Author Knepel, Willhart

1 to 46 of 46 Items

2000 | Review
Heterodimeric Pbx-Prep1 homeodomain protein binding to the glucagon gene restricting transcription in a cell type-dependent manner
Herzig, S.; Fuzesi, L.& Knepel, W. (2000)
Journal of Biological Chemistry, 275(36) pp. 27989-27999.
Amer Soc Biochemistry Molecular Biology Inc.
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2000 | Journal Article
Insulin responsiveness of the glucagon gene conferred by interactions between proximal promoter and more distal enhancer-like elements involving the paired-domain transcription factor Pax6
Grzeskowiak, R.; Amin, J.; Oetjen, E. & Knepel, W. (2000)
Journal of Biological Chemistry, 275(39) pp. 30037-30045. DOI: https://doi.org/10.1074/jbc.M000984200
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2001 | Conference Abstract
PPAR gamma-mediated inhibition of glucagon gene transcription by the oral antidiabetic agents thiazolidinediones
Schinner, S.; Dellas, C.; Heinlein, C.; Chang, C. & Knepel, W. (2001)
Naunyn-Schmiedeberg s Archives of Pharmacology, 363(4)
New york: Springer.
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2001 | Conference Abstract
Effect of the dual leucine zipper bearing kinase on membrane-depolarization-stimulated CRE/CREB-dependent transcription
Oetjen, E.; Lechleiter, A.; Blume, R.; Nihalani, D.; Holzman, L. & Knepel, W. (2001)
Naunyn-Schmiedeberg s Archives of Pharmacology, 363(4)
New york: Springer.
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2002 | Conference Abstract
Effect of antidepressant drugs and psychosocial stress on cAMP response element dependent reporter gene expression in the brain of transgenic mice
Alejel, T.; Beimesche, S.; Cierny, I.; Krause, D. & Knepel, W. (2002)
Naunyn-Schmiedeberg s Archives of Pharmacology, 365
New york: Springer.
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2002 | Conference Abstract
Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in a pancreatic beta-cell line and in primary mature pancreatic islets of transgenic mice
Oetjen, E.; Grapentin, D.; Baun, D.; Blume, R.; Krause, D.; Beimesche, S. & Cierny, I. et al. (2002)
Naunyn-Schmiedeberg s Archives of Pharmacology, 365
New york: Springer.
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2002 | Journal Article
Repression of glucagon gene transcription by peroxisome proliferator-activated receptor gamma through inhibition of Pax6 transcriptional activity
Schinner, S.; Dellas, C.; Schröder, M.; Heinlein, C. A.; Chang, C. S.; Fischer, J. & Knepel, W. (2002)
Journal of Biological Chemistry, 277(3) pp. 1941-1948. DOI: https://doi.org/10.1074/jbc.M109718200
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2003 | Conference Abstract
Regulation of glucagon gene transcription by insulin: Role of glycogen synthase kinase 3
Dimopoulos, N. & Knepel, W. (2003)
Naunyn-Schmiedeberg s Archives of Pharmacology, 367 44th Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie/20th Gesellschaft-fur-Umwelt-Mutationsforschung, MAINZ, GERMANY.
New york: Springer.
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2003 | Conference Abstract
The thiazolidinedione-binding nuclear receptor PPAR gamma mediates inhibition of glucagon gene transcription as a heterodimer with
Lepler, K.; Schinner, S. & Knepel, W. (2003)
Naunyn-Schmiedeberg s Archives of Pharmacology, 367 44th Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie/20th Gesellschaft-fur-Umwelt-Mutationsforschung, MAINZ, GERMANY.
New york: Springer.
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2003 | Conference Abstract
The map kinase kinase kinase 1 inhibits CREB transcriptional activity stimulated by cyclic amp and membrane depolarization
Oetjen, E.; Grandke, G.; Blume, R. & Knepel, W. (2003)
Naunyn-Schmiedeberg s Archives of Pharmacology, 367 44th Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie/20th Gesellschaft-fur-Umwelt-Mutationsforschung, MAINZ, GERMANY.
New york: Springer.
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2003 | Journal Article
Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus in primary, mature islets of transgenic mice
Oetjen, E.; Baun, D.; Beimesche, S.; Krause, D.; Cierny, I.; Blume, R. & Dickel, C. et al. (2003)
Molecular Pharmacology, 63(6) pp. 1289-1295. DOI: https://doi.org/10.1124/mol.63.6.1289
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2003 | Journal Article
Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB
Oetjen, E.; Grapentin, D.; Blume, R.; Seeger, M.; Krause, D.; Eggers, A. & Knepel, W. (2003)
Naunyn-Schmiedeberg s Archives of Pharmacology, 367(3) pp. 227-236. DOI: https://doi.org/10.1007/s00210-003-0694-7
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2004 | Conference Abstract
The map kinase kinase kinase I enhances the transcriptional activity of PAX6 and PPAR gamma
Oetjen, E.; Theuner, Y.; Blume, R. & Knepel, W. (2004)
Naunyn-Schmiedeberg s Archives of Pharmacology, 369 45th Spring Meeting of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology, Mainz, GERMANY.
New york: Springer.
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2004 | Conference Abstract
The map kinase kinase kinase 1 does not diminish cylic AMP-induced phosphorylation of CREB on Ser-119
Schlag, C.; Oetjen, E.; Blume, R. & Knepel, W. (2004)
Naunyn-Schmiedeberg s Archives of Pharmacology, 369 45th Spring Meeting of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology, Mainz, GERMANY.
New york: Springer.
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2005 | Conference Abstract
Effect of rosiglitazone and ppar gamma on human insulin gene transcription
Kratzner, R.; Schinner, S.; Schlenczek, S.; Dickel, C. & Knepel, W. (2005)
Naunyn-Schmiedeberg s Archives of Pharmacology, 371 , Mainz, GERMANY.
New york: Springer.
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2005 | Conference Abstract
Chronic but not acute treatment with lithium salts reduces CRE/CREB-directed gene transcription in transgenic reporter gene mice
Boer, U.; Cierny, I.; Krouse, D. & Knepel, W. (2005)
Naunyn-Schmiedeberg s Archives of Pharmacology, 371 46th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie, Mainz, GERMANY.
New york: Springer.
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2005 | Conference Abstract
Inhibition of the inter-action between CREB and its coactivator cbp by MEKK1 as revealed by fret
Oetjen, E.; Schlag, C.; Mayr, B. M.; Blume, R. & Knepel, W. (2005)
Naunyn-Schmiedeberg s Archives of Pharmacology, 371 46th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie, Mainz, GERMANY.
New york: Springer.
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2005 | Conference Abstract
Molecular mechanisms of insulin resistance
Gonzalez-Aguitre, M.; Boer, U. & Knepel, W. (2005)
Naunyn-Schmiedeberg s Archives of Pharmacology, 371 46th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie, Mainz, GERMANY.
New york: Springer.
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2005 | Journal Article
Protein kinase B activity is sufficient to mimic the effect of insulin on glucagon gene transcription
Schinner, S.; Barthel, A.; Dellas, C.; Grzeskowiak, R.; Sharma, S. K.; Oetjen, E. & Blume, R. et al. (2005)
Journal of Biological Chemistry, 280(8) pp. 7369-7376. DOI: https://doi.org/10.1074/jbc.M408560200
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2005 | Journal Article
The immunosuppressive drugs cyclosporin A and tacrolimus inhibit membrane depolarization-induced CREB transcriptional activity at the coactivator level
Oetjen, E.; Thoms, K. M.; Laufer, Y.; Pape, D.; Blume, R.; Li, P. F. & Knepel, W. (2005)
British Journal of Pharmacology, 144(7) pp. 982-993. DOI: https://doi.org/10.1038/sj.bjp.0706127
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2005 | Journal Article
Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans
Sharma, S. K.; Leinemann, U.; Ratke, R.; Oetjen, E.; Blume, R.; Dickel, C. & Knepel, W. (2005)
Biochemical Journal, 389 pp. 831-841. DOI: https://doi.org/10.1042/BJ20050334
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2006 | Conference Abstract
Effect of lithium on the CREB interacting cofactors CBP (CREB binding protein) and TORC (transducer of regulated creb)
Boer, U.; Krause, D. & Knepel, W. (2006)
Naunyn-Schmiedeberg s Archives of Pharmacology, 372 47th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie, Mainz, GERMANY.
New york: Springer.
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2006 | Conference Abstract
The immunosuppressive drug cyclosporine A induces apoptotic beta-cell death
Oetjen, E.; Plaumann, S.; Steinfelder, H. J. & Knepel, W. (2006)
Naunyn-Schmiedeberg s Archives of Pharmacology, 372 pp. 67-68. 47th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie, Mainz, GERMANY.
New york: Springer.
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2006 | Conference Abstract
Effect of hyperglycemia, hyperinsulinemia, oxidative stress and IL-1 beta on the insulin-iinduced inhibition of glucagon gene transcription
Gonzalez-Aguirre, M.; Boer, U. & Knepel, W. (2006)
Naunyn-Schmiedeberg s Archives of Pharmacology, 372 47th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie, Mainz, GERMANY.
New york: Springer.
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2006 | Conference Abstract
Role of the PAX6 homeodomain in regulation of glucagon gene transcrition
Grapp, M.; Kratzner, R.; Teichler, S. & Knepel, W. (2006)
Naunyn-Schmiedeberg s Archives of Pharmacology, 372 47th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie, Mainz, GERMANY.
New york: Springer.
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2006 | Journal Article |
Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line
Oetjen, E.; Lechleiter, A.; Blume, R.; Nihalani, D.; Holzman, L. & Knepel, W. (2006)
Diabetologia, 49(2) pp. 332-342. DOI: https://doi.org/10.1007/s00125-005-0087-1
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2007 | Conference Abstract
CREB dimerization is crucial for the interaction with TORC (transducer of regulated CREB)
Heinrich, A.; Boeer, U. & Knepel, W. (2007)
Naunyn-Schmiedeberg s Archives of Pharmacology, 375 48th Spring Meeting of the Deutsche-Gesellschaft-fur Experimentelle-ung-Klinische-Pharmakologie-und-Toxikologie, Mainz, GERMANY.
New york: Springer.
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2007 | Conference Abstract
Increase of interleukin-1beta-induced beta-cell apoptosis by the dual leucine zipper bearing kinase
Boerchers, S.; Blume, R.; Knepel, W. & Oetjen, E. (2007)
Experimental and Clinical Endocrinology & Diabetes, 115
Stuttgart: Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh.
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2007 | Conference Abstract
Identification of a GSK3 beta phosphorylation sites within the C-terminus of the transcriptional coactivator CBP
Matsiulka, A.; Oetjen, E. & Knepel, W. (2007)
Experimental and Clinical Endocrinology & Diabetes, 115
Stuttgart: Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh.
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2007 | Conference Abstract
Chronic insulin exposure with a decrease of insulin receptors results in diminished insulin sensitivity of glucagon gene transcription in pancreatic alpha cells
Gonzalez-Aguirre, M.; Boeer, U.; Oetjen, E. & Knepel, W. (2007)
Experimental and Clinical Endocrinology & Diabetes, 115
Stuttgart: Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh.
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2007 | Conference Abstract
The immunosuppressive drug cyclosporin A and the dual leucine zipper bearing kinase induce beta-cell apoptosis
Oetien, E.; Plaumann, S.; Boerchers, S.; Blume, R. & Knepel, W. (2007)
Experimental and Clinical Endocrinology & Diabetes, 115
Stuttgart: Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh.
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2007 | Conference Abstract
Inhibition of MafA transcriptional activity contributes to the inhibition of human insulin gene transcription by MEKK1 and interleukin-1beta
Oetjen, E.; Blume, R.; Cierny, I.; Kutschenko, A.; Kraetzner, R.; Stein, R. & Knepel, W. (2007)
Naunyn-Schmiedeberg s Archives of Pharmacology, 375 48th Spring Meeting of the Deutsche-Gesellschaft-fur Experimentelle-ung-Klinische-Pharmakologie-und-Toxikologie, Mainz, GERMANY.
New york: Springer.
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2007 | Conference Abstract
Effects of the antidepressant citalopram on CRE/CREB-directed gene transcription in transgenic reporter gene mice
Noll, C.; Boeer, U.; Cierny, I. & Knepel, W. (2007)
Naunyn-Schmiedeberg s Archives of Pharmacology, 375 48th Spring Meeting of the Deutsche-Gesellschaft-fur Experimentelle-ung-Klinische-Pharmakologie-und-Toxikologie, Mainz, GERMANY.
New york: Springer.
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2007 | Journal Article
Enhancement by lithium of CAMP-induced CRE/CREB-directed gene transcription conferred by TORC on the CREB basic leucine zipper domain
Boer, U.; Eglins, J.; Krause, D.; Schnell, S.; Schofl, C. & Knepel, W. (2007)
Biochemical Journal, 408 pp. 69-77. DOI: https://doi.org/10.1042/BJ20070796
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2007 | Journal Article |
CRE/CREB-Driven Up-Regulation of Gene Expression by Chronic Social Stress in CRE-Luciferase Transgenic Mice: Reversal by Antidepressant Treatment
Boeer, U.; Alejel, T.; Beimesche, S.; Cierny, I.; Krause, D.; Knepel, W. & Fluegge, G. (2007)
PLoS ONE, 2(5) art. e431. DOI: https://doi.org/10.1371/journal.pone.0000431
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2007 | Journal Article |
Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1 beta and mitogen-activated protein kinase kinase kinase in pancreatic islet beta cells
Oetjen, E.; Blume, R.; Cierny, I.; Schlag, C.; Kutschenko, A.; Kraetzner, R. & Stein, R. et al. (2007)
Diabetologia, 50(8) pp. 1678-1687. DOI: https://doi.org/10.1007/s00125-007-0712-2
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2008 | Conference Abstract
Facilitation of the protein-protein interaction between CREB and its co-activator TORC (transducer of regulated CREB) by lithium
Heinrich, A.; Boeer, U.; Tzvetkov, M. V. & Knepel, W. (2008)
Naunyn-Schmiedeberg s Archives of Pharmacology, 377 49th Annual Meeting German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology, Mainz, GERMANY.
New york: Springer.
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2008 | Journal Article
Synthesis of formacetal-linked dinucleotides to facilitate dsDNA bending and binding to the homeodomain of Pax6
Pitulescu, M.; Grapp, M.; Kraetzner, R.; Knepel, W. & Diederichsen, U. (2008)
European Journal of Organic Chemistry,(12) pp. 2100-2106. DOI: https://doi.org/10.1002/ejoc.200701178
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2008 | Journal Article
Activation of the dual-leucine-zipper-bearing kinase and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin A
Plaumann, S.; Blume, R.; Boerchers, S.; Steinfelder, H. J.; Knepel, W. & Oetjen, E. (2008)
Molecular Pharmacology, 73(3) pp. 652-659. DOI: https://doi.org/10.1124/mol.107.040782
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2008 | Journal Article |
Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice
Boeer, U.; Cierny, I.; Krause, D.; Heinrich, A.; Lin, H.; Mayr, G. & Hiemke, C. et al. (2008)
Neuropsychopharmacology, 33(10) pp. 2407-2415. DOI: https://doi.org/10.1038/sj.npp.1301640
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2008 | Journal Article |
Loss of insulin-induced inhibition of glucagon gene transcription in hamster pancreatic islet alpha cells by long-term insulin exposure
Gonzalez, M.; Boeer, U.; Dickel, C.; Quentin, T.; Cierny, I.; Oetjen, E. & Knepel, W. (2008)
Diabetologia, 51(11) pp. 2012-2021. DOI: https://doi.org/10.1007/s00125-008-1134-5
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2008 | Journal Article
A peroxisome proliferator-activated receptor gamma-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription
Kraetzner, R.; Froehlich, F.; Lepler, K.; Schroeder, M.; Roeher, K.; Dickel, C. & Tzvetkov, M. V. et al. (2008)
Molecular Pharmacology, 73(2) pp. 509-517. DOI: https://doi.org/10.1124/mol.107.035568
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2009 | Conference Abstract
The lithium-induced increase of the interaction between CREB and its coactivator TORC1 is not dependent on lysine 290 of CREB
Heinrich, A. H.; Boeer, U.; Oetjen, E. & Knepel, W. (2009)
Naunyn-Schmiedeberg s Archives of Pharmacology, 379 50th Annual Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie, Mainz, GERMANY.
New york: Springer.
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2009 | Journal Article |
Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator TORC
Heinrich, A.; Boeer, U.; Tzvetkov, M.; Oetjen, E. & Knepel, W. (2009)
Bioscience Reports, 29(2) pp. 77-87. DOI: https://doi.org/10.1042/BSR20080116
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2009 | Journal Article
The homeodomain of PAX6 is essential for PAX6-dependent activation of the rat glucagon gene promoter: Evidence for a PH0-like binding that induces an active conformation
Grapp, M.; Teichler, S.; Kitz, J. ; Dibaj, P.; Dickel, C.; Knepel, W. & Kraetzner, R. (2009)
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1789(5) pp. 403-412. DOI: https://doi.org/10.1016/j.bbagrm.2009.02.001
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2010 | Journal Article
A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: Reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice
Boeer, U.; Noll, C. ; Cierny, I.; Krause, D.; Hiemke, C. & Knepel, W. (2010)
European Journal of Pharmacology, 633(1-3) pp. 33-38. DOI: https://doi.org/10.1016/j.ejphar.2010.01.016
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