Viruses: Sweet Talk between HA and CaV1.2​
    Hoffmann, M. & Pöhlmann, S.​ (2018) 
    Cell Host & Microbe23(6) pp. 697​-699​.​ DOI: https://doi.org/10.1016/j.chom.2018.05.019 
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  • 2018 Journal Article
    ​ ​Entry, Replication, Immune Evasion, and Neurotoxicity of Synthetically Engineered Bat-Borne Mumps Virus​
    Krüger, N.; Sauder, C.; Hüttl, S.; Papies, J.; Voigt, K.; Herrler, G. & Hardes, K. et al.​ (2018) 
    Cell Reports25(2) pp. 312​-320.e7​.​ DOI: https://doi.org/10.1016/j.celrep.2018.09.018 
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  • 2018 Journal Article | 
    ​ ​Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein​
    Kleine-Weber, H.; Elzayat, M. T.; Hoffmann, M. & Pöhlmann, S. ​ (2018) 
    Scientific Reports8(1) art. 16597​.​ DOI: https://doi.org/10.1038/s41598-018-34859-w 
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  • 2019 Journal Article
    ​ ​Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L​
    González-Hernández, M.; Müller, A.; Hoenen, T.; Hoffmann, M. & Pöhlmann, S. ​ (2019) 
    Virology532 pp. 22​-29​.​ DOI: https://doi.org/10.1016/j.virol.2019.03.020 
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  • 2019 Journal Article
    ​ ​Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization​
    Kleine-Weber, H.; Elzayat, M. T.; Wang, L.; Graham, B. S.; Müller, M. A.; Drosten, C. & Pöhlmann, S.  et al.​ (2019) 
    Journal of Virology93(2).​ DOI: https://doi.org/10.1128/JVI.01381-18 
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  • 2019 Journal Article
    ​ ​Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells​
    Hoffmann, M.; Nehlmeier, I.; Brinkmann, C.; Krähling, V.; Behner, L.; Moldenhauer, A.-S. & Krüger, N. et al.​ (2019) 
    Journal of Virology93(3).​ DOI: https://doi.org/10.1128/JVI.01821-18 
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  • 2019 Journal Article
    ​ ​Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner​
    Nehls, J.; Businger, R.; Hoffmann, M.; Brinkmann, C.; Fehrenbacher, B.; Schaller, M. & Maurer, B. et al.​ (2019) 
    Cell Reports26(7) pp. 1841​-1853.e6​.​ DOI: https://doi.org/10.1016/j.celrep.2019.01.065 
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  • 2019 Journal Article
    ​ ​Spike proteins of novel MERS-coronavirus isolates from North- and West-African dromedary camels mediate robust viral entry into human target cells​
    Kleine-Weber, H.; Pöhlmann, S.   & Hoffmann, M.​ (2019) 
    Virology535 pp. 261​-265​.​ DOI: https://doi.org/10.1016/j.virol.2019.07.016 
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  • 2019 Journal Article | 
    ​ ​Disease Manifestation and Viral Sequences in a Bonobo More Than 30 Years after Papillomavirus Infection​
    Hoffmann, M.; Schütze, E.; Bernhard, A. ; Schlaphoff, L.; Kaul, A.; Schöniger, S. & Pöhlmann, S. ​ (2019) 
    Pathogens8(1) pp. 13​.​ DOI: https://doi.org/10.3390/pathogens8010013 
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  • 2019 Journal Article | 
    ​ ​Analysis of Resistance of Ebola Virus Glycoprotein-Driven Entry Against MDL28170, An Inhibitor of Cysteine Cathepsins​
    Hoffmann, M.; Kaufmann, S. V.; Fischer, C.; Maurer, W.; Moldenhauer, A.-S. & Pöhlmann, S. ​ (2019) 
    Pathogens8(4) pp. 192​.​ DOI: https://doi.org/10.3390/pathogens8040192 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Fusogenicity of the Ghana Virus (Henipavirus: Ghanaian bat henipavirus) Fusion Protein is Controlled by the Cytoplasmic Domain of the Attachment Glycoprotein​
    Voigt, K.; Hoffmann, M.; Drexler, J. F.; Müller, M. A.; Drosten, C.; Herrler, G. & Krüger, N.​ (2019) 
    Viruses11(9) art. 800​.​ DOI: https://doi.org/10.3390/v11090800 
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  • 2019 Journal Article | 
    ​ ​Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance​
    Korniy, N.; Goyal, A. ; Hoffmann, M.; Samatova, E. ; Peske, F. ; Pöhlmann, S.   & Rodnina, M. V ​ (2019) 
    Nucleic Acids Research47(10) pp. 5210​-5222​.​ DOI: https://doi.org/10.1093/nar/gkz202 
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  • 2019 Journal Article | 
    ​ ​Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques​
    Winkler, M. ; Gärtner, S.; Markus, L.; Hoffmann, M.; Nehlmeier, I.; Krawczak, M.   & Sauermann, U. et al.​ (2019) 
    PLoS One14(11) art. e0224082​.​ DOI: https://doi.org/10.1371/journal.pone.0224082 
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  • 2019 Journal Article | 
    ​ ​A system for production of defective interfering particles in the absence of infectious influenza A virus​
    Bdeir, N.; Arora, P.; Gärtner, S.; Hoffmann, M.; Reichl, U.; Pöhlmann, S. & Winkler, M.​ (2019) 
    PlOS ONE14(3) art. e0212757​.​ DOI: https://doi.org/10.1371/journal.pone.0212757 
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  • 2020 Journal Article
    ​ ​Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus​
    Kleine-Weber, H.; Schroeder, S.; Krüger, N.; Prokscha, A.; Naim, H. Y.; Müller, M. A. & Drosten, C. et al.​ (2020) 
    Emerging Microbes & Infections9(1) pp. 155​-168​.​ DOI: https://doi.org/10.1080/22221751.2020.1713705 
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  • 2020 Journal Article
    ​ ​Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19​
    Hoffmann, M.; Schroeder, S.; Kleine-Weber, H.; Müller, M. A.; Drosten, C. & Pöhlmann, S. ​ (2020) 
    Antimicrobial Agents and Chemotherapy64(6).​ DOI: https://doi.org/10.1128/AAC.00754-20 
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  • 2020 Journal Article
    ​ ​A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells​
    Hoffmann, M.; Kleine-Weber, H. & Pöhlmann, S. ​ (2020) 
    Molecular Cell78(4) pp. 779​-784.e5​.​ DOI: https://doi.org/10.1016/j.molcel.2020.04.022 
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  • 2020 Journal Article
    ​ ​Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies​
    Wrapp, D.; De Vlieger, D.; Corbett, K. S.; Torres, G. M.; Wang, N.; Van Breedam, W. & Roose, K. et al.​ (2020) 
    Cell181(5) pp. 1004​-1015.e15​.​ DOI: https://doi.org/10.1016/j.cell.2020.04.031 
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  • 2020 Journal Article
    ​ ​The Amino Acid at Position 8 of the Proteolytic Cleavage Site of the Mumps Virus Fusion Protein Affects Viral Proteolysis and Fusogenicity​
    Hüttl, S.; Hoffmann, M.; Steinmetzer, T.; Sauder, C. & Krüger, N.​ (2020) 
    Journal of Virology94(22).​ DOI: https://doi.org/10.1128/JVI.01732-20 
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  • 2020 Journal Article
    ​ ​Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2​
    Edwards, M. J.; Becker, K. A.; Gripp, B.; Hoffmann, M.; Keitsch, S.; Wilker, B. & Soddemann, M. et al.​ (2020) 
    Journal of Biological Chemistry295(45) pp. 15174​-15182​.​ DOI: https://doi.org/10.1074/jbc.RA120.015249 
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  • 2020 Journal Article
    ​ ​Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases​
    Haskamp, S.; Bruns, H.; Hahn, M.; Hoffmann, M.; Gregor, A.; Löhr, S. & Hahn, J. et al.​ (2020) 
    The American Journal of Human Genetics107(3) pp. 527​-538​.​ DOI: https://doi.org/10.1016/j.ajhg.2020.07.001 
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  • 2020 Journal Article
    ​ ​SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor​
    Hoffmann, M.; Kleine-Weber, H.; Schroeder, S.; Krüger, N.; Herrler, T.; Erichsen, S. & Schiergens, T. S. et al.​ (2020) 
    Cell181(2) pp. 271​-280.e8​.​ DOI: https://doi.org/10.1016/j.cell.2020.02.052 
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  • 2020 Journal Article | Research Paper | 
    ​ ​Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells​
    Carpinteiro, A.; Edwards, M. J.; Hoffmann, M.; Kochs, G.; Gripp, B.; Weigang, S. & Adams, C. et al.​ (2020) 
    Cell Reports. Medicine1(8) pp. 100142​.​ DOI: https://doi.org/10.1016/j.xcrm.2020.100142 
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  • 2020 Journal Article | 
    ​ ​Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2​
    Lapuente, D.; Maier, C.; Irrgang, P.; Hübner, J.; Peter, A. S.; Hoffmann, M. & Ensser, A. et al.​ (2020) 
    European Journal of Clinical Microbiology & Infectious Diseases40(4) pp. 751​-759​.​ DOI: https://doi.org/10.1007/s10096-020-04072-7 
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  • 2020 Journal Article | 
    ​ ​LY6E impairs coronavirus fusion and confers immune control of viral disease​
    Pfaender, S.; Mar, K. B.; Michailidis, E.; Kratzel, A.; Boys, I. N.; V’kovski, P. & Fan, W. et al.​ (2020) 
    Nature Microbiology5(11) pp. 1330​-1339​.​ DOI: https://doi.org/10.1038/s41564-020-0769-y 
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  • 2020 Journal Article | 
    ​ ​Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2​
    Hoffmann, M.; Mösbauer, K.; Hofmann-Winkler, H.; Kaul, A.; Kleine-Weber, H.; Krüger, N. & Gassen, N. C. et al.​ (2020) 
    Nature585(7826) pp. 588​-590​.​ DOI: https://doi.org/10.1038/s41586-020-2575-3 
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  • 2020 Journal Article | 
    ​ ​Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods​
    Bošnjak, B.; Stein, S. C.; Willenzon, S.; Cordes, A. K.; Puppe, W.; Bernhardt, G. & Ravens, I. et al.​ (2020) 
    Cellular & Molecular Immunology18(4) pp. 936​-944​.​ DOI: https://doi.org/10.1038/s41423-020-00573-9 
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  • 2021 Journal Article
    ​ ​Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat​
    Hempel, T.; Raich, L.; Olsson, S.; Azouz, N. P.; Klingler, A. M.; Hoffmann, M. & Pöhlmann, S.  et al.​ (2021) 
    Chemical Science12(3) pp. 983​-992​.​ DOI: https://doi.org/10.1039/d0sc05064d 
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  • 2021 Journal Article
    ​ ​Therapeutic Application of alpha-1-antitrypsin in COVID-19​
    Ritzmann, F.; Chitirala, P.; Krüger, N.; Hoffmann, M.; Zuo, W.; Lammert, F. & Smola, S. et al.​ (2021) 
    American Journal of Respiratory and Critical Care Medicine, art. rccm.202104-0833LE​.​ DOI: https://doi.org/10.1164/rccm.202104-0833LE 
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  • 2021 Journal Article
    ​ ​SARS-CoV-2 variant B.1.617 is resistant to bamlanivimab and evades antibodies induced by infection and vaccination​
    Hoffmann, M.; Hofmann-Winkler, H.; Krüger, N.; Kempf, A.; Nehlmeier, I.; Graichen, L. & Arora, P. et al.​ (2021) 
    Cell Reports36(3) art. S2211124721008287​.​ DOI: https://doi.org/10.1016/j.celrep.2021.109415 
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  • 2021 Journal Article
    ​ ​A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells​
    Mahoney, M.; Damalanka, V. C.; Tartell, M. A.; Chung, D. hee; Lourenço, A. L.; Pwee, D. & Mayer Bridwell, A. E. et al.​ (2021) 
    Proceedings of the National Academy of Sciences118(43) pp. e2108728118​.​ DOI: https://doi.org/10.1073/pnas.2108728118 
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  • 2021 Journal Article
    ​ ​SARS-CoV-2 delta variant neutralisation after heterologous ChAdOx1-S/BNT162b2 vaccination​
    Behrens, G. M.; Cossmann, A.; Stankov, M. V; Nehlmeier, I.; Kempf, A.; Hoffmann, M. & Pöhlmann, S.​ (2021) 
    The Lancet398(10305) pp. 1041​-1042​.​ DOI: https://doi.org/10.1016/S0140-6736(21)01891-2 
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  • 2021 Journal Article
    ​ ​B.1.617.2 enters and fuses lung cells with increased efficiency and evades antibodies induced by infection and vaccination​
    Arora, P.; Sidarovich, A.; Krüger, N.; Kempf, A.; Nehlmeier, I.; Graichen, L. & Moldenhauer, A.-S. et al.​ (2021) 
    Cell Reports37(2) art. S2211124721012894​.​ DOI: https://doi.org/10.1016/j.celrep.2021.109825 
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  • 2021 Journal Article
    ​ ​Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells​
    Carpinteiro, A.; Gripp, B.; Hoffmann, M.; Pöhlmann, S. ; Hoertel, N.; Edwards, M. J. & Kamler, M. et al.​ (2021) 
    Journal of Biological Chemistry296 art. S0021925821004907​.​ DOI: https://doi.org/10.1016/j.jbc.2021.100701 
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  • 2021 Journal Article
    ​ ​SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization​
    Hoffmann, M.; Zhang, L.; Krüger, N.; Graichen, L.; Kleine-Weber, H.; Hofmann-Winkler, H. & Kempf, A. et al.​ (2021) 
    Cell Reports35(3) pp. 109017​.​ DOI: https://doi.org/10.1016/j.celrep.2021.109017 
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  • 2021 Journal Article
    ​ ​SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies​
    Hoffmann, M.; Arora, P.; Groß, R.; Seidel, A.; Hörnich, B. F.; Hahn, A. S. & Krüger, N. et al.​ (2021) 
    Cell184(9) pp. 2384​-2393.e12​.​ DOI: https://doi.org/10.1016/j.cell.2021.03.036 
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  • 2021 Journal Article
    ​ ​The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways​
    Laporte, M.; Raeymaekers, V.; Van Berwaer, R.; Vandeput, J.; Marchand-Casas, I.; Thibaut, H.-J. & Van Looveren, D. et al.​ (2021) 
    PLoS Pathogens17(4) pp. e1009500​.​ DOI: https://doi.org/10.1371/journal.ppat.1009500 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity​
    Hoffmann, M.; Hofmann-Winkler, H.; Smith, J. C.; Krüger, N.; Arora, P.; Sørensen, L. K. & Søgaard, O. S. et al.​ (2021) 
    EBioMedicine65 art. 103255​.​ DOI: https://doi.org/10.1016/j.ebiom.2021.103255 
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