Author Hoffmann, Markus

• 2019 | Journal Article | 
  ​ ​Disease Manifestation and Viral Sequences in a Bonobo More Than 30 Years after Papillomavirus Infection​
  Hoffmann, M.; Schütze, E.; Bernhard, A. ; Schlaphoff, L.; Kaul, A.; Schöniger, S. & Pöhlmann, S. ​ (2019) 
  Pathogens, 8(1) pp. 13​.​ DOI: https://doi.org/10.3390/pathogens8010013 
  ​Details  DOI 

• 2019 | Journal Article | 
  ​ ​Analysis of Resistance of Ebola Virus Glycoprotein-Driven Entry Against MDL28170, An Inhibitor of Cysteine Cathepsins​
  Hoffmann, M.; Kaufmann, S. V.; Fischer, C.; Maurer, W.; Moldenhauer, A.-S. & Pöhlmann, S. ​ (2019) 
  Pathogens, 8(4) pp. 192​.​ DOI: https://doi.org/10.3390/pathogens8040192 
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• 2019 | Journal Article | 
  ​ ​Fusogenicity of the Ghana Virus (Henipavirus: Ghanaian bat henipavirus) Fusion Protein is Controlled by the Cytoplasmic Domain of the Attachment Glycoprotein​
  Voigt, K.; Hoffmann, M.; Drexler, J. F.; Müller, M. A.; Drosten, C.; Herrler, G. & Krüger, N.​ (2019) 
  Viruses, 11(9) art. 800​.​ DOI: https://doi.org/10.3390/v11090800 
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• 2019 | Journal Article | 
  ​ ​Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance​
  Korniy, N.; Goyal, A. ; Hoffmann, M.; Samatova, E. ; Peske, F. ; Pöhlmann, S.   & Rodnina, M. V ​ (2019) 
  Nucleic Acids Research, 47(10) pp. 5210​-5222​.​ DOI: https://doi.org/10.1093/nar/gkz202 
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• 2019 | Journal Article | 
  ​ ​Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques​
  Winkler, M. ; Gärtner, S.; Markus, L.; Hoffmann, M.; Nehlmeier, I.; Krawczak, M.   & Sauermann, U. et al.​ (2019) 
  PLoS One, 14(11) art. e0224082​.​ DOI: https://doi.org/10.1371/journal.pone.0224082 
  ​Details  DOI  PMID  PMC 

• 2019 | Journal Article | 
  ​ ​A system for production of defective interfering particles in the absence of infectious influenza A virus​
  Bdeir, N.; Arora, P.; Gärtner, S.; Hoffmann, M.; Reichl, U.; Pöhlmann, S. & Winkler, M.​ (2019) 
  PlOS ONE, 14(3) art. e0212757​.​ DOI: https://doi.org/10.1371/journal.pone.0212757 
  ​Details  DOI  PMID  PMC 

• 2020 | Journal Article
  ​ ​Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus​
  Kleine-Weber, H.; Schroeder, S.; Krüger, N.; Prokscha, A.; Naim, H. Y.; Müller, M. A. & Drosten, C. et al.​ (2020) 
  Emerging Microbes & Infections, 9(1) pp. 155​-168​.​ DOI: https://doi.org/10.1080/22221751.2020.1713705 
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• 2020 | Journal Article
  ​ ​Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19​
  Hoffmann, M.; Schroeder, S.; Kleine-Weber, H.; Müller, M. A.; Drosten, C. & Pöhlmann, S. ​ (2020) 
  Antimicrobial Agents and Chemotherapy, 64(6).​ DOI: https://doi.org/10.1128/AAC.00754-20 
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• 2020 | Journal Article
  ​ ​A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells​
  Hoffmann, M.; Kleine-Weber, H. & Pöhlmann, S. ​ (2020) 
  Molecular Cell, 78(4) pp. 779​-784.e5​.​ DOI: https://doi.org/10.1016/j.molcel.2020.04.022 
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• 2020 | Journal Article
  ​ ​Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies​
  Wrapp, D.; De Vlieger, D.; Corbett, K. S.; Torres, G. M.; Wang, N.; Van Breedam, W. & Roose, K. et al.​ (2020) 
  Cell, 181(5) pp. 1004​-1015.e15​.​ DOI: https://doi.org/10.1016/j.cell.2020.04.031 
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• 2020 | Journal Article
  ​ ​The Amino Acid at Position 8 of the Proteolytic Cleavage Site of the Mumps Virus Fusion Protein Affects Viral Proteolysis and Fusogenicity​
  Hüttl, S.; Hoffmann, M.; Steinmetzer, T.; Sauder, C. & Krüger, N.​ (2020) 
  Journal of Virology, 94(22).​ DOI: https://doi.org/10.1128/JVI.01732-20 
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• 2020 | Journal Article
  ​ ​Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2​
  Edwards, M. J.; Becker, K. A.; Gripp, B.; Hoffmann, M.; Keitsch, S.; Wilker, B. & Soddemann, M. et al.​ (2020) 
  Journal of Biological Chemistry, 295(45) pp. 15174​-15182​.​ DOI: https://doi.org/10.1074/jbc.RA120.015249 
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• 2020 | Journal Article
  ​ ​Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases​
  Haskamp, S.; Bruns, H.; Hahn, M.; Hoffmann, M.; Gregor, A.; Löhr, S. & Hahn, J. et al.​ (2020) 
  The American Journal of Human Genetics, 107(3) pp. 527​-538​.​ DOI: https://doi.org/10.1016/j.ajhg.2020.07.001 
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• 2020 | Journal Article
  ​ ​SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor​
  Hoffmann, M.; Kleine-Weber, H.; Schroeder, S.; Krüger, N.; Herrler, T.; Erichsen, S. & Schiergens, T. S. et al.​ (2020) 
  Cell, 181(2) pp. 271​-280.e8​.​ DOI: https://doi.org/10.1016/j.cell.2020.02.052 
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• 2020 | Journal Article | Research Paper | 
  ​ ​Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells​
  Carpinteiro, A.; Edwards, M. J.; Hoffmann, M.; Kochs, G.; Gripp, B.; Weigang, S. & Adams, C. et al.​ (2020) 
  Cell Reports. Medicine, 1(8) pp. 100142​.​ DOI: https://doi.org/10.1016/j.xcrm.2020.100142 
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• 2020 | Journal Article | 
  ​ ​Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2​
  Lapuente, D.; Maier, C.; Irrgang, P.; Hübner, J.; Peter, A. S.; Hoffmann, M. & Ensser, A. et al.​ (2020) 
  European Journal of Clinical Microbiology & Infectious Diseases, 40(4) pp. 751​-759​.​ DOI: https://doi.org/10.1007/s10096-020-04072-7 
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• 2020 | Journal Article | 
  ​ ​LY6E impairs coronavirus fusion and confers immune control of viral disease​
  Pfaender, S.; Mar, K. B.; Michailidis, E.; Kratzel, A.; Boys, I. N.; V’kovski, P. & Fan, W. et al.​ (2020) 
  Nature Microbiology, 5(11) pp. 1330​-1339​.​ DOI: https://doi.org/10.1038/s41564-020-0769-y 
  ​Details  DOI 

• 2020 | Journal Article | 
  ​ ​Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2​
  Hoffmann, M.; Mösbauer, K.; Hofmann-Winkler, H.; Kaul, A.; Kleine-Weber, H.; Krüger, N. & Gassen, N. C. et al.​ (2020) 
  Nature, 585(7826) pp. 588​-590​.​ DOI: https://doi.org/10.1038/s41586-020-2575-3 
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• 2020 | Journal Article | 
  ​ ​Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods​
  Bošnjak, B.; Stein, S. C.; Willenzon, S.; Cordes, A. K.; Puppe, W.; Bernhardt, G. & Ravens, I. et al.​ (2020) 
  Cellular & Molecular Immunology, 18(4) pp. 936​-944​.​ DOI: https://doi.org/10.1038/s41423-020-00573-9 
  ​Details  DOI 

• 2021 | Journal Article
  ​ ​Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat​
  Hempel, T.; Raich, L.; Olsson, S.; Azouz, N. P.; Klingler, A. M.; Hoffmann, M. & Pöhlmann, S.  et al.​ (2021) 
  Chemical Science, 12(3) pp. 983​-992​.​ DOI: https://doi.org/10.1039/d0sc05064d 
  ​Details  DOI 

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